Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Christiane Kleuss"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop Immun
Externí odkaz:
https://doaj.org/article/cd362b38f0e243bcafc875010750b3bb
Autor:
Anne Endmann, Katharina Klünder, Kerstin Kapp, Oliver Riede, Detlef Oswald, Eduard G Talman, Matthias Schroff, Christiane Kleuss, Marcel H J Ruiters, Christiane Juhls
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101715 (2014)
Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains
Externí odkaz:
https://doaj.org/article/236f808e02ba4a9888d1cf0f72287c2d
Autor:
Lisa Schneider, Jacqueline Schneider, Nadine Gollinge, Stefanie Jänsch, Burghardt Wittig, Kerstin Kapp, Christiane Kleuss, Matthias Schroff
Publikováno v:
Immunity, Inflammation and Disease
Introduction DNA‐based TLR9 agonists are potent activators of the immune system. ProMune® and dSLIM® belong to different families of TLR9 agonists and both have been established as cancer immunotherapeutics in clinical proof‐of‐concept studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8614815bd5631d96f0fd29a71648896
https://doi.org/10.1002/iid3.126
https://doi.org/10.1002/iid3.126
Autor:
Detlef Oswald, Christiane Kleuss, Christiane Juhls, Matthias Schroff, Anne Endmann, Marcel H. J. Ruiters, Roelien E. Vos, Eduard G. Talman, Oliver Riede
Publikováno v:
Vaccine, 32(27), 3460-3467. ELSEVIER SCI LTD
We have previously shown that the combination of MIDGE-Th1 DNA vectors with the cationic lipid SAINT-18 increases the immune response to the encoded antigen in mice. Here, we report on experiments to further optimize and characterize this approach. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13917cb64fc566bc694436580c4b3e7c
https://doi.org/10.1016/j.vaccine.2014.03.048
https://doi.org/10.1016/j.vaccine.2014.03.048
Autor:
Victor Wray, Peter Henklein, Oliver P. Ernst, Martin Heck, Christiane Kleuss, Klaus Peter Hofmann, Rolf Herrmann
Publikováno v:
Vision Research. 46(27):4582-4593
In the early steps of visual signal transduction, light-activated rhodopsin (R*) catalyzes GDP/GTP exchange in the heterotrimeric G protein (Galphabetagamma) transducin. We recently reported that the catalytic interaction involves two sequential step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d57c4d7cf8f6a56a13affea71dfd13
Publikováno v:
Journal of Biological Chemistry. 281:288-294
The Gbetagamma complex of heterotrimeric G proteins is the most outstanding example for the divergent regulation of mammalian adenylyl cyclases. The heterodimeric Gbetagamma complex inhibits some isoforms, e.g. ACI, and stimulates the isoforms ACII,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440a4433792b1f830fb96fbd367d568c
https://doi.org/10.1074/jbc.m511045200
https://doi.org/10.1074/jbc.m511045200
Autor:
Peter Henklein, Petra Henklein, Oliver P. Ernst, Christiane Kleuss, Rolf Herrmann, Klaus Peter Hofmann, Martin Heck
Publikováno v:
Journal of Biological Chemistry. 279:24283-24290
Guanine nucleotide exchange in heterotrimeric G proteins catalyzed by G protein-coupled receptors (GPCRs) is a key event in many physiological processes. The crystal structures of the GPCR rhodopsin and two G proteins as well as binding sites on both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444e0eb31a83ff81d1db63051efe552e
https://doi.org/10.1074/jbc.m311166200
https://doi.org/10.1074/jbc.m311166200
Autor:
Howard A. Rockman, Juliane Bernotat, Lan Mao, Walter J. Koch, Sven T. Pleger, Hugo A. Katus, Christiane Kleuss, Andrew Remppis, Patricia Ruiz, Peter Karczewski, Philipp Ehlermann, Eva Löffler, Patrick Most, Sandra J. Duncan, Joerg Heierhorst, Henning Witt
Publikováno v:
Journal of Biological Chemistry. 278:33809-33817
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile properties. To study the physiological consequences of S100A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647caf6970b30ef1ba9fcc59966e3d4e
https://doi.org/10.1074/jbc.m301788200
https://doi.org/10.1074/jbc.m301788200
Autor:
Christiane Kleuss, Kerstin Kapp, Eduard G. Talman, Anne Endmann, Marcel H. J. Ruiters, Detlef Oswald, Oliver Riede, Matthias Schroff, Katharina Klünder, Christiane Juhls
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101715 (2014)
PLoS ONE
PLoS ONE, 9(7):e101715. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, 9(7):e101715. PUBLIC LIBRARY SCIENCE
Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc7e14352b294c788c9a2d029cc255b
https://research.rug.nl/en/publications/37e9d410-cdf7-4246-9c58-b09615a09a08
https://research.rug.nl/en/publications/37e9d410-cdf7-4246-9c58-b09615a09a08
Publikováno v:
Biochemistry. 40:10853-10858
Mammalian particulate adenylyl cyclases contain two transmembrane regions (M(1) and M(2)) and two cytosolic domains (C(1) and C(2)) forming the catalytic core. The cytosolic domains are subdivided into a highly conserved region (part a) and a region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d7f6ebd54da17373ee03db1e383871
https://doi.org/10.1021/bi011176w
https://doi.org/10.1021/bi011176w