Supplemental Figures S1-S7 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice

Autor: Peter-Michael Kloetzel, Gerald Willimsky, Thomas Blankenstein, Ulrike Seifert, Ana Textor, Anja A. Kühl, Christin Keller, Karin Schmidt

File contains supplementary figures showing TAP-specific peptide translocation, growth of WT and Erap1-/- HCC in different recipients, gating strategy for T cell analysis, antigen-dependent T cell expansion, rejection of WT and Erap1-/- HCC through p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708fe0cf624e1739f65d3e48ccabf544
https://doi.org/10.1158/0008-5472.22417182

Data from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice

Autor: Peter-Michael Kloetzel, Gerald Willimsky, Thomas Blankenstein, Ulrike Seifert, Ana Textor, Anja A. Kühl, Christin Keller, Karin Schmidt

Cytotoxic T lymphocytes can reject established tumors if their target peptide is efficiently presented by MHC class I molecules (pMHC-I) on the surface of cancerous cells. Therapeutic success upon adoptive T-cell transfer (ATT), however, requires add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2ce45d6b350dad8f3d7f7a601aa50d
https://doi.org/10.1158/0008-5472.c.6509766

Adult human liver contains intermediate-type proteasomes with different enzymatic properties

Autor: Sabrina Gohlke, Alexander Kloβ, Michael Tsokos, Kathrin Textoris-Taube, Christin Keller, Peter-Michael Kloetzel, Burkhardt Dahlmann

Publikováno v: Annals of Hepatology, Vol 13, Iss 4, Pp 429-438 (2014)

Background. The 20S proteasome is the proteolytic core of the major intracellular protein degradative system, the ubiquitin-proteasome system. Since little is known about proteasomes of human liver, we have investigated the proteasome spectrum in adu

Externí odkaz: https://doaj.org/article/c65759fc46eb4736a91d46369d47c89f

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35-specific T-cell recognition

Autor: Antje Sucker, Martin Keller, Xenia Gorny, Annette Paschen, Elke Bürger, Elke Krüger, Loredana Saveanu, Tanja Dannenberg, Antje Voigt, Christin Keller, Kathrin Textoris-Taube, Hermann-Josef Rothkötter, Petra Henklein, Peter-Michael Kloetzel, Frédéric Ebstein, Ulrike Seifert, Ulrike Kuckelkorn, Sabrina Urban, Burkhardt Dahlmann, Fang Zhao

Publikováno v: European Journal of Immunology. 45:3257-3268

The immunodominant MART-1(26(27)-35) epitope, liberated from the differentiation antigen melanoma antigen recognized by T cells/melanoma antigen A (MART-1/Melan-A), has been frequently targeted in melanoma immunotherapy, but with limited clinical suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12cc257838d02cd2da701cec60148ee4
https://doi.org/10.1002/eji.201445243

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection

Autor: Peter M. Kloetzel, Michele Mishto, Alice J. A. M. Sijts, Kathrin Textoris-Taube, Hanna H. Schalkwijk, Juliane Liepe, Anouk C.M. Platteel, Rebeca Cardoso, Petra Henklein, Christin Keller

Publikováno v: Cell Reports, Vol 20, Iss 5, Pp 1242-1253 (2017)
Platteel, A C M, Liepe, J, Textoris-Taube, K, Keller, C, Henklein, P, Schalkwijk, H H, Cardoso, R, Kloetzel, P M, Mishto, M & Sijts, A J A M 2017, ' Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection ', Cell Reports, vol. 20, no. 5, pp. 1242-1253 . https://doi.org/10.1016/j.celrep.2017.07.026
Cell Reports
Cell Reports, 20(5), 1242. Elsevier Saunders

Summary: Proteasome-catalyzed peptide splicing (PCPS) generates peptides that are presented by MHC class I molecules, but because their identification is challenging, the immunological relevance of spliced peptides remains unclear. Here, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78882a1652debb3b238119168406beaf
https://doi.org/10.1016/j.celrep.2017.07.026