Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial

Autor: Christiane Mosbech, Finn Rønholt, Charlotte Suppli Ulrik, Mia Moberg, Helle Frost Andreassen, Therese S. Lapperre, Rasmus Rude Laub, Jørgen Vestbo, Julie Janner, Aras K.M. Ali, Charlotte Sandau Bech, Pradeesh Sivapalan, Eva Brøndum, Tine Peick Sonne, Niels Seersholm, Freja Stæhr Holm, Karin Armbruster, Jon Torgny Wilcke, Praleene Sivapalan, Josefin Eklöf, Jens-Ulrik Stæhr Jensen

Publikováno v: Sivapalan, P, Lapperre, T S, Janner, J, Laub, R R, Moberg, M, Bech, C S, Eklöf, J, Holm, F S, Armbruster, K, Sivapalan, P, Mosbech, C, Ali, A K M, Seersholm, N, Wilcke, J T, Brøndum, E, Sonne, T P, Rønholt, F, Andreassen, H F, Ulrik, C S, Vestbo, J & Jensen, J S 2019, ' Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial ', The Lancet Respiratory Medicine, vol. 7, no. 8, pp. 699-709 . https://doi.org/10.1016/S2213-2600(19)30176-6
Sivapalan, P, Lapperre, T S, Janner, J, Laub, R R, Moberg, M, Bech, C S, Eklöf, J, Holm, F S, Armbruster, K, Sivapalan, P, Mosbech, C, Ali, A K M, Seersholm, N, Wilcke, J T, Brøndum, E, Sonne, T P, Rønholt, F, Andreassen, H F, Ulrik, C S, Vestbo, J & Jensen, J-U S 2019, ' Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP) : a multicentre, randomised, controlled, open-label, non-inferiority trial ', The Lancet Respiratory Medicine, vol. 7, no. 8, pp. 699-709 . https://doi.org/10.1016/S2213-2600(19)30176-6
The lancet respiratory medicine

BACKGROUND: Treatment with systemic corticosteroids in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) is associated with debilitating adverse effects. Therefore, strategies to reduce systemic corticosteroid exposure

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https://linkinghub.elsevier.com/retrieve/pii/S2213260019301766