Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christie Ann McCarl"'
Autor:
Nadine Norton, Nicholas Fox, Christie-Ann McCarl, Kathleen S. Tenner, Karla Ballman, Courtney L. Erskine, Brian M. Necela, Donald Northfelt, Winston W. Tan, Carmen Calfa, Mark Pegram, Gerardo Colon-Otero, Edith A. Perez, Raphael Clynes, Keith L. Knutson
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-9 (2018)
Abstract Background Resected HER2 breast cancer patients treated with adjuvant trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. We previously showed that trastuzumab and chemotherapy induce HER
Externí odkaz:
https://doaj.org/article/1c1febf941ce45ac8dcb2e8d12e66fb8
Autor:
Agnes Gardet, Alex Pellerin, Christie-Ann McCarl, Rohan Diwanji, Wenting Wang, Douglas Donaldson, Nathalie Franchimont, Victoria P. Werth, Dania Rabah
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Objective: Plasmacytoid dendritic cells (pDCs) are a major source of Type-I Interferon (IFN-I), a key driver in cutaneous lupus erythematosus (CLE). Currently evaluated in Phase II clinical trial, 24F4A (BIIB059) is an antibody targeting BDCA2, an in
Externí odkaz:
https://doaj.org/article/d4c5a43a4a3847498b3050a9c21c46e7
Autor:
Patrick Cullen, Chelsea Parker Harp, Jorge Vera Rebollar, Taylor L. Reynolds, Rebecca Basile, Christie-Ann McCarl, Benjamin A. Smith, Angela Li, Jeremy C. Burns, John Silbereis, Jing Zhu, Ellen Cahir-McFarland, Alex Pellerin, Michael Mingueneau, Stephen J Rubino, Hao Tang, Nathalie Franchimont, Thomas M. Carlile, Baohong Zhang, Jennifer Sybulski, Thomas O. Cameron, Kathryn Pellerin, Richard M. Ransohoff, Luke Jandreski
Publikováno v:
Brain : a journal of neurology. 144(8)
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibod
Autor:
Winston Tan, Nadine Norton, Kathleen S. Tenner, Gerardo Colon-Otero, Courtney L. Erskine, Nicholas Fox, Donald W. Northfelt, Brian M. Necela, Raphael Clynes, Edith A. Perez, Christie Ann McCarl, Carmen Calfa, Mark D. Pegram, Keith L. Knutson, Karla V. Ballman
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-9 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Resected HER2 breast cancer patients treated with adjuvant trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. We previously showed that trastuzumab and chemotherapy induce HER2-specifi
Autor:
Dania Rabah, Christie-Ann McCarl, Agnes Gardet, Rohan Diwanji, Victoria P. Werth, Douglas Donaldson, Alex Pellerin, Nathalie Franchimont, Wenting Wang
Publikováno v:
Abstracts Accepted for Publication.
Background: BIIB059 (aka 24F4A) is a monoclonal antibody that targets BDCA2, an inhibitory receptor expressed on pDCs. Plasmacytoid dendritic cells (pDCs) are a major source of Type-I Interferon (IFN-I), which is considered to be a key pathogenic dri
Autor:
Santosh Vardhana, Christie-Ann McCarl, Jung-Eun Jang, Janelle Waite, Michael L. Dustin, Thomas O. Cameron, Stefan Feske, Patrick J. Shaw
Entry of lymphocytes into secondary lymphoid organs (SLOs) involves intravascular arrest and intracellular calcium ion ([Ca(2+)]i) elevation. TCR activation triggers increased [Ca(2+)]i and can arrest T-cell motility in vitro. However, the requiremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075e99e5936f21242ba2f5df90d8ebce
https://ora.ox.ac.uk/objects/uuid:5bced5cb-67f7-4bd8-935a-ef61325a3ad7
https://ora.ox.ac.uk/objects/uuid:5bced5cb-67f7-4bd8-935a-ef61325a3ad7
Autor:
Stephan Ehl, Anne Rensing-Ehl, Yenan T. Bryceson, Christie-Ann McCarl, Birthe Jessen, Sebastian Fuchs, Stefan Feske, Markus Hufnagel, Hanspeter Pircher, Stephanie M. Wood, Cyril Fauriat, Andrea Maul-Pavicic, Klaus Schwarz, Katsuhiko Mikoshiba, Wolfgang W. A. Schamel, Samuel C. C. Chiang, Ilka Schulze, Thilo Bass, Sebastian Sjöqvist
Publikováno v:
Proceedings of the National Academy of Sciences. 108:3324-3329
Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Natural kil
Autor:
Stefan Feske, Claire Hivroz, Gideon Rechavi, Anjana Rao, Capucine Picard, Alexander Papolos, Francoise LeDeist, Frédéric Rieux-Laucat, Kevin Lüthy, Alain Fischer, Christie Ann McCarl, Sara Khalil
Publikováno v:
New England Journal of Medicine. 360:1971-1980
A mutation in ORAI1, the gene encoding the pore-forming subunit of the Ca(2+)-release-activated Ca(2+) (CRAC) channel, abrogates the store-operated entry of Ca(2+) into cells and impairs lymphocyte activation. Stromal interaction molecule 1 (STIM1) i
T cell function is dependent on store-operated Ca2+ influx that is activated by the stromal interaction molecules (STIM) 1 and 2. We show that mice with T-cell specific deletion of STIM1 or STIM2 are protected from experimental autoimmune encephalomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d05faffbd418a207ffba7b289c7c1a
https://europepmc.org/articles/PMC3517124/
https://europepmc.org/articles/PMC3517124/
Autor:
Courtney L. Erskine, Keith L. Knutson, Carmen Julia Calfa, Mark D. Pegram, Susan V. Sumrall, Donald W. Northfelt, Karla V. Ballman, Raphael Clynes, Winston Tan, Nadine Norton, Nicholas Fox, Edith A. Perez, Christie-Ann McCarl
Publikováno v:
Journal of Clinical Oncology. 31:522-522
522 Background: In the adjuvant setting, patients with HER2 breast cancer treated with trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy alone. We previously showed that trastuzumab and chemotherapy in