Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Christiane Reitz"'
Autor:
Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, Jeffery M Vance
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1009977 (2022)
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in risk between African and European populations lies in the ancestral genomic background surrou
Externí odkaz:
https://doaj.org/article/676d82a2c6bb4f54b1906a924bb55aa3
Autor:
Rong Cheng, Min Tang, Izri Martinez, Temitope Ayodele, Penelope Baez, Dolly Reyes‐Dumeyer, Rafael Lantigua, Martin Medrano, Ivonne Jimenez‐Velazquez, Joseph H. Lee, Gary W. Beecham, Christiane Reitz
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 554-562 (2018)
Abstract Introduction Less than 10% of early‐onset Alzheimer's disease (EOAD) is explained by known mutations. Methods We conducted genetic linkage analysis of 68 well‐phenotyped Caribbean Hispanic families without clear inheritance patterns or m
Externí odkaz:
https://doaj.org/article/144f8e8ff98c4fa4aacd2b0a10ec02c1
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.
Autor:
Farid Rajabli, Briseida E Feliciano, Katrina Celis, Kara L Hamilton-Nelson, Patrice L Whitehead, Larry D Adams, Parker L Bussies, Clara P Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E Byfield, Carolina B Sierra Lopez, Jacob L McCauley, Heriberto Acosta, Angel Chinea, Brian W Kunkle, Christiane Reitz, Lindsay A Farrer, Gerard D Schellenberg, Badri N Vardarajan, Jeffery M Vance, Michael L Cuccaro, Eden R Martin, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, Margaret A Pericak-Vance
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007791 (2018)
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of Europea
Externí odkaz:
https://doaj.org/article/2cfb57bc74d14fa1b2c97c399c7244b7
Autor:
Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Denise Harold, Lesley Jones, Peter Holmans, Amy Gerrish, Alexey Vedernikov, Alexander Richards, Anita L DeStefano, Jean-Charles Lambert, Carla A Ibrahim-Verbaas, Adam C Naj, Rebecca Sims, Gyungah Jun, Joshua C Bis, Gary W Beecham, Benjamin Grenier-Boley, Giancarlo Russo, Tricia A Thornton-Wells, Nicola Denning, Albert V Smith, Vincent Chouraki, Charlene Thomas, M Arfan Ikram, Diana Zelenika, Badri N Vardarajan, Yoichiro Kamatani, Chiao-Feng Lin, Helena Schmidt, Brian Kunkle, Melanie L Dunstan, Maria Vronskaya, United Kingdom Brain Expression Consortium, Andrew D Johnson, Agustin Ruiz, Marie-Thérèse Bihoreau, Christiane Reitz, Florence Pasquier, Paul Hollingworth, Olivier Hanon, Annette L Fitzpatrick, Joseph D Buxbaum, Dominique Campion, Paul K Crane, Clinton Baldwin, Tim Becker, Vilmundur Gudnason, Carlos Cruchaga, David Craig, Najaf Amin, Claudine Berr, Oscar L Lopez, Philip L De Jager, Vincent Deramecourt, Janet A Johnston, Denis Evans, Simon Lovestone, Luc Letenneur, Isabel Hernández, David C Rubinsztein, Gudny Eiriksdottir, Kristel Sleegers, Alison M Goate, Nathalie Fiévet, Matthew J Huentelman, Michael Gill, Kristelle Brown, M Ilyas Kamboh, Lina Keller, Pascale Barberger-Gateau, Bernadette McGuinness, Eric B Larson, Amanda J Myers, Carole Dufouil, Stephen Todd, David Wallon, Seth Love, Ekaterina Rogaeva, John Gallacher, Peter St George-Hyslop, Jordi Clarimon, Alberto Lleo, Anthony Bayer, Debby W Tsuang, Lei Yu, Magda Tsolaki, Paola Bossù, Gianfranco Spalletta, Petra