Highly Specific and Sensitive Target Binding by the Humanized pS396-Tau Antibody hC10.2 Across a Wide Spectrum of Alzheimer’s Disease and Primary Tauopathy Postmortem Brains

Autor: Lone Helboe, Nina Rosenqvist, Christiane Volbracht, Lars Ø. Pedersen, Jan T. Pedersen, Søren Christensen, Jan Egebjerg, Claus T. Christoffersen, Benny Bang-Andersen, Thomas G. Beach, Geidy E. Serrano, Jeppe Falsig

Publikováno v: Journal of Alzheimer's Disease. 88:207-228

Background: Deposits of hyperphosphorylated tau fibrils are hallmarks of a broad spectrum of tauopathies, including Alzheimer’s disease (AD). Objective: To investigate heterogeneity of tau pathology across brain extracts from a broad selection of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b02055038581d809760d2e5e312230
https://doi.org/10.3233/jad-220125

Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s Disease

Autor: Allan Stensballe, Kenneth Kastaniegaard, Christiane Volbracht, Joakim Bastrup, Ayodeji A. Asuni

Publikováno v: Bastrup, J, Kastaniegaard, K, Asuni, A A, Volbracht, C & Stensballe, A 2020, ' Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 73, no. 1, pp. 393-411 . https://doi.org/10.3233/JAD-190652

Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The main constituent of amyloid plaques is amyloid-β peptides, but a complex interplay of other infiltrating proteins also co-localizes. We hypothesized that proteomic analysis co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf8ca80eac3e13babdf8755e474e5a8
https://doi.org/10.3233/jad-190652

Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease

Autor: Joakim Bastrup, Kathrine H Hansen, Christiane Volbracht, Søren Christensen, Kenneth Kastaniegaard, Ayodeji A. Asuni, Dorthe Belling, Lone Helboe, Allan Stensballe, Thomas Poulsen

Publikováno v: Bastrup, J, Hansen, K H, Poulsen, T B G, Kastaniegaard, K, Asuni, A A, Christensen, S, Belling, D, Helboe, L, Stensballe, A & Volbracht, C 2021, ' Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 79, no. 1, pp. 249-265 . https://doi.org/10.3233/jad-200715

Background: Alzheimer’s disease (AD) is characterized by accumulation of amyloid-β (Aβ) species and deposition of senile plaques (SPs). Clinical trials with the anti-Aβ antibody aducanumab have been completed recently. Objective: To characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba9cfa3ea8f4a13ffa41e6d8f095d5f
https://pubmed.ncbi.nlm.nih.gov/33252074

Dual strategy for reduced signal-suppression effects in matrix-assisted laser desorption/ionization mass spectrometry imaging

Autor: Joakim Bastrup, Allan Stensballe, Christiane Volbracht, Ayodeji A. Asuni, Svend Birkelund

Publikováno v: Bastrup, J, Birkelund, S, Asuni, A, Volbracht, C & Stensballe, A 2019, ' Dual strategy for reduced signal-suppression effects in matrix-assisted laser desorption/ionization mass spectrometry imaging ', Rapid communications in mass spectrometry : RCM, vol. 33, no. 22, pp. 1711-1721 . https://doi.org/10.1002/rcm.8521

RATIONALE: The molecular complexity of tissue features several signal-suppression effects which reduce the ionization of analytes significantly and thereby weakens the quality of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d62807aa9a365ca5499fa796fa4c36e
https://vbn.aau.dk/da/publications/4928926f-8113-4a9c-8577-fac256503983

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

Autor: Karsten Skjødt, Jan Egebjerg, Jan Torleif Pedersen, Fredrik Kartberg, Christiane Volbracht, Florence Sotty, Nina Helen Rosenqvist, Lars Østergaard Pedersen, Einar M. Sigurdsson, Ayodeji A. Asuni, Pia Jul, Christian Rungsted Andersson, Jeppe Falsig, Lone Helboe, Jeffrey B. Stavenhagen, Justus Claus Alfred Daechsel, Søren Christensen

Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Rosenqvist, N, Asuni, A A, Andersson, C R, Christensen, S, Daechsel, J A, Egebjerg, J, Falsig, J, Helboe, L, Jul, P, Kartberg, F, Pedersen, L Ø, Sigurdsson, E M, Sotty, F, Skjødt, K, Stavenhagen, J B, Volbracht, C & Pedersen, J T 2018, ' Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau ', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4, pp. 521-534 . https://doi.org/10.1016/j.trci.2018.09.005

Introduction: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD) and other tauopathies.Methods: Highly specific and selective anti-pS396-tau antibodies hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4e509d5c60e3458f1a368b67631b5a
https://pubmed.ncbi.nlm.nih.gov/30386817