Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christiane Happe"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Thymopoiesis strictly depends on the function of the Foxn1 transcription factor that is expressed in the thymic epithelium. During embryonic development, initial expression of the Foxn1 gene is induced in the pharyngeal endoderm by mesenchym
Externí odkaz:
https://doaj.org/article/026580411d4f43ba82d7e49d1ec1930a
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain una
Externí odkaz:
https://doaj.org/article/77d9ffad1f2241eab4bd1f1a5200e4ce
Autor:
Jeremy B. Swann, Annelies Weyn, Daisuke Nagakubo, Conrad C. Bleul, Atsushi Toyoda, Christiane Happe, Nikolai Netuschil, Isabell Hess, Annette Haas-Assenbaum, Yoshihito Taniguchi, Michael Schorpp, Thomas Boehm
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1184-1197 (2014)
The thymus is a lymphoid organ unique to vertebrates, and it provides a unique microenvironment that facilitates the differentiation of immature hematopoietic precursors into mature T cells. We subjected the evolutionary trajectory of the thymic micr
Externí odkaz:
https://doaj.org/article/ca82771736a049f9915b6f7d602cd395
Autor:
Omar L. Francone, Brian Y. Ishida, Margarita de la Llera-Moya, Lori Royer, Christiane Happe, Jian Zhu, Robert J. Chalkey, Peter Schaefer, Cheryl Cox, Al Burlingame, John P. Kane, George H. Rothblat
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1974-1983 (2011)
Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations that impact risk factors associated with the development of this disease continues. Multiple genetic association studies demonstrate that procoll
Externí odkaz:
https://doaj.org/article/41e1133ed2ab4ba59e70694a3664f103
Autor:
Anja Nusser, null Sagar, Jeremy B. Swann, Brigitte Krauth, Dagmar Diekhoff, Lesly Calderon, Christiane Happe, Dominic Grün, Thomas Boehm
Publikováno v:
Nature
T cell development in the thymus is essential for cellular immunity and depends on the organotypic thymic epithelial microenvironment. In comparison with other organs, the size and cellular composition of the thymus are unusually dynamic, as exemplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5617748dda5d0a422bcb38bcf6347b
https://hdl.handle.net/21.11116/0000-000A-8C1E-821.11116/0000-000A-8C1C-A
https://hdl.handle.net/21.11116/0000-000A-8C1E-821.11116/0000-000A-8C1C-A
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Thymopoiesis strictly depends on the function of the Foxn1 transcription factor that is expressed in the thymic epithelium. During embryonic development, initial expression of the Foxn1 gene is induced in the pharyngeal endoderm by mesenchyme-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c940d3842a041ad15490a5fc45bd8150
https://doaj.org/article/026580411d4f43ba82d7e49d1ec1930a
https://doaj.org/article/026580411d4f43ba82d7e49d1ec1930a
Autor:
Brigitte Krauth, Sergiy V. Avilov, Anja Nusser, Benoît Kanzler, Daisuke Nagakubo, Thomas Boehm, Mayumi Hirakawa, Jeremy B. Swann, Christiane Happe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
The numbers of thymic epithelial cells (TECs) and thymocytes steadily increase during embryogenesis. To examine this dynamic, we generated several TEC-specific transgenic mouse lines, which express fluorescent proteins in the nucleus, the cytosol and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e4f58830d07d0a40fa133c131d7ae5
http://europepmc.org/articles/PMC6056470
http://europepmc.org/articles/PMC6056470
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b291ba3186fbc27dc6f30651f46dd8
https://doi.org/10.1038/s41598-017-00842-0
https://doi.org/10.1038/s41598-017-00842-0
Autor:
Alma L. Burlingame, Cheryl J. Cox, John P. Kane, Lori Royer, Peter M. Schaefer, George H. Rothblat, Margarita de la Llera-Moya, Brian Y. Ishida, Robert J. Chalkey, Jian Zhu, Omar L. Francone, Christiane Happe
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1974-1983 (2011)
Given the increased prevalence of cardiovascular disease in the world, the search for genetic variations that impact risk factors associated with the development of this disease continues. Multiple genetic association studies demonstrate that procoll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18c482ffcb552604fab4979cce8729b
https://doi.org/10.1194/jlr.m016527
https://doi.org/10.1194/jlr.m016527
Autor:
Nikolai Netuschil, Annette Haas-Assenbaum, Annelies Weyn, Michael Schorpp, Yoshihito Taniguchi, Thomas Boehm, Daisuke Nagakubo, Conrad C. Bleul, Atsushi Toyoda, Isabell Hess, Christiane Happe, Jeremy B. Swann
Publikováno v:
Cell Reports
Cell Reports, Vol 8, Iss 4, Pp 1184-1197 (2014)
Cell Reports, Vol 8, Iss 4, Pp 1184-1197 (2014)
SummaryThe thymus is a lymphoid organ unique to vertebrates, and it provides a unique microenvironment that facilitates the differentiation of immature hematopoietic precursors into mature T cells. We subjected the evolutionary trajectory of the thym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a5050652075a673c253e6b8a4a4da1
https://pubmed.ncbi.nlm.nih.gov/25148021
https://pubmed.ncbi.nlm.nih.gov/25148021