Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christin Riess"'
Autor:
Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclini
Externí odkaz:
https://doaj.org/article/b688d5f6f21b43c69fa8ffaf7d1c4143
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo
Externí odkaz:
https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27
Autor:
Christin Riess, Dirk Koczan, Björn Schneider, Charlotte Linke, Katharina del Moral, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Current therapeutic approaches have met limited clinical success for glioblastoma multiforme (GBM). Since GBM harbors genomic alterations in cyclin-dependent kinases (CDKs), targeting these structures with specific inhibitors (CDKis) is prom
Externí odkaz:
https://doaj.org/article/68fa0d1afbb74b2487585beff34bf5af
Autor:
Christin Riess, Björn Schneider, Hanna Kehnscherper, Julia Gesche, Nina Irmscher, Fatemeh Shokraie, Carl Friedrich Classen, Elisa Wirthgen, Grazyna Domanska, Annette Zimpfer, Daniel Strüder, Christian Junghanss, Claudia Maletzki
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients.
Externí odkaz:
https://doaj.org/article/84a6ad70899d454bb54e3837a71f103e
Autor:
Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 2, Pp 854-870 (2018)
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis. Arginine
Externí odkaz:
https://doaj.org/article/07deca83d7ef459f8c6b4a08e663e55f
Autor:
Christina Große-Thie, Christian Junghanss, Nina Irmscher, Carl Friedrich Classen, Inken Salewski, Daniel Strüder, Christin Riess, Claudia Maletzki
Publikováno v:
Cancer Metastasis Reviews
Cyclin-dependent kinases (CDK) control the cell cycle and play a crucial role in oncogenesis. Pharmacologic inhibition of CDK has contributed to the recent clinical approval of dual CDK4/6 inhibitors for the treatment of breast and small cell lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743ba215858342dbd013b42ef1e7304a
https://doi.org/10.1007/s10555-020-09940-4
https://doi.org/10.1007/s10555-020-09940-4
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Markus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N Lode, Nadja Engel, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Neuro-Oncology. 24:i62-i63
INTRODUCTION/BACKGROUND: Glioblastoma multiforme show constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy. This renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase from Strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686d1cc9bda3a10ab3f27c0a2b086190
https://doi.org/10.1093/neuonc/noac079.228
https://doi.org/10.1093/neuonc/noac079.228
Autor:
Mareike Krause, Heiko Lemcke, Michael W. Müller, Christina Grosse-Thie, Christin Riess, Björn Schneider, Inken Salewski, Claudia Maletzki, Nadja Engel, Nina Schoenwaelder, Christian Junghanss, Anna Skorska
Publikováno v:
Cancers
Volume 13
Issue 10
Cancers, Vol 13, Iss 2396, p 2396 (2021)
Volume 13
Issue 10
Cancers, Vol 13, Iss 2396, p 2396 (2021)
Simple Summary This study examined the therapeutic potential of a combined therapy approach, based on clinical approved drugs (5-FU, Cisplatin, cetuximab) and cyclin-dependent kinase inhibitors (CDKi, dinaciclib, palbociclib, THZ1). We identified ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab15f8ae7feb35a05ae8f1b3dd6f4e
Publikováno v:
Annals of Oncology. 32:S368
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3827c479b796e202df4c292da432b1
https://doi.org/10.1016/j.annonc.2021.08.303
https://doi.org/10.1016/j.annonc.2021.08.303
Publikováno v:
Neuro-Oncology
INTRODUCTION Current therapeutic approaches have limited clinical success for Glioblastoma patients, making novel strategies urgent. Cyclin-dependent kinases (CDK) are crucial in cell cycle, oncogenic transcription, DNA repair, and stem-cell renewal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9a1a3c2dc3d034abcb5bacec68de41
http://europepmc.org/articles/PMC7715447
http://europepmc.org/articles/PMC7715447