Mechanical loading modulates phosphate related genes in rat bone

Autor: Ashwini Kumar Nepal, Hubertus W. van Essen, Christianne M. A. Reijnders, Paul Lips, Nathalie Bravenboer

Publikováno v: PLoS ONE, Vol 18, Iss 3 (2023)

Mechanical loading determines bone mass and bone structure, which involves many biochemical signal molecules. Of these molecules, Mepe and Fgf23 are involved in bone mineralization and phosphate homeostasis. Thus, we aimed to explore whether mechanic

Externí odkaz: https://doaj.org/article/70cd64fe4e784506ba674d9fc8d3dcdb

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

Autor: Christianne M. A. Reijnders, Lijc Lambert Bergers, Lenie J. van den Broek, Susan Gibbs

Publikováno v: Stem Cell Reviews and Reports, 13(3), 418-429. Humana Press
Stem Cell Reviews
Stem cell reviews and reports, 13(3), 418-429. Humana Press
van den Broek, L J, Bergers, L I J C, Reijnders, C M A & Gibbs, S 2017, ' Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges ', Stem cell reviews and reports, vol. 13, no. 3, pp. 418-429 . https://doi.org/10.1007/s12015-017-9737-1
van den Broek, L J, Bergers, L I J C, Reijnders, C M A & Gibbs, S 2017, ' Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges ', Stem Cell Reviews and Reports, vol. 13, no. 3, pp. 418-429 . https://doi.org/10.1007/s12015-017-9737-1

Understanding the healthy and diseased state of skin is important in many areas of basic and applied research. Although the field of skin tissue engineering has advanced greatly over the last years, current in vitro skin models still do not mimic the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e535e389190b621968af6ce898483db
https://research.vumc.nl/en/publications/4535914c-0e86-4f33-866a-d702e4df7c5e

Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts

Autor: Sander W. Spiekstra, Susan Gibbs, Jeroen Kees Buskermolen, Thorsten Steinberg, Christianne M. A. Reijnders, Albert J. Feilzer, Astrid D. Bakker, Cornelis J. Kleverlaan

Publikováno v: Tissue Engineering Part C. Methods, 22(8), 781-791. Mary Ann Liebert Inc.
Buskermolen, J K, Reijnders, C M A, Spiekstra, S W, Steinberg, T, Kleverlaan, C J, Feilzer, A J, Bakker, A D & Gibbs, S 2016, ' Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts ', Tissue Engineering Part C. Methods, vol. 22, no. 8, pp. 781-791 . https://doi.org/10.1089/ten.tec.2016.0066
Tissue Engineering, Part. C Methods, 22(8), 781-791. Mary Ann Liebert Inc.
Buskermolen, J K, Reijnders, C M A, Spiekstra, S W, Steinberg, T, Kleverlaan, C J, Feilzer, A J, Bakker, A D & Gibbs, S 2016, ' Development of a full-thickness human gingiva equivalent constructed from immortalized keratinocytes and fibroblasts ', Tissue Engineering. Part C, Methods, vol. 22, no. 8, pp. 781-791 . https://doi.org/10.1089/ten.tec.2016.0066
Tissue Engineering. Part C, Methods
Tissue Engineering. Part C, Methods, 22(8), 781-791. Mary Ann Liebert Inc.

Organotypic models make it possible to investigate the unique properties of oral mucosa in vitro. For gingiva, the use of human primary keratinocytes (KC) and fibroblasts (Fib) is limited due to the availability and size of donor biopsies. The use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a175a966e8afc22e20bebce5a90094
https://research.vumc.nl/en/publications/e27ec153-1681-4d7d-aeca-d4d494f4b818

In Vivo Mechanical Loading Modulates Insulin-Like Growth Factor Binding Protein-2 Gene Expression in Rat Osteocytes

Autor: Paul Lips, Christianne M. A. Reijnders, Nathalie Bravenboer, P. J. Holzmann, Marinus A. Blankenstein, F. Bhoelan

Publikováno v: Calcified Tissue International, 80(2), 137-143. Springer New York
Calcified Tissue International
Reijnders, C M A, Bravenboer, N, Holzmann, P J, Bhoelan, F, Blankenstein, M A & Lips, P 2007, ' In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes ', Calcified Tissue International, vol. 80, no. 2, pp. 137-143 . https://doi.org/10.1007/s00223-006-0077-4

Mechanical stimulation is essential for maintaining skeletal integrity. Mechanosensitive osteocytes are important during the osteogenic response. The growth hormone-insulin-like growth factor (GH-IGF) axis plays a key role during regulation of bone f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ea68e8bd96786c97bba04d1414235f
https://doi.org/10.1007/s00223-006-0077-4

Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture

Autor: Marieke L. Kuijjer, Anne-Marie Cleton-Jansen, Arjan C. Lankester, Karoly Szuhai, Helene Roelofs, Pancras C.W. Hogendoorn, Christianne M. A. Reijnders, Emilie P. Buddingh, R. Maarten Egeler, S. Eriaty N. Ruslan

Publikováno v: Clinical Sarcoma Research

Background In vitro expanded mesenchymal stromal cells (MSCs) are increasingly used as experimental cellular therapy. However, there have been concerns regarding the safety of their use, particularly with regard to possible oncogenic transformation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e21598aabc2a8c1b11d1eadedf37a48
https://doi.org/10.1186/s13569-015-0031-1