Výsledky vyhledávání - "Christin Christensen"

Inhibition of cGMP-Dependent Protein Kinase Reduces the Response to Sonic Hedgehog in Neuralized Embryoid Bodies

Autor: Shile Zhang, Christin Christensen, Henk Roelink

Publikováno v: Stem Cells and Development. 15:647-654

Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60db7b1bef5b48876b1a2e6bc11564a7
https://doi.org/10.1089/scd.2006.15.647

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Abstract 3237: Evaluation of the pharmacokinetics and efficacy of a novel pro-drug of the HSP90 inhibitor, MPC-3100, designed with improved solubility

Autor: Leslie Reeves, Rajendra P. Tangallapally, Daniel P. Parker, Se-Ho Kim, Damon I. Papac, In Chul Kim, Brian Clemetson, Brian Hachey, Richard Trovato, Chad Bradford, J. Scott Patton, Vijay Baichwal, Ashok C. Bajji, Lynn DeMie, Daniel Wettstein, Christin Christensen

Publikováno v: Cancer Research. 71:3237-3237

MPC-3100 is a synthetic, orally bioavailable HSP90 inhibitor in clinical development. The low solubility of this compound requires a solubility enhancing agent to enable uniform oral bioavailability. A pro-drug of MPC-3100 with enhanced aqueous solub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::425bdacb30bf4be8abc482c57c1e378a
https://doi.org/10.1158/1538-7445.am2011-3237

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