Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Christiane R. Maroun"'
1
Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers
Autor: Elizabeth A. Tovar, Julie L. Boerner, Matthew R. Steensma, Erik S. Linklater, Carrie R. Graveel, Hasan Korkaya, Mary E. Winn, Curt J. Essenburg, Zachary Madaj, Christiane R. Maroun, Marianne Melnik, James G. Christensen, Lisa Turner
Publikováno v: Oncotarget
There is a vital need for improved therapeutic strategies that are effective in both primary and metastatic triple-negative breast cancer (TNBC). Current treatment options for TNBC patients are restricted to chemotherapy; however tyrosine kinases are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d0a4f8e04b7fd7eb8774a4e67beb3
https://doi.org/10.18632/oncotarget.12065
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2
The Met receptor tyrosine kinase: A key player in oncogenesis and drug resistance
Autor: Christiane R. Maroun, Tracey Rowlands
Publikováno v: Pharmacology & Therapeutics. 142:316-338
The Met receptor tyrosine kinase (RTK) is an attractive oncology therapeutic target. Met and its ligand, HGF, play a central role in signaling pathways that are exploited during the oncogenic process, including regulation of cell proliferation, invas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c66a6cbbfbf788d3dcdc567b8ae09
https://doi.org/10.1016/j.pharmthera.2013.12.014
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3
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
Autor: Sylvain Lefebvre, Silvana Leit, Alina Nicolescu, Marielle Fournel, Anthony Panetta, Jeffrey M. Besterman, Jubrail Rahil, Amal Wahhab, Anne-Marie Lemieux, Sukhdev Manku, Christiane R. Maroun, Yves Andre Chantigny, Theresa P. Yan, Robert Deziel, Zuomei Li, David Smil
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:688-692
In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/II
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c439dcbe0834654fc9fdc20ebf48fd5
https://doi.org/10.1016/j.bmcl.2008.12.045
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4
Distinct Recruitment and Function of Gab1 and Gab2 in Met Receptor-mediated Epithelial Morphogenesis
Autor: Lisa S. Lock, Morag Park, Monica A. Naujokas, Christiane R. Maroun
Publikováno v: Molecular Biology of the Cell. 13:2132-2146
The Gab family of docking proteins (Gab1 and Gab2) are phosphorylated in response to various cytokines and growth factors. Gab1 acts to diversify the signal downstream from the Met receptor tyrosine kinase through the recruitment of multiple signalin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0af9f3bc4c348046dc25d2bc405865
https://doi.org/10.1091/mbc.02-02-0031.
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5
Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44
Autor: Darren M. Kamikura, Christiane R. Maroun, Monica A. Naujokas, Morag Park, Hanane Khoury
Publikováno v: Molecular and Cellular Biology. 20:3482-3496
A Met-hepatocyte growth factor receptor oncoprotein, Tpr-Met, generated by chromosomal rearrangement, fuses a protein dimerization motif with the cytoplasmic domain of the Met receptor, producing a cytosolic, constitutively activated tyrosine kinase.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6397355a576409a0de67588b9d289e6a
https://doi.org/10.1128/.20.10.3482-3496.2000
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6
A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis
Autor: David K. Moscatello, Morag Park, Monica A. Naujokas, Marina Holgado-Madruga, Christiane R. Maroun, Albert J. Wong
Publikováno v: Journal of Biological Chemistry. 274:31719-31726
Stimulation of the hepatocyte growth factor receptor tyrosine kinase, Met, induces the inherent morphogenic program of epithelial cells. The multisubstrate binding protein Gab1 (Grb2-associated binder-1) is the major phosphorylated protein in epithel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c3a14a5ba24839c1168a8f6993cc50
https://doi.org/10.1074/jbc.274.44.31719
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7
Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356
Autor: Linh Nguyen, Albert J. Wong, Michel L. Tremblay, Christiane R. Maroun, Marina Holgado-Madruga, Morag Park, Alain Charest, Darren M. Kamikura, Elizabeth D. Fixman, Tanya M. Fournier
Publikováno v: Journal of Biological Chemistry. 272:20811-20819
Hepatocyte growth factor/scatter factor is a multifunctional factor that induces mitogenesis, motility, invasion, and branching tubulogenesis of several epithelial and endothelial cell lines in culture. The receptor for hepatocyte growth factor has b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa8ad61efa8abfeaeb2b291acda1c34
https://doi.org/10.1074/jbc.272.33.20811
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8
Distinct roles for CD4 and CD8 as co-receptors in T cell receptor signalling
Autor: Michael Julius, Christiane R. Maroun
Publikováno v: European Journal of Immunology. 24:959-966
We demonstrate that CD4 and CD8 modify signals induced through the T cell receptor for antigen (TCR alpha beta) in distinct fashions. Pretreatment of CD4+ lymph node T cells with CD4-specific monoclonal antibody results in a tenfold inhibition of DNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9f07d396fad682f1f04f988473c3b9
https://doi.org/10.1002/eji.1830240427
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9
Distinct involvement of CD45 in antigen receptor signalling in CD4+ and CD8+ primary T cells
Autor: Christiane R. Maroun, Michael Julius
Publikováno v: European Journal of Immunology. 24:967-973
We demonstrate that pretreatment of primary CD4+, but not CD8+ T cells with anti-CD45 inhibits activation signals induced through the T cell receptor for antigen (TCR alpha beta). Specifically, anti-TCR alpha beta-mediated tyrosine phosphorylation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16d2ab0231ac069c55ebaf8afc04792
https://doi.org/10.1002/eji.1830240428
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10
Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors
Autor: Jeffrey M. Besterman, Stephane Raeppel, Arkadii Vaisburg, Hannah Nguyen, Frédéric Gaudette, James Wang, Normand Beaulieu, Christiane R. Maroun
Publikováno v: International Journal of Medicinal Chemistry
International Journal of Medicinal Chemistry, Vol 2012 (2012)
A novel series of N-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8a3ea01d014cd6d3464ff2a9a47008
https://pubmed.ncbi.nlm.nih.gov/25954527
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