Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Christin M. Yingling"'
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Akademický článek
Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer
Autor: Philip J. Kuehl, Christin M. Yingling, Devon Dubose, Michael Burke, David A. Revelli, Wenshu Chen, Wendy W. Dye, Steven A. Belinsky, Mathewos Tessema
Publikováno v: Drug Delivery, Vol 28, Iss 1, Pp 767-775 (2021)
Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The phar
Externí odkaz: https://doaj.org/article/dc02d998734d408f9f931094d9d32474
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7
Data from Carcinogen-Induced Gene Promoter Hypermethylation Is Mediated by DNMT1 and Causal for Transformation of Immortalized Bronchial Epithelial Cells
Autor: Steven A. Belinsky, Jun Nakamura, Paul E. Romo, Shuguang Leng, Christin M. Yingling, Leah A. Damiani
A better understanding of key molecular changes during transformation of lung epithelial cells could affect strategies to reduce mortality from lung cancer. This study uses an in vitro model to identify key molecular changes that drive cell transform
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c04456ce68021f1b9922ad6134d776
https://doi.org/10.1158/0008-5472.c.6498174
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8
Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer
Autor: Mathewos Tessema, Steven A. Belinsky, Wendy W Dye, Wenshu Chen, David Revelli, Devon B Dubose, Christin M. Yingling, Michael Burke, Philip J. Kuehl
Publikováno v: Drug Delivery, Vol 28, Iss 1, Pp 767-775 (2021)
Drug Delivery
article-version (VoR) Version of Record
Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The phar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5a00120d912c6021195b3c083e91f2
https://doaj.org/article/dc02d998734d408f9f931094d9d32474
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9
Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients
Autor: Yong Lin, Scott H. Randell, Hans Petersen, Maria A. Picchi, Steven A. Belinsky, Yohannes Tesfaigzi, Mathewos Tessema, Dereje D. Tassew, Guodong Wu, Christin M. Yingling, Kieu Do
Publikováno v: Lung Cancer
Objectives Smoking is a common risk factor for chronic obstructive pulmonary disease (COPD) and lung cancer. Although COPD patients have higher risk of lung cancer compared to non-COPD smokers, the molecular links between these diseases are not well-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acd2079af2fa9104d36f4db791fe635
https://doi.org/10.1016/j.lungcan.2020.05.017
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10
Cytotoxicity and Genotoxicity of E-Cigarette Generated Aerosols Containing Diverse Flavoring Products and Nicotine in Oral Epithelial Cell Lines
Autor: Shosei Kishida, Cindy L. Thomas, Wendy W Dye, Steven A. Belinsky, Carmen S. Tellez, Kieu Do, Guodong Wu, Daniel E. Juri, Tohru Kiyono, Loryn M Phillips, Christin M. Yingling
Publikováno v: Toxicol Sci
Electronic cigarettes are the most commonly used nicotine containing product among teenagers. The oral epithelium is the first site of exposure and our recent work revealed considerable diversity among e-liquids for composition and level of chemical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823e63d4b5ea6fef05e61e2a060057ed
https://pubmed.ncbi.nlm.nih.gov/33226417
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