Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Christina A. Mitchell"'
Autor:
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse mode
Externí odkaz:
https://doaj.org/article/226bfb45e8934ee1ba253ad4552b6197
Autor:
Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individu
Externí odkaz:
https://doaj.org/article/b82edde0750c4c3ea2517f10c34927f4
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endoso
Externí odkaz:
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characteri
Externí odkaz:
https://doaj.org/article/829dfbdf5cfe459dbb5485f5449b9504
Autor:
Sarah E. Conduit, Elizabeth M. Davies, Alex J. Fulcher, Viola Oorschot, Christina A. Mitchell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment o
Externí odkaz:
https://doaj.org/article/fb8468d7a7d848198f306db1e3a4ec54
Autor:
Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson, Roger J. Daly
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator o
Externí odkaz:
https://doaj.org/article/16b94020768b4b0886330aa70dd0da0d
Autor:
Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina A. Mitchell, Meagan J. McGrath
Publikováno v:
Autophagy. :1-18
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy function, a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bfd050106eeb659a90ed23db3ca28a
https://doi.org/10.1080/15548627.2022.2128019
https://doi.org/10.1080/15548627.2022.2128019
Autor:
Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2905-2922.e5 (2019)
Summary: The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP) att
Externí odkaz:
https://doaj.org/article/60e76c7095e44457a9a4422b890fabd6
Autor:
Elizabeth M. Davies, Rajendra Gurung, Kai Qin Le, Katherine T. T. Roan, Richard P. Harvey, Geraldine M. Mitchell, Quenten Schwarz, Christina A. Mitchell
Publikováno v:
Science Advances. 9
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P 2 to PI(3,4,5)P 3 , activating AKT; however, PI3K/AKT do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4ba1a101bfabcab36ceed205fad802
https://doi.org/10.1126/sciadv.add6911
https://doi.org/10.1126/sciadv.add6911