Proitsi, John Collinge, Sandro Sorbi, Florentino Sanchez Garcia, Nick C Fox, John Hardy, Maria Candida Deniz Naranjo, Paolo Bosco, Robert Clarke, Carol Brayne, Daniela Galimberti, Elio Scarpini, Ubaldo Bonuccelli, Michelangelo Mancuso, Gabriele Siciliano, Susanne Moebus, Patrizia Mecocci, Maria Del Zompo, Wolfgang Maier, Harald Hampel, Alberto Pilotto, Ana Frank-García, Francesco Panza, Vincenzo Solfrizzi, Paolo Caffarra, Benedetta Nacmias, William Perry, Manuel Mayhaus, Lars Lannfelt, Hakon Hakonarson, Sabrina Pichler, Minerva M Carrasquillo, Martin Ingelsson, Duane Beekly, Victoria Alvarez, Fanggeng Zou, Otto Valladares, Steven G Younkin, Eliecer Coto, Kara L Hamilton-Nelson, Wei Gu, Cristina Razquin, Pau Pastor, Ignacio Mateo, Michael J Owen, Kelley M Faber, Palmi V Jonsson, Onofre Combarros, Michael C O'Donovan, Laura B Cantwell, Hilkka Soininen, Deborah Blacker, Simon Mead, Thomas H Mosley, David A Bennett, Tamara B Harris, Laura Fratiglioni, Clive Holmes, Renee F A G de Bruijn, Peter Passmore, Thomas J Montine, Karolien Bettens, Jerome I Rotter, Alexis Brice, Kevin Morgan, Tatiana M Foroud, Walter A Kukull, Didier Hannequin, John F Powell, Michael A Nalls, Karen Ritchie, Kathryn L Lunetta, John S K Kauwe, Eric Boerwinkle, Matthias Riemenschneider, Mercè Boada, Mikko Hiltunen, Eden R Martin, Reinhold Schmidt, Dan Rujescu, Jean-François Dartigues, Richard Mayeux, Christophe Tzourio, Albert Hofman, Markus M Nöthen, Caroline Graff, Bruce M Psaty, Jonathan L Haines, Mark Lathrop, Margaret A Pericak-Vance, Lenore J Launer, Christine Van Broeckhoven, Lindsay A Farrer, Cornelia M van Duijn, Alfredo Ramirez, Sudha Seshadri, Gerard D Schellenberg, Philippe Amouyel, Julie Williams, Cardiovascular Health Study (CHS)
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e94661 (2014)
BACKGROUND:Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, usin
Externí odkaz:
https://doaj.org/article/7c3e3ea8c51e4bf49c84a3aa2f0bf34e
Autor:
Christiane Reitz, Giuseppe Tosto, Richard Mayeux, Jose A Luchsinger, NIA-LOAD/NCRAD Family Study Group, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50354 (2012)
BACKGROUND:Recent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODS:We used 1,877 Caucasian cases
Externí odkaz:
https://doaj.org/article/d7ffe3b8d3c04699bb2a64face9af7d7
Autor:
Christiane Reitz
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
Since 1992, the amyloid cascade hypothesis has played the prominent role in explaining the etiology and pathogenesis of Alzheimer's disease (AD). It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to t
Externí odkaz:
https://doaj.org/article/dce56e2c6640462c88b72a3455848c57
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Externí odkaz:
https://doaj.org/article/bdf5b281261747ae97c677f13d8d2659
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24588 (2011)
OBJECTIVE:We previously reported that genetic variants in SORCS1 increase the risk of AD, that over-expression of SorCS1 reduces γ-secretase activity and Aβ levels, and that SorCS1 suppression increases γ-secretase processing of APP and Aβ levels
Externí odkaz:
https://doaj.org/article/d732765d0fa542b1a01f7d9e81ab3291
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Externí odkaz:
https://doaj.org/article/5120a83e102d40d0b53fd71ed8b0db25
Publikováno v:
Nature Reviews Neurology. 19:261-277