Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christiane Wirbelauer"'
Autor:
Sebastian Kaluscha, Silvia Domcke, Christiane Wirbelauer, Michael B. Stadler, Sevi Durdu, Lukas Burger, Dirk Schübeler
Publikováno v:
Nature Genetics. 54:1895-1906
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats in mammalian genomes. To what extent this entails direct inhibition of transcription factor (TF) binding versus indirect inhibition via recruitment of methyl-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2985aaf6b5aeebfcacdd0b9419894bd7
https://doi.org/10.1038/s41588-022-01241-6
https://doi.org/10.1038/s41588-022-01241-6
Autor:
Tuncay Baubec, Arnaud R Krebs, Dirk Schübeler, Lukas Burger, Christiane Wirbelauer, Luke Isbel, Dominik Hartl, Ralph S. Grand
Publikováno v:
Genome Research
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is unknown to what extent the CpG dinucleotide itself actually contributes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4370c8597a19dd0820f25a2c5418aefd
https://doi.org/10.5167/uzh-168112
https://doi.org/10.5167/uzh-168112
Autor:
Christian Beisel, Christiane Wirbelauer, Renato Paro, Vijay K. Tiwari, Michael B. Stadler, Dirk Schübeler
Publikováno v:
Nature Genetics. 44:94-100
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH(2)-terminal kinase (JNK) pathway exemplifies one subgroup of the mitogen-activated protein (MAP) kinases, which, besides having established functions in stress response, als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e77891497e7cca6c0901a036006bea7
https://doi.org/10.1038/ng.1036
https://doi.org/10.1038/ng.1036
Autor:
Marc Hild, Christiane Wirbelauer, Annette N. D. Scharf, Stephen P. Bell, Antoine H.F.M. Peters, Dan Garza, Dirk Schübeler, Frederic Zilbermann, Fred van Leeuwen, Axel Imhof, M. Schwaiger, David M. MacAlpine, Oliver Bell
Publikováno v:
The EMBO Journal. 26:4974-4984
Post-translational modifications of histones are involved in transcript initiation and elongation. Methylation of lysine 36 of histone H3 (H3K36me) resides promoter distal at transcribed regions in Saccharomyces cerevisiae and is thought to prevent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a288008f2e353cc219b24e1782afc213
https://doi.org/10.1038/sj.emboj.7601926
https://doi.org/10.1038/sj.emboj.7601926
Autor:
Joanna Lisztwan, Claudio R. Thoma, Christiane Wirbelauer, Alexander Hergovich, Robert E. Barry, Wilhelm Krek
Publikováno v:
Molecular and Cellular Biology. 26:5784-5796
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is linked to the development of tumors of the eyes, kidneys, and central nervous system. VHL encodes two gene products, pVHL30 and pVHL19, of which one, pVHL30, associates functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8361020470edb40c884ab95910a2af38
https://doi.org/10.1128/mcb.00232-06
https://doi.org/10.1128/mcb.00232-06
Autor:
Martin Scheffner, Christiane Wirbelauer, Andrea Michael Meyer, Daniel Hess, Ulrike Kogel, Wilhelm Krek, Abdelmajid Sabile
Publikováno v:
Molecular and Cellular Biology. 26:5994-6004
Work over the past decades has delineated many of the key components of the principle pathways that control mammalian G1 progression, including the D- and E-type cyclins and their associated cyclin-dependent protein kinases (CDKs), CDK4/6 and CDK2, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2a9a86f0ff4bc287ed963bb9eecb41
https://doi.org/10.1128/mcb.01630-05
https://doi.org/10.1128/mcb.01630-05
Publikováno v:
Genes & Development. 19:1761-1766
Deposition of variant histones provides a mechanism to reset and to potentially specify chromatin states. We determined the distribution of H3 and its variant H3.3 relative to chromatin structure and elongating polymerase. H3.3 is enriched throughout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20f92f71717702ba689e3dd8bce89f2
https://doi.org/10.1101/gad.347705
https://doi.org/10.1101/gad.347705
Publikováno v:
Molecular Cell. 13(1):101-111
The AU-rich element (ARE) in the 3′ untranslated region of unstable mRNAs mediate their rapid degradation. ARE binding proteins (AUBPs) have been described that either stabilize or otherwise degrade ARE-mRNAs by recruiting the exosome, a complex of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682c0a3b816f96e3225b3c3ab6c037c1
Autor:
Brian Luke, Christiane Wirbelauer, Marc Blondel, Daniel Hess, Edward J. Oakeley, Wilhelm Krek, Matthias Gstaiger, Marc Vigneron, Matthias Peter
Publikováno v:
Science. 302:1208-1212
Prefoldins (PFDs) are members of a recently identified, small–molecular weight protein family able to assemble into molecular chaperone complexes. Here we describe an unusually large member of this family, termed URI, that forms complexes with othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ef82877a6e1a2fe5987b19d3018be3
https://doi.org/10.1126/science.1088401
https://doi.org/10.1126/science.1088401
Autor:
Arnaud R Krebs, Dirk Schübeler, Tuncay Baubec, Daniele F Colombo, Juliane Schmidt, Altuna Akalin, Lukas Burger, Christiane Wirbelauer
Publikováno v:
Nature. 520(7546)
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731181071cc90bc69e612d6f5ce1fcfc
https://pubmed.ncbi.nlm.nih.gov/25607372
https://pubmed.ncbi.nlm.nih.gov/25607372