Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christiane Wiesner"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The actomyosin cytoskeleton plays an important role in polarised cell migration. Here the authors identify lymphocyte-specific protein (LSP)-1 as a regulator of actomyosin contractility in macrophages, by competing with supervillin for myosin IIA act
Externí odkaz:
https://doaj.org/article/f3f5c58257864c0498c0aecf08fa9c52
Autor:
Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40742 (2012)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
Externí odkaz:
https://doaj.org/article/d5eaa5f72a81446caa82d85295dc8909
Autor:
Miriam Stölting, Christiane Wiesner, Vanessa van Vliet, Elke Butt, Hermann Pavenstädt, Stefan Linder, Joachim Kremerskothen
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35340 (2012)
Eukaryotic cells form a variety of adhesive structures to connect with their environment and to regulate cell motility. In contrast to classical focal adhesions, podosomes, highly dynamic structures of different cell types, are actively engaged in ma
Externí odkaz:
https://doaj.org/article/3dd46816025347d79454ca83923c27b3
Publikováno v:
Grundwasser. 26:47-60
Zur strategischen Planung der Grundwasserbewirtschaftung am Wasserwerk Colbitz wurden modellgestutzte wasserhaushaltliche Untersuchungen durchgefuhrt. Das heutige gewinnbare Grundwasserdargebot aus Grundwasserneubildung und Grundwasseranreicherung un
Publikováno v:
The Journal of Cell Biology
The authors find that matrix metalloproteinase MT1-MMP is enriched at the plasma membrane of macrophage podosomes, where it persists beyond podosome lifetime and, through binding to the subcortical actin cytoskeleton, forms subcellular signposts that
Autor:
Isabelle Maridonneau-Parini, Stefan Linder, Karim El Azzouzi, Véronique Le-Cabec, Christiane Wiesner
Publikováno v:
Cell Adhesion & Migration. 8:179-191
Migration of macrophages is a key process for a variety of physiological functions, such as pathogen clearance or tissue homeostasis. However, it can also be part of pathological scenarios, as in the case of tumor-associated macrophages. This review
Autor:
Christiane Wiesner, Tobias B. Huber, Elisabeth Génot, Stefan Linder, Joachim Kremerskothen, Edith Reuzeau, Miriam Stölting, Vanessa van Vliet, Hermann Pavenstädt, Patricia Rottiers, Adelheid Korb-Pap
Publikováno v:
The FASEB Journal. 25:505-514
Podosomes are highly dynamic structures that are involved in cell adhesion and extracellular matrix remodeling. They present as intracellular columns composed of an actin-rich core region and a surrounding ring-like structure containing focal adhesio
Publikováno v:
Blood. 116:1559-1569
The matrix metalloproteinase (MMP) MT1-MMP plays pivotal roles in leukocyte physiology such as monocyte diapedesis, dendritic cell migration, and T-cell homing. MT1-MMP is a surface-anchored “master switch” proteinase that cleaves a variety of su
Autor:
Stefan Linder, Christiane Wiesner
Publikováno v:
Cellular and molecular life sciences : CMLS. 72(1)
Podosomes are adhesion and invasion structures that are particularly prominent in cells of the monocytic lineage such as macrophages, dendritic cells, and osteoclasts. They are multifunctional organelles that combine several key abilities required fo
Publikováno v:
Journal of cell science. 126(Pt 13)
The matrix metalloproteinase MT1-MMP has a major impact on invasive cell migration in both physiological and pathological settings such as immune cell extravasation or metastasis of cancer cells. Surface-associated MT1-MMP is able to cleave component