Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Christina A Mitchell"'
Autor:
Sandra J Feeney, Meagan J McGrath, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Colleen E D'Arcy, John T Price, Catriona A McLean, Rossella Tupler, Christina A Mitchell
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117665 (2015)
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease with no effective treatment. The genetic cause of FSHD is complex and the primary pathogenic insult underlying the muscle disease is unknown. Several disease candidate gen
Externí odkaz:
https://doaj.org/article/07bab8db7cf243d98f24598e7f2f1235
Autor:
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse mode
Externí odkaz:
https://doaj.org/article/226bfb45e8934ee1ba253ad4552b6197
Autor:
Shehnaaz S M Manji, Louise H Williams, Kerry A Miller, Lisa M Ooms, Melanie Bahlo, Christina A Mitchell, Hans-Henrik M Dahl
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17607 (2011)
Hearing impairment is the most common sensory impairment in humans, affecting 1:1,000 births. We have identified an ENU generated mouse mutant, Mozart, with recessively inherited, non-syndromic progressive hearing loss caused by a mutation in the syn
Externí odkaz:
https://doaj.org/article/66b3bb9bee1a448193c836fec6c9afef
Autor:
Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individu
Externí odkaz:
https://doaj.org/article/b82edde0750c4c3ea2517f10c34927f4
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characteri
Externí odkaz:
https://doaj.org/article/829dfbdf5cfe459dbb5485f5449b9504
Autor:
Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina A. Mitchell, Meagan J. McGrath
Publikováno v:
Autophagy. :1-18
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy function, a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bfd050106eeb659a90ed23db3ca28a
https://doi.org/10.1080/15548627.2022.2128019
https://doi.org/10.1080/15548627.2022.2128019
Autor:
Elizabeth M. Davies, Rajendra Gurung, Kai Qin Le, Katherine T. T. Roan, Richard P. Harvey, Geraldine M. Mitchell, Quenten Schwarz, Christina A. Mitchell
Publikováno v:
Science Advances. 9
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P 2 to PI(3,4,5)P 3 , activating AKT; however, PI3K/AKT do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4ba1a101bfabcab36ceed205fad802
https://doi.org/10.1126/sciadv.add6911
https://doi.org/10.1126/sciadv.add6911
Autor:
Maria Lambouras, Charlotte Roelofs, Melrine Pereira, Emily Gruber, Jessica L. Vieusseux, Patrick Lanteri, Cameron N. Johnstone, Fenella Muntz, Sandra O’Toole, Lisa M. Ooms, Christina A. Mitchell, Robin L. Anderson, Kara L. Britt
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5666
Estrogen receptor-positive breast cancers (ER+ BCas) are the most common form of BCa and are increasing in incidence, largely due to changes in reproductive practices in recent decades. Tamoxifen is prescribed as a component of standard-of-care endoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0824c79834eea55eedd82df1d633fd33
Publikováno v:
Autophagy. 19:1365-1367
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e533a5fcbd221f6b1a752265e01a2f2f
https://doi.org/10.1080/15548627.2022.2124499
https://doi.org/10.1080/15548627.2022.2124499
Publikováno v:
Cancers. 15(1)
The majority of breast cancers are estrogen receptor-positive (ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9127ab681a723193e66d17b66571122
https://pubmed.ncbi.nlm.nih.gov/36612130
https://pubmed.ncbi.nlm.nih.gov/36612130