Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Christina A Castellani"'
Autor:
Phyo W. Win, Julia Nyugen, Amanda L. Morin, Charles E. Newcomb, Shiva M. Singh, Noha Gomaa, Christina A. Castellani
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Objective Mitochondrial dysfunction and nuclear epigenetic alterations, two hallmarks of aging, are associated with aberrant development and complex disease risk. Here, we report a method for the simultaneous assessment of mitochondrial DNA
Externí odkaz:
https://doaj.org/article/7e75765013594295828e5a9c26434cac
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Chronic diabetic complications affect multiple organs causing widespread organ damage. Although there are some commonalities, the phenotype of such changes show tissue specific variation. Given this, we examined whether differences in circul
Externí odkaz:
https://doaj.org/article/e4622ebf46fb42999bd8448b0e968deb
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome and con
Externí odkaz:
https://doaj.org/article/60b77cf19133468381293112cab48c87
Autor:
Christina A. Castellani, Ryan J. Longchamps, Jason A. Sumpter, Charles E. Newcomb, John A. Lane, Megan L. Grove, Jan Bressler, Jennifer A. Brody, James S. Floyd, Traci M. Bartz, Kent D. Taylor, Penglong Wang, Adrienne Tin, Josef Coresh, James S. Pankow, Myriam Fornage, Eliseo Guallar, Brian O’Rourke, Nathan Pankratz, Chunyu Liu, Daniel Levy, Nona Sotoodehnia, Eric Boerwinkle, Dan E. Arking
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Background Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by which mtDNA-CN influences disease is not currently understood. One suc
Externí odkaz:
https://doaj.org/article/0d14c8d7fa654cee80423f94c579a922
Autor:
Di Zhao, Traci M. Bartz, Nona Sotoodehnia, Wendy S. Post, Susan R. Heckbert, Alvaro Alonso, Ryan J. Longchamps, Christina A. Castellani, Yun Soo Hong, Jerome I. Rotter, Henry J. Lin, Brian O’Rourke, Nathan Pankratz, John A. Lane, Stephanie Y. Yang, Eliseo Guallar, Dan E. Arking
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background Mechanistic studies suggest that mitochondria DNA (mtDNA) dysfunction may be associated with increased risk of atrial fibrillation (AF). The association between mtDNA copy number (mtDNA-CN) and incident AF in the general populatio
Externí odkaz:
https://doaj.org/article/252c2d273dba4941b72da4413ca8d99a
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Fetal alcohol spectrum disorders (FASD) are common, seen in 1–5% of the population in the USA and Canada. Children diagnosed with FASD are not likely to remain with their biological parents, facing early maternal separation and
Externí odkaz:
https://doaj.org/article/4bf0ae8257d44c68ba53ee239588b1fa
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
The search for what causes schizophrenia has been onerous. This research has included extensive assessment of a variety of genetic and environmental factors using ever emerging high-resolution technologies and traditional understanding of the biology
Externí odkaz:
https://doaj.org/article/d67d58aa00aa42c591a9c4935dd066e4
Autor:
Ryan J Longchamps, Christina A Castellani, Stephanie Y Yang, Charles E Newcomb, Jason A Sumpter, John Lane, Megan L Grove, Eliseo Guallar, Nathan Pankratz, Kent D Taylor, Jerome I Rotter, Eric Boerwinkle, Dan E Arking
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228166 (2020)
Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell, is a minimally invasive proxy measure for mitochondrial function and has been associated with several aging-related diseases. Although quantitative r
Externí odkaz:
https://doaj.org/article/cb9b6ad000f4447981ff3b7c5166580f
Autor:
Penglong Wang, Kent D. Taylor, Xianbang Sun, Xiuqing Guo, Jie Yao, JoAnn E. Manson, Jeffrey Haessler, Yongmei Liu, Alexander P. Reiner, Daniel Levy, Eric Boerwinkle, Jennifer A. Smith, David Van Den Berg, Dan E. Arking, Tuuli Lappalainen, Jan Bressler, Lifang Hou, Christina A. Castellani, Stephen S. Rich, Wei Zhao, Tianxiao Huan, Silva Kasela, Megan L. Grove, Chunyu Liu, Patricia A. Peyser, Jerome I. Rotter, Lawrence F. Bielak, Joehanes Roby, Charles Kooperberg, Myriam Fornage, Ryan J. Longchamps
Publikováno v:
Hum Mol Genet
We conducted cohort- and race-specific epigenome-wide association analyses of mitochondrial deoxyribonucleic acid (mtDNA) copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five cohorts (n = 6182, mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114263bbc14adc19536a3453c0ee3b6c
https://doi.org/10.1093/hmg/ddab240
https://doi.org/10.1093/hmg/ddab240
Publikováno v:
Physiological genomics. 54(8)
Skeletal muscle is adaptable to a direct stimulus of exercise-induced muscle damage (EIMD). Local muscle gene networks and systemic circulatory factors respond to EIMD within days, mediating anti-inflammation and cellular proliferation. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac22c2de36f51ff6b781c0fec9658e1
https://pubmed.ncbi.nlm.nih.gov/35723223
https://pubmed.ncbi.nlm.nih.gov/35723223