Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Christiane Hertz-Fowler"'
Autor:
Oscar A. Nyangiri, Harry Noyes, Julius Mulindwa, Hamidou Ilboudo, Justin Windingoudi Kabore, Bernardin Ahouty, Mathurin Koffi, Olivier Fataki Asina, Dieudonne Mumba, Elvis Ofon, Gustave Simo, Magambo Phillip Kimuda, John Enyaru, Vincent Pius Alibu, Kelita Kamoto, John Chisi, Martin Simuunza, Mamadou Camara, Issa Sidibe, Annette MacLeod, Bruno Bucheton, Neil Hall, Christiane Hertz-Fowler, Enock Matovu, for the TrypanoGEN Research Group, as members of The H3Africa Consortium
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Copy number variation is an important class of genomic variation that has been reported in 75% of the human genome. However, it is underreported in African populations. Copy number variants (CNVs) could have important impacts on d
Externí odkaz:
https://doaj.org/article/0c8da21a0aef47b6996844a037137818
Autor:
Sam Haldenby, Christina Bronowski, Charlotte Nelson, John Kenny, Carmen Martinez-Rodriguez, Roy Chaudhuri, Nicola J Williams, Ken Forbes, Norval J Strachan, Jane Pulman, Ian N Winstanley, Caroline E Corless, Tom J Humphrey, Frederick J Bolton, Sarah J O'Brien, Neil Hall, Christiane Hertz-Fowler, Craig Winstanley
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227535 (2020)
BackgroundCampylobacter jejuni is the most common bacterial cause of human infectious intestinal disease.MethodsWe genome sequenced 601 human C. jejuni isolates, obtained from two large prospective studies of infectious intestinal disease (IID1 [isol
Externí odkaz:
https://doaj.org/article/72fd2b751da34c56b4103af86ab2d938
Autor:
Rosalinda D’Amore, James Johnson, Sam Haldenby, Neil Hall, Margaret Hughes, Ryan Joynson, John G. Kenny, Nicola Patron, Christiane Hertz-Fowler, Anthony Hall
Publikováno v:
BioTechniques, Vol 63, Iss 1, Pp 13-20 (2017)
Current DNA assembly methods are prone to sequence errors, requiring rigorous quality control (QC) to identify incorrect assemblies or synthesized constructs. Such errors can lead to misinterpretation of phenotypes. Because of this intrinsic problem,
Externí odkaz:
https://doaj.org/article/32437ff61ade49ff976eb88a8930ad19
Autor:
Siddharth Jayaraman, Claire Harris, Edith Paxton, Anne-Marie Donachie, Heli Vaikkinen, Richard McCulloch, James P J Hall, John Kenny, Luca Lenzi, Christiane Hertz-Fowler, Christina Cobbold, Richard Reeve, Tom Michoel, Liam J Morrison
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 4, p e0007262 (2019)
Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a la
Externí odkaz:
https://doaj.org/article/e97f4a4757b749a9a3f0afa32c365e78
Autor:
Elvis Ofon, Harry Noyes, Vincent Ebo'o Eyanga, Flobert Njiokou, Mathurin Koffi, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Enock Matovu, Gustave Simo, TrypanoGEN Research Group, as members of The H3Africa Consortium
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007283 (2019)
BACKGROUND:Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence
Externí odkaz:
https://doaj.org/article/1961301c9c664337929cb2cba85978ed
Autor:
Sophie Thornton, Sarah E. Coupland, Lisa Olohan, Julie S. Sibbring, John G. Kenny, Christiane Hertz-Fowler, Xuan Liu, Sam Haldenby, Heinrich Heimann, Rumana Hussain, Natalie Kipling, Azzam Taktak, Helen Kalirai
Publikováno v:
Cancers, Vol 12, Iss 4, p 1039 (2020)
Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, SF3B1 and EIF1AX, most being linked to metastatic-risk. To gain further ins
Externí odkaz:
https://doaj.org/article/debe3ef14aaf4a2a945de9cd20f01320
Autor:
Magambo Phillip Kimuda, Harry Noyes, Julius Mulindwa, John Enyaru, Vincent Pius Alibu, Issa Sidibe, Dieuodonne Mumba Ngoyi, Christiane Hertz-Fowler, Annette MacLeod, Özlem Tastan Bishop, Enock Matovu, TrypanoGEN Research Group as members of The H3Africa Consortium
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006300 (2018)
Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes,
Externí odkaz:
https://doaj.org/article/6ccfc72c1d7042829c20058fcfd2451e
Autor:
Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo, Gustave Simo, Enock Matovu, Julius Mulindwa, Christiane Hertz-Fowler, Bruno Bucheton, Issa Sidibé, Vincent Jamonneau, Annette MacLeod, Harry Noyes, Simon-Pierre N'Guetta, TrypanoGEN Research Group as members of The H3Africa Consortium
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005992 (2017)
Human African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. Long regarded as an invariably fatal disease, there is increasing evidence that infection by T. b. gambiense can result in a wide range of clinical outcomes, in
Externí odkaz:
https://doaj.org/article/be22c9ac55a94b42b277d1aaa4ae23e9
Autor:
Elvis Ofon, Harry Noyes, Julius Mulindwa, Hamidou Ilboudo, Martin Simuunza, Vincent Ebo'o, Flobert Njiokou, Mathurin Koffi, Bruno Bucheton, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Gustave Simo, TrypanoGEN Research Group, as members of The H3Africa Consortium
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005979 (2017)
Human African Trypanosomiasis (HAT) is a neglected disease targeted for elimination as a public health problem by 2020. Elimination requires a better understanding of the epidemiology and clinical evolution of HAT. In addition to the classical clinic
Externí odkaz:
https://doaj.org/article/cbf6e1770c9346a7a66a396abf34ee2b
Autor:
Justin Windingoudi Kaboré, Hamidou Ilboudo, Harry Noyes, Oumou Camara, Jacques Kaboré, Mamadou Camara, Mathurin Koffi, Veerle Lejon, Vincent Jamonneau, Annette MacLeod, Christiane Hertz-Fowler, Adrien Marie Gaston Belem, Enock Matovu, Bruno Bucheton, Issa Sidibe, TrypanoGEN Research Group as members of The H3Africa Consortium
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005833 (2017)
Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals
Externí odkaz:
https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7