Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Christin Vielmuth"'
1
Akademický článek
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity
Autor: Michał Załuski, Dorota Łażewska, Piotr Jaśko, Ewelina Honkisz-Orzechowska, Kamil J. Kuder, Andreas Brockmann, Gniewomir Latacz, Małgorzata Zygmunt, Maria Kaleta, Beril Anita Greser, Agnieszka Olejarz-Maciej, Magdalena Jastrzębska-Więsek, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 18, p 13707 (2023)
Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we synthesized 25 novel xanthine derivatives with variable substituents at the N1-, N3- and C8-po
Externí odkaz: https://doaj.org/article/5963438b8d354c9ba124160cee724d87
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2
Akademický článek
Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
Autor: Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v: Biomolecules, Vol 13, Iss 7, p 1079 (2023)
Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B (MAO-B) inhibitors with significant ancillary A2A adenosine receptor (A2AAR)
Externí odkaz: https://doaj.org/article/a763a392789d4e87855485b3273ec76a
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3
Akademický článek
Irreversible Antagonists for the Adenosine A2B Receptor
Autor: Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E. Müller
Publikováno v: Molecules, Vol 27, Iss 12, p 3792 (2022)
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based on an 8-p-sulfophenylxanthine
Externí odkaz: https://doaj.org/article/d0d8be1988af4d15968751ab4b7f458a
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4
Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
Autor: Kieć-Kononowicz, Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna
Publikováno v: Biomolecules; Volume 13; Issue 7; Pages: 1079
Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B (MAO-B) inhibitors with significant ancillary A2A adenosine receptor (A2AAR)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5be6d2de3a815f8c4eda10f426b0f7cf
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5
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors
Autor: Pedro Valada, Sonja Hinz, Christin Vielmuth, Cátia R. Lopes, Rodrigo A. Cunha, Christa E. Müller, João Pedro Lopes
Publikováno v: Purinergic Signal
Inosine has robust neuroprotective effects, but it is unclear if inosine acts as direct ligand of adenosine receptors or if it triggers metabolic effects indirectly modifying the activity of adenosine receptors. We now combined radioligand binding st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8cb78cc0d623262b9eb75ce0a79ebe
https://europepmc.org/articles/PMC10247617/
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6
Irreversible Antagonists for the Adenosine A2B Receptor
Autor: Müller, Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E.
Publikováno v: Molecules; Volume 27; Issue 12; Pages: 3792
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based on an 8-p-sulfophenylxanthine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::9d64842034867f0c974a7b7b02269c69
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