Nonlinear Z‐score modeling for improved detection of cognitive abnormality

Autor: John Kornak, Julie Fields, Walter Kremers, Sara Farmer, Hilary W. Heuer, Leah Forsberg, Danielle Brushaber, Amy Rindels, Hiroko Dodge, Sandra Weintraub, Lilah Besser, Brian Appleby, Yvette Bordelon, Jessica Bove, Patrick Brannelly, Christina Caso, Giovanni Coppola, Reilly Dever, Christina Dheel, Bradford Dickerson, Susan Dickinson, Sophia Dominguez, Kimiko Domoto‐Reilly, Kelley Faber, Jessica Ferrall, Ann Fishman, Jamie Fong, Tatiana Foroud, Ralitza Gavrilova, Deb Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff‐Radford, Neill Graff‐Radford, Ian M. Grant, Murray Grossman, Dana Haley, John Hsiao, Robin Hsiung, Edward D. Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, Daniel Kaufer, Diana Kerwin, David Knopman, Ruth Kraft, Joel Kramer, Walter Kukull, Maria Lapid, Irene Litvan, Peter Ljubenkov, Diane Lucente, Codrin Lungu, Ian Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott McGinnis, Emily McKinley, Mario Mendez, Bruce Miller, Namita Multani, Chiadi Onyike, Jaya Padmanabhan, Alexander Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Erik D. Roberson, Emily Rogalski‐Miller, Pheth Sengdy, Les Shaw, Adam M. Staffaroni, Margaret Sutherland, Jeremy Syrjanen, Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Ping Wang, Bonnie Wong, Zbigniew Wszolek, Brad Boeve, Adam Boxer, Howard Rosen, ARTFL/LEFFTDS Consortium

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 797-808 (2019)

Abstract Introduction Conventional Z‐scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these “adjusted” Z‐scores better represent whe

Externí odkaz: https://doaj.org/article/a6622d356e19452690bcb069ec439d27

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease

Autor: Caitlin S. Latimer, Kiel Shuey, Carole L. Smith, Chloe G Cross, Bryce L. Sopher, Michael O. Dorschner, Stephanie A. Bucks, Thomas J. Grabowski, Suman Jayadev, Debby W. Tsuang, Kimiko Domoto-Reilly, Kristoffer Rhoads, Michael Lardelli, Thomas D. Bird, Chizuru Kinoshita, Paul N. Valdmanis, Meredith M. Course, Christopher Dirk Keene, Jessica E. Young, Luis F. Gonzalez-Cuyar, Leah Osnis, Gwenn A. Garden, Kathryn P Scherpelz, Morgan Newman, James B. Leverenz, Jacquelyn E. Braggin, Ellen M. Wijsman, Seyyed H. M. Nik, Richard S. Morrison, Christina Caso

Publikováno v: Annals of Clinical and Translational Neurology

Objective Autosomal‐dominant familial Alzheimer disease (AD) is caused by by variants in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP). Previously, we reported a rare PSEN2 frameshift variant in an early‐onset AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d3f149cc53a10b4c150aed4d43ce92
https://doi.org/10.1002/acn3.755

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort

Autor: Jessica Ferrall, Julie A. Fields, Edward D. Huey, Anna Karydas, Len Petrucelli, John Kornak, Kejal Kantarci, Pei Ning Wang, G-Y Hsiung, Dana Haley, Artfl, Emily C. McKinley, Erik D. Roberson, Masood Manoochehri, Maria Carmela Tartaglia, Brian S. Appleby, Zbigniew Wszolek, Walter K. Kremers, Amy Wolf, Diana R. Kerwin, Bradford C. Dickerson, Murray Grossman, Bruce L. Miller, Ian Grant, Ann Fishman, Jill Goldman, Leah K. Forsberg, Miranda Maldonado, Howard J. Rosen, Ian R. Mackenzie, Patrick Brannelly, Joel H. Kramer, Eliana Marisa Ramos, Behnaz Ghazanfari, Lefftds consortia, Katherine P. Rankin, Katya Rascovsky, Mario F. Mendez, Yvette Bordelon, Leslie M. Shaw, Arthur W. Toga, Chiadikaobi U. Onyike, Irene Litvan, Scott M. McGinnis, Peter A. Ljubenkov, Hilary W. Heuer, Rodney Pearlman, Walter A. Kukull, Nadine Tatton, Adam L. Boxer, Ruth Kraft, David T.W. Jones, Joanne Taylor, Giovanni Coppola, Tatiana Foroud, Debra Gearhart, Jonathan Graff-Radford, B. F. Boeve, Alexander Pantelyat, Danielle Brushaber, Daniel I. Kaufer, Rosa Rademakers, Madeline Potter, Kelly Faber, John Q. Trojanowski, Jamie Fong, Christina Caso, Emily Rogalski, Nupur Ghoshal, Neill Graff-Radford, Jeremy Syrjanen, Susan Dickinson, Pheth Sengdy, Jessica Bove, Sandra Weintraub, Bonnie Wong, Kimiko Domoto-Reilly, David S. Knopman, David J. Irwin

Publikováno v: Alzheimers Dement

Author(s): Heuer, Hilary W; Wang, P; Rascovsky, K; Wolf, A; Appleby, B; Bove, J; Bordelon, Y; Brannelly, P; Brushaber, DE; Caso, C; Coppola, G; Dickerson, B; Dickinson, S; Domoto-Reilly, K; Faber, K; Ferrall, J; Fields, J; Fishman, A; Fong, J; Foroud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8880125937f4973bdacfaffcace77a62
https://pubmed.ncbi.nlm.nih.gov/31914226

Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease

Autor: Christina Caso, Thomas J. Grabowski, Swati Rane, Brenna Cholerton, Cyrus P. Zabetian, John C. Oakley, Thomas J. Montine, Natalie Koh

Publikováno v: Parkinsonism Relat Disord

Introduction Imaging neurovascular disturbances in Parkinson's disease (PD) is an excellent measure of disease severity. Indeed, a disease-specific regional pattern of abnormal metabolism has been identified using positron emission tomography. Only a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87aa357dbb82312637f19f13f448e5b
https://pubmed.ncbi.nlm.nih.gov/32559629

Utility of the global CDR

Autor: Toji, Miyagawa, Danielle, Brushaber, Jeremy, Syrjanen, Walter, Kremers, Julie, Fields, Leah K, Forsberg, Hilary W, Heuer, David, Knopman, John, Kornak, Adam, Boxer, Howard J, Rosen, Bradley F, Boeve, Brian, Appleby, Yvette, Bordelon, Jessica, Bove, Patrick, Brannelly, Christina, Caso, Giovanni, Coppola, Reilly, Dever, Christina, Dheel, Bradford, Dickerson, Susan, Dickinson, Sophia, Dominguez, Kimiko, Domoto-Reilly, Kelley, Faber, Jessica, Ferrell, Ann, Fishman, Jamie, Fong, Tatiana, Foroud, Ralitza, Gavrilova, Debra, Gearhart, Behnaz, Ghazanfari, Nupur, Ghoshal, Jill S, Goldman, Jonathan, Graff-Radford, Neill, Graff-Radford, Ian, Grant, Murray, Grossman, Dana, Haley, Robin, Hsiung, Edward, Huey, David, Irwin, David, Jones, Lynne, Jones, Kejal, Kantarci, Anna, Karydas, Daniel, Kaufer, Diana, Kerwin, Ruth, Kraft, Joel, Kramer, Walter, Kukull, Irene, Litvan, Diane, Lucente, Codrin, Lungu, Ian, Mackenzie, Miranda, Maldonado, Masood, Manoochehri, Scott, McGinnis, Emily, McKinley, Mario F, Mendez, Bruce, Miller, Namita, Multani, Chiadi, Onyike, Jaya, Padmanabhan, Alexander, Pantelyat, Rodney, Pearlman, Leonard, Petrucelli, Madeline, Potter, Rosa, Rademakers, Eliana M, Ramos, Kate, Rankin, Katya, Rascovsky, Erik D, Roberson, Emily, Rogalski, Pheth, Sengdy, Leslie, Shaw, Maria C, Tartaglia, Nadine, Tatton, Joanne, Taylor, Arthur, Toga, John Q, Trojanowski, Ping, Wang, Sandra, Weintraub, Bonnie, Wong, Zbigniew, Wszolek

Publikováno v: Alzheimers Dement

INTRODUCTION: We created global rating scoring rules for the CDR® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD. METHODS: The CDR plus NACC FTLD rating was applied to 970 spo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6f4e0b7c34ab11a4905a5337d73d9cf
https://pubmed.ncbi.nlm.nih.gov/31914218