Výsledky vyhledávání - "Christina, Heinlein"

Akademický článek

Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.

Autor: Florian Wegwitz, Mark-Andreas Kluth, Claudia Mänz, Benjamin Otto, Katharina Gruner, Christina Heinlein, Marion Kühl, Gabriele Warnecke, Udo Schumacher, Wolfgang Deppert, Genrich V Tolstonog

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12103 (2010)

BACKGROUND: In analogy to normal stem cell differentiation, the current cancer stem cell (CSC) model presumes a hierarchical organization and an irreversible differentiation in tumor tissue. Accordingly, CSCs should comprise only a small subset of th

Externí odkaz: https://doaj.org/article/4492c63244e942aea18035dc8d6b04f2

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CEBPfactors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis

Autor: Cagatay Günes, Uwe Knippschild, Frauke Krepulat, Julia M. Weise, Karl-Lenhard Rudolph, Christina Heinlein, Florian Kuchenbauer, Mukesh Kumar, Jitendra K. Meena, Sebastian Iben, Britta Witt, Sylvia Koch, Wolfgang Deppert

Publikováno v: International Journal of Cancer. 132:2032-2043

Telomerase is activated in the majority of invasive breast cancers, but the time point of telomerase activation during mammary carcinogenesis is not clear. We have recently presented a transgenic mouse model to study human telomerase reverse transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf077d8822e3e2f1fd6ab03f7dae4dc
https://doi.org/10.1002/ijc.27880

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A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry

Autor: Wolfgang Deppert, Christina Heinlein, Antony W. Braithwaite, Daniel Speidel

Publikováno v: Cell Cycle. 9:3584-3590

Cell cycle alterations are fundamental to many physiological processes but their detection has proven difficult when cells are in the context of a tissue structure. Here we describe an easy, rapid and optimization-free procedure for obtaining high re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afb338b3629f90aa91f6a39db34dcaf
https://doi.org/10.4161/cc.9.17.12831

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Detection of different tumor growth kinetics in single transgenic mice with oncogene-induced mammary carcinomas by flat-panel volume computed tomography

Autor: Florian Wegwitz, Christina Heinlein, Frauke Krepulat, Christian Dullin, Katharina Jannasch, Wolfgang Deppert, Frauke Alves

Publikováno v: International Journal of Cancer. 125:62-70

Transgenic mouse models offer an excellent opportunity for studying the molecular basis of cancer development and progression. Here we applied flat-panel volume computed tomography (fpVCT) to monitor tumor progression as well as the development of tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1372e635463d4dc0577cf40f035abf9
https://doi.org/10.1002/ijc.24332

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Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice

Autor: Eva, Lenfert, Claudia, Maenz, Christina, Heinlein, Katharina, Jannasch, Udo, Schumacher, Klaus, Pantel, Genrich V, Tolstonog, Wolfgang, Deppert, Florian, Wegwitz

Publikováno v: International journal of cancer. 136(6)

To study the postulated mutant p53 (mutp53) "gain of function" effects in mammary tumor development, progression and metastasis, we crossed SV40 transgenic WAP-T mice with mutant p53 transgenic WAP-mutp53 mice. Compared to tumors in monotransgenic WA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f4172a846d3acc86e67c21a38616b01
https://pubmed.ncbi.nlm.nih.gov/25195563

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Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression

Autor: Udo Schumacher, Peter Nollau, Klaus Pantel, Genrich V. Tolstonog, José I. Martín-Subero, Florian Wegwitz, Christoph Wagener, Bauke Ylstra, Christina Heinlein, Wolfgang Deppert, Benjamin Otto, Reiner Siebert, Lars Oliver Baumbusch, Katharina Gruner, Thomas Streichert

Publikováno v: Otto, B, Gruner, K, Heinlein, C, Wegwitz, F, Nollau, P, Ylstra, B, Pantel, K, Schumacher, U, Baumbusch, L O, Martin-Subero, J I, Siebert, R, Wagener, C, Streichert, T, Deppert, W & Tolstonog, G V 2013, ' Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression ', International Journal of Cancer, vol. 132, no. 6, pp. 1300-1310 . https://doi.org/10.1002/ijc.27783
International Journal of Cancer, 132(6), 1300-1310. Wiley-Liss Inc.

Mammary carcinomas developing in SV40 transgenic WAP-T mice arise in two distinct histological phenotypes: as differentiated low-grade and undifferentiated high-grade tumors. We integrated different types of information such as histological grading,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38c6c697dcf7fd9109272b4f0735a04
https://research.vumc.nl/en/publications/30d43abf-f7c9-4209-afe6-0296011ac768

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High‐Resolution Cell Cycle and DNA Ploidy Analysis in Tissue Samples

Autor: Christina Heinlein, Daniel Speidel

Publikováno v: Current Protocols in Cytometry

This unit describes an easy, rapid, and universal procedure to process fresh and nitrogen-frozen tissue specimens for high-resolution cell cycle and DNA ploidy analysis. Unlike other protocols, this procedure does not require treating tissues with en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01468612d05fd776ba6e8e6fcda2ebe
https://doi.org/10.1002/0471142956.cy0739s56

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Analysis of the role of the actin cytoskeleton in the cell-to-cell transport of Tobacco mosaic virus (TMV) and of the secretory pathway in the targeting of the Grapevine fanleaf virus (GFLV) movement protein to plasmodesmata

Autor: Hofmann, Christina Heinlein, Manfred.

Thèse de doctorat : Biologie moléculaire : Strasbourg 1 : 2007.
Thèse soutenue sur un ensemble de travaux. Titre provenant de l'écran-titre. Bibliogr. f. 116-131.

Externí odkaz: http://eprints-scd-ulp.u-strasbg.fr:8080/00000847

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Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis

Autor: Wolfgang Deppert, Christina Heinlein, Frauke Krepulat, Daniel Speidel, Jiirgen Löhler, Genrich V. Tolstonog

Publikováno v: International journal of cancer. 122(8)

In human breast cancer, mutations in the p53 gene are associated with poor prognosis. However, analysis of patient data so far did not clarify, whether missense point mutations in the p53 gene, in addition to causing loss of wild-type p53 function, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67c6f4fe7690c0b41ae1ecdd12266ff
https://pubmed.ncbi.nlm.nih.gov/18092324

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