Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christina A Higgins"'
Autor:
Georgios Voloudakis, James M. Vicari, Sanan Venkatesh, Gabriel E. Hoffman, Kristina Dobrindt, Wen Zhang, Noam D. Beckmann, Christina A. Higgins, Stathis Argyriou, Shan Jiang, Daisy Hoagland, Lina Gao, André Corvelo, Kelly Cho, Kyung Min Lee, Jiantao Bian, Jennifer S. Lee, Sudha K. Iyengar, Shiuh-Wen Luoh, Schahram Akbarian, Robert Striker, Themistocles L. Assimes, Eric E. Schadt, Julie A. Lynch, Miriam Merad, Benjamin R. tenOever, Alexander W. Charney, Mount Sinai COVID-19 Biobank, VA Million Veteran Program COVID-19 Science Initiative, Kristen J. Brennand, John F. Fullard, Panos Roussos
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes that reduce COVID-19 host suscepti
Externí odkaz:
https://doaj.org/article/5a0dec67bb0f4272bc09c17317ff23c0
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Boris Bonaventure, Andrew P. Kurland, Chengjin Ye, Tomer M. Yaron, Jared L. Johnson, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martínez-Sobrido, Benjamin tenOever, Jeffrey R. Johnson
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, drastically modifies infected cells to optimize virus replication. One such modification is the activation
Externí odkaz:
https://doaj.org/article/f4d8484e81a64893a39af20ce68f7785
Autor:
Katherine A. Amato, Luis A. Haddock, Katarina M. Braun, Victoria Meliopoulos, Brandi Livingston, Rebekah Honce, Grace A. Schaack, Emma Boehm, Christina A. Higgins, Gabrielle L. Barry, Katia Koelle, Stacey Schultz-Cherry, Thomas C. Friedrich, Andrew Mehle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track vir
Externí odkaz:
https://doaj.org/article/d3cb8e6727e14346a2d7c30f2568dc31
Autor:
Gloria P. Larson, Vy Tran, Shuǐqìng Yú, Yíngyún Caì, Christina A. Higgins, Danielle M. Smith, Steven F. Baker, Sheli R. Radoshitzky, Jens H. Kuhn, Andrew Mehle
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2175-2183.e4 (2019)
Summary: All viruses balance interactions between cellular machinery co-opted to support replication and host factors deployed to halt the infection. We use gene correlation analysis to perform an unbiased screen for host factors involved in influenz
Externí odkaz:
https://doaj.org/article/c1bec00affbc4b76bbe599ad26f94b56
Autor:
Yuling Han, Jiajun Zhu, Liuliu Yang, Benjamin E. Nilsson-Payant, Romulo Hurtado, Lauretta A. Lacko, Xiaolu Sun, Aravind R. Gade, Christina A. Higgins, Whitney J. Sisso, Xue Dong, Maple Wang, Zhengming Chen, David D. Ho, Geoffrey S. Pitt, Robert E. Schwartz, Benjamin R. tenOever, Todd Evans, Shuibing Chen
Publikováno v:
Circulation Research. 130:963-977
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia. However, it is challenging to explore human sinoatrial node (SAN) path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca5c3a94c5352599b674986afbdd73c
https://doi.org/10.1161/circresaha.121.320518
https://doi.org/10.1161/circresaha.121.320518
Autor:
Mitchell P. Ledwith, Vy Tran, Thiprampai Thamamongood, Christina A. Higgins, Shashank Tripathi, Max W. Chang, Christopher Benner, Adolfo García-Sastre, Martin Schwemmle, Adrianus C. M. Boon, Michael S. Diamond, Andrew Mehle
Publikováno v:
Proceedings, Vol 50, Iss 1, p 134 (2020)
Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state. Interferon stimulation or pathogen challenge robustl
Externí odkaz:
https://doaj.org/article/1682a874e2d44853a040dd199fbb069a
Autor:
Gabrielle L. Barry, Luis A. Haddock, Brandi Livingston, Andrew Mehle, Katarina M. Braun, Victoria A. Meliopoulos, Katherine A. Amato, Grace A. Schaack, Emma C. Boehm, Katia Koelle, Stacey Schultz-Cherry, Thomas C. Friedrich, Rebekah Honce, Christina A. Higgins
Publikováno v:
Nature Communications. 13
Transmission of influenza A viruses (IAV) between hosts is subject to numerous physical and biological barriers that impose genetic bottlenecks, constraining viral diversity and adaptation. The presence of bottlenecks within individual hosts and thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c01e3e1b7d3d35a77f16de3904d2a1a
https://doi.org/10.1038/s41467-022-31147-0
https://doi.org/10.1038/s41467-022-31147-0
Autor:
Joshua A. Acklin, Maryline Panis, Christina A Higgins, Skyler Uhl, Yaron Bram, Daniel Blanco-Melo, Benjamin R. tenOever, Benjamin E. Nilsson-Payant, Robert E. Schwartz, Ashley S. Doane, Vasuretha Chandar, Rohit Chandwani, Phillip Cohen, Brad R. Rosenberg, Adrien Grimont, Roosheel S. Patel, Olivier Elemento, Jean K. Lim
Publikováno v:
Journal of Virology
SARS-CoV-2, the etiological agent of COVID-19, is characterized by a delay in type I interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production. Here, we investigate the underlying molecular basis for this imbalance and impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a590a5030650165d61fc1a95ca0cc2
https://pubmed.ncbi.nlm.nih.gov/34523966
https://pubmed.ncbi.nlm.nih.gov/34523966
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Andrew P. Kurland, Chengjin Ye, Tomer Yaron, Jared L. Johnson, Boris Bonaventure, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martinez-Sobrido, Benjamin R. tenOever, Jeffrey R. Johnson
SARS-CoV-2, the causative agent of the COVID-19 pandemic, drastically modifies infected cells in an effort to optimize virus replication. Included is the activation of the host p38 mitogen-activated protein kinase (MAPK) pathway, which plays a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf25b756c76ccfd4b75371b1616865cb
https://doi.org/10.1101/2021.08.20.457146
https://doi.org/10.1101/2021.08.20.457146
Autor:
Martin Schwemmle, Thiprampai Thamamongood, Christina A. Higgins, Christopher Benner, Shashank Tripathi, Michael S. Diamond, Mitchell P. Ledwith, Max W. Chang, Vy Tran, Adrianus C. M. Boon, Andrew Mehle, Adolfo García-Sastre
Publikováno v:
Proceedings, Vol 50, Iss 134, p 134 (2020)
Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state. Interferon stimulation or pathogen challenge robustl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1194d7e575101d74918293468bd0fe82
https://www.mdpi.com/2504-3900/50/1/134
https://www.mdpi.com/2504-3900/50/1/134