Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christiane Hanselmann"'
Autor:
Hugo A. Katus, Johanne Gantenberg, Derk Frank, Robert Frauen, László Füzesi, Christian Kuhn, Rainer Will, Christiane Hanselmann, Norbert Frey
Publikováno v:
Journal of Molecular and Cellular Cardiology. 49:673-682
To identify new mediators of cardiac hypertrophy, we performed a genome-wide mRNA screen of stretched neonatal rat cardiomyocytes (NRCMs). In addition to known members of the hypertrophic gene program, we found the novel sarcomeric Z-disc LIM protein
Autor:
Hugo A. Katus, Derk Frank, Benedikt Brors, Christiane Hanselmann, Christian Kuhn, Norbert Frey, Mark Lüdde
Publikováno v:
Hypertension. 51:309-318
Biomechanical stress ie, attributable to pressure overload, leads to cardiac hypertrophy and may ultimately cause heart failure. Yet, it is still unclear how mechanical stress is sensed and transduced on the molecular level. To systematically elucida
Autor:
Hugo A. Katus, Christian Kuhn, Rainer Will, Norbert Frey, Doris Gehring, Martin van Eickels, Derk Frank, Stefanie Lippl, Christiane Hanselmann
Publikováno v:
Circulation. 116:2587-2596
Background— We have previously shown that deficiency for the z-disc protein calsarcin-1 (CS1) sensitizes the heart to calcineurin signaling and to stimuli of pathological hypertrophy. In the present study we asked whether overexpression of CS1 migh
Autor:
Derk Frank, Robert Frauen, Christiane Hanselmann, Christian Kuhn, Rainer Will, Hugo A Katus, Norbert Frey
Publikováno v:
Circulation. 118
In order to identify new molecular mediators of cardiomyocyte hypertrophy, we performed a genome wide mRNA microarray screen of biomechanically stretched neonatal rat cardiomyocytes (NRCM). We found the novel sarcomeric LIM protein Dyxin/Lmcd1 being
Publikováno v:
Circulation. 116
Sustained cardiac hypertrophy may lead to heart failure and sudden death. While significant progress has been made in elucidating the underlying molecular mechanisms, it is believed that several molecules that modulate cardiomyocyte growth remain elu