Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.

Autor: Craig S Nowell, Nicholas Bredenkamp, Stéphanie Tetélin, Xin Jin, Christin Tischner, Harsh Vaidya, Julie M Sheridan, Frances Hogg Stenhouse, Raphaela Heussen, Andrew J H Smith, C Clare Blackburn

Publikováno v: PLoS Genetics, Vol 7, Iss 11, p e1002348 (2011)

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood. To examine the cellular and molecular basis of Foxn1 function, we

Externí odkaz: https://doaj.org/article/4f25ee44dc6b4291a990152910e524ce

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

Autor: C. Diana Peddie, C. Clare Blackburn, Craig S. Nowell, Christin Tischner, Nicholas Bredenkamp, Frances H. Stenhouse, Terri Gaskell, Kathy E. O'Neill, Harsh J. Vaidya

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151666 (2016)
PLoS ONE
O'Neill, K E, Bredenkamp, N, Tischner, C, Vaidya, H J, Stenhouse, F H, Peddie, C D, Nowell, C S, Gaskell, T & Blackburn, C C 2016, ' Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution ', PLoS ONE, vol. 11, no. 3, pp. e0151666 . https://doi.org/10.1371/journal.pone.0151666

Thymus function requires extensive cross-talk between developing T-cells and the thymic epithelium, which consists of cortical and medullary TEC. The transcription factor FOXN1 is the master regulator of TEC differentiation and function, and declinin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e20d68cb83c5689a139d1e6e2cb77e
http://europepmc.org/articles/PMC4794177?pdf=render

Translation and Assembly of Radiolabeled Mitochondrial DNA-Encoded Protein Subunits from Cultured Cells and Isolated Mitochondria

Autor: Luke E, Formosa, Annette, Hofer, Christin, Tischner, Tina, Wenz, Michael T, Ryan

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1351

In higher eukaryotes, the mitochondrial electron transport chain consists of five multi-subunit membrane complexes responsible for the generation of cellular ATP. Of these, four complexes are under dual genetic control as they contain subunits encode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b81fb8a09f44d2093c3bfe30bf603c96
https://pubmed.ncbi.nlm.nih.gov/26530678

Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders

Autor: Tina Wenz, Christin Tischner

Publikováno v: Mitochondrion. 24

Mitochondrial diseases are very heterogeneous in their genetic cause and clinical manifestation. During the last few decades progress has been made in the diagnosis of mitochondrial diseases, but an established therapy is so far lacking. Several expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d63a07c5dff756ef2d6ab2ba3c1287
https://pubmed.ncbi.nlm.nih.gov/26134435

Defining the action spectrum of potential PGC-1α activators on a mitochondrial and cellular level in vivo

Autor: Christin Tischner, Veronika Lellek, Tina Wenz, Astrid Schauß, Natalie Noe, Annette Hofer, Nikolay Kladt

Publikováno v: Human molecular genetics. 23(9)

Previous studies have demonstrated a therapeutic benefit of pharmaceutical PGC-1α activation in cellular and murine model of disorders linked to mitochondrial dysfunction. While in some cases, this effect seems to be clearly associated with boosting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d191c19bc0d96f117a3645882472c81
https://pubmed.ncbi.nlm.nih.gov/24334768