Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Christiane Frahm"'
Autor:
Maja Olecka, Alena van Bömmel, Lena Best, Madlen Haase, Silke Foerste, Konstantin Riege, Thomas Dost, Stefano Flor, Otto W. Witte, Sören Franzenburg, Marco Groth, Björn von Eyss, Christoph Kaleta, Christiane Frahm, Steve Hoffmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although DNA methylation data yields highly accurate age predictors, little is known about the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the gap, we investigate the methylation trajectories of male mouse
Externí odkaz:
https://doaj.org/article/1b1921c741ae4512a8ba29546dcdf82a
Autor:
Simon J. Schrenk, Stefan Brodoehl, Stefano Flor, Christiane Frahm, Christian Gaser, Rami Abou Hamdan, Marco Herbsleb, Christoph Kaleta, Fabian Kattlun, Hans-Josef Müller, Christian Puta, Monique Radscheidt, Adriana L. Ruiz-Rizzo, Tannaz Saraei, André Scherag, Thomas Steidten, Otto W. Witte, Kathrin Finke
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionBy 2050, the worldwide percentage of people 65 years and older is assumed to have doubled compared to current numbers. Therefore, finding ways of promoting healthy (cognitive) aging is crucial. Physical activity is considered an effective
Externí odkaz:
https://doaj.org/article/a2289b8f695e44d699a90768e08f4a98
Autor:
Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Monika S. Brill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies
Externí odkaz:
https://doaj.org/article/ec46b342acf04066b968bee81cb16163
Autor:
Yuanyuan Ji, Dennis Koch, Jule González Delgado, Madlen Günther, Otto W Witte, Michael M Kessels, Christiane Frahm, Britta Qualmann
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001399 (2021)
Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic arborization of penumbral neurons. These defects were subsequently repaired
Externí odkaz:
https://doaj.org/article/b5a306c1cf004a1aab234693a6cf7d1e
Autor:
Silvio Schmidt, Madlen Haase, Lena Best, Marco Groth, Julia Lindner, Otto W. Witte, Christoph Kaleta, Christiane Frahm
Publikováno v:
Cells, Vol 11, Iss 23, p 3864 (2022)
Cognitive decline is one of the greatest health threats of old age and the maintenance of optimal brain function across a lifespan remains a big challenge. The hippocampus is considered particularly vulnerable but there is cross-species consensus tha
Externí odkaz:
https://doaj.org/article/abdc71c2b130471d8afa1117a2f3eb67
Autor:
Anja Baumann, Angélica Hernández-Arriaga, Annette Brandt, Victor Sánchez, Anika Nier, Finn Jung, Richard Kehm, Annika Höhn, Tilman Grune, Christiane Frahm, Otto Wilhelm Witte, Amélia Camarinha-Silva, Ina Bergheim
Publikováno v:
International Journal of Medical Microbiology, Vol 311, Iss 4, Pp 151500- (2021)
Background: The number of people above the age of 60 years is raising world-wide being associated with an increase in the prevalence of aging-associated impairments and even diseases. Recent studies suggest that aging is associated with alterations i
Externí odkaz:
https://doaj.org/article/f4309e165bbf4a7e8ea119ea4a2654f8
Autor:
Marie-Luise Ederer, Madlen Günther, Lena Best, Julia Lindner, Christoph Kaleta, Otto W. Witte, Rowena Simon, Christiane Frahm
Publikováno v:
Cells, Vol 11, Iss 3, p 566 (2022)
Inflammation is considered a possible cause of cognitive decline during aging. This study investigates the influence of physical activity and social isolation in old mice on their cognitive functions and inflammation. The Barnes maze task was perform
Externí odkaz:
https://doaj.org/article/911f8b7319284555b71545057d25632a
Autor:
Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Jule Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W. Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degener
Externí odkaz:
https://doaj.org/article/463f3bfceed14b74b71020ee1edcf215
Autor:
Nadine Jaenisch, Anke Popp, Madlen Guenther, Juliane Schnabel, Otto W. Witte, Christiane Frahm
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 237-244 (2014)
Following cerebral injuries such as stroke, