Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christina, Kyrousi"'
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Autor:
Christina Kyrousi, Adam C. O’Neill, Agnieska Brazovskaja, Zhisong He, Pavel Kielkowski, Laure Coquand, Rossella Di Giaimo, Pierpaolo D’ Andrea, Alexander Belka, Andrea Forero Echeverry, Davide Mei, Matteo Lenge, Cristiana Cruceanu, Isabel Y. Buchsbaum, Shahryar Khattak, Guimiot Fabien, Elisabeth Binder, Frances Elmslie, Renzo Guerrini, Alexandre D. Baffet, Stephan A. Sieber, Barbara Treutlein, Stephen P. Robertson, Silvia Cappello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neu
Externí odkaz:
https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e981
Autor:
Ioannis Angelopoulos, Georgios Gakis, Kyriakos Birmpas, Christina Kyrousi, Evagelia Eva Habeos, Konstantina Kaplani, Zoi Lygerou, Ioannis Habeos, Stavros Taraviras
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The neural stem cell niche is a key regulator participating in the maintenance, regeneration, and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons throughout life, which is important for tissue homeostasis and brain
Externí odkaz:
https://doaj.org/article/8d9eb356380a4ced89c95de4a789f3e0
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurodevelopmental disorders (NDDs) are a heterogeneous group of impairments that affect the development of the central nervous system leading to abnormal brain function. NDDs affect a great percentage of the population worldwide, imposing a high soc
Externí odkaz:
https://doaj.org/article/3c1025a2e7384b608da341e06efa5a50
Autor:
Francesco Di Matteo, Fabrizia Pipicelli, Christina Kyrousi, Isabella Tovecci, Eduardo Penna, Marianna Crispino, Angela Chambery, Rosita Russo, Ane Cristina Ayo‐Martin, Martina Giordano, Anke Hoffmann, Emilio Ciusani, Laura Canafoglia, Magdalena Götz, Rossella Di Giaimo, Silvia Cappello
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-21 (2020)
Abstract Progressive myoclonus epilepsy (PME) of Unverricht–Lundborg type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide. Mutations in the gene encoding cystatin B (CSTB) are the primary gene
Externí odkaz:
https://doaj.org/article/d7924a20df5e4060b7e35a5b2deeec27
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Cortical development is a very complex process in which any temporal or spatial alterations can give rise to a wide range of cortical malformations. Among those malformations, periventricular heterotopia (PH) is characterized by clusters of neurons t
Externí odkaz:
https://doaj.org/article/58df76782da24486b88ee31ad59ccbd3
Autor:
Adam C. O’Neill, Christina Kyrousi, Johannes Klaus, Richard J. Leventer, Edwin P. Kirk, Andrew Fry, Daniela T. Pilz, Tim Morgan, Zandra A. Jenkins, Micha Drukker, Samuel F. Berkovic, Ingrid E. Scheffer, Renzo Guerrini, David M. Markie, Magdalena Götz, Silvia Cappello, Stephen P. Robertson
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2729-2741.e6 (2018)
Summary: The mammalian neocortex has undergone remarkable changes through evolution. A consequence of such rapid evolutionary events could be a trade-off that has rendered the brain susceptible to certain neurodevelopmental and neuropsychiatric condi
Externí odkaz:
https://doaj.org/article/d95a7e66dd6f4400b94ec2e97ad2e7b3
Autor:
Adam C. O’Neill, Christina Kyrousi, Melanie Einsiedler, Ingo Burtscher, Micha Drukker, David M. Markie, Edwin P. Kirk, Magdalena Götz, Stephen P. Robertson, Silvia Cappello
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Disorders of neuronal mispositioning during brain development are phenotypically heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic variants in a Hippo signaling factor—MOB2—in a patient with one such disorde
Externí odkaz:
https://doaj.org/article/55a80b0d7f3942dc8de72836ea5c1499
Autor:
Anthi C. Krontira, Cristiana Cruceanu, Christina Kyrousi, Leander Dony, Marie-Helen Link, Nils Kappelmann, Dorothee Pöhlchen, Simone Roeh, Vincenza Sportelli, Barbara Wölfel, Maik Ködel, Susann Sauer, null Monika-Rex-Haffner, Marta Labeur, Silvia Cappello, Elisabeth B. Binder
SummaryGlucocorticoids are important for proper organ maturation1. Increased exposure to these hormones during pregnancy, as a result of commonly prescribed synthetic glucocorticoids such as dexamethasone in preterm births2, has been associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a200dbc0a228c40772d20ee982e23c
https://doi.org/10.1101/2022.08.21.504700
https://doi.org/10.1101/2022.08.21.504700
Autor:
Fabrizia Pipicelli, Natalia Baumann, Rossella Di Giaimo, Christina Kyrousi, Rebecca Bonrath, Denis Jabaudon, Silvia Cappello
The imbalance between excitatory and inhibitory neurons in the human brain might lead to neurodevelopmental and neuropsychiatric disorders including cortical malformations, epilepsy, and autism spectrum disorders. We propose that the extracellular en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b486e1d747a569b4fbda2364afd4d2c0
https://doi.org/10.1101/2022.05.03.490384
https://doi.org/10.1101/2022.05.03.490384
Autor:
Stefanie Wehner, Nathalie Gerstner, Christina Kyrousi, Silvia Martinelli, Silvia Cappello, Rossella Di Giaimo, Cristiana Cruceanu, Anthi C. Krontira, David S. Fischer, Maik Koedel, Janine Arloth, Vincenza Sportelli, Monika Rex-Haffner, Michael S. Breen, Darina Czamara, Leander Dony, Elisabeth B. Binder, Fabian J. Theis, Simone Roeh, Susann Sauer, Lea Kaspar
Publikováno v:
Am. J. Psychiatry 179, 375-387 (2021)
OBJECTIVE: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c8262351e5edf16042d50f87cf3b41
https://pubmed.ncbi.nlm.nih.gov/34698522
https://pubmed.ncbi.nlm.nih.gov/34698522