Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Christina, Meyer"'
Autor:
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,
Externí odkaz:
https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus there is a need to
Externí odkaz:
https://doaj.org/article/80bd9bddf2c642c8ae1500f79d473c8a
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Nyzil Massey, Suraj Sundara Vasanthi, Manikandan Samidurai, Meghan Gage, Nikhil Rao, Christina Meyer, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Organophosphate nerve agent (OPNA) exposure induces acute and long-term neurological deficits. OPNA exposure at sub-lethal concentrations induces irreversible inhibition of acetylcholinesterase and cholinergic toxidrome and develops status epilepticu
Externí odkaz:
https://doaj.org/article/5bcec7d195a74a1fbab94e68ca61bb2b
Autor:
Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2061 (2023)
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc
Externí odkaz:
https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24
This book brings together an international group of scholars who chart and analyze the ways in which comic book history and new forms of graphic narrative have negotiated the aesthetic, social, political, economic, and cultural interactions that reac
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-6 (2021)
Abstract Background Capnocytophaga canimorsus (C. canimorsus) infections are rare and usually present with unspecific symptoms, which can eventually end in fatal septic shock and multiorgan failure. The severe acute respiratory syndrome coronavirus 2
Externí odkaz:
https://doaj.org/article/96b4fc1b5c304780878c8dc71fd2f759
Autor:
Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal
Externí odkaz:
https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b
Autor:
Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n
Externí odkaz:
https://doaj.org/article/631974d04d3d4aefa5b682931e544a3c
Autor:
Afsaneh Shirani, Scott R Dalton, Eric J Avery, Lakshman Arcot Jayagopal, Christina Meyer, Olaf Stuve, Rana Zabad
Publikováno v:
Journal of Central Nervous System Disease, Vol 13 (2021)
A 48-year-old Caucasian woman with history of multiple sclerosis (MS) presented with erythematous papulonodular lesions in her extremities and trunk. She was being treated with glatiramer acetate (GA) for the past 10 years and the glatiramoid, Glatop
Externí odkaz:
https://doaj.org/article/d3fdd3766ec346f58a66ac08837762f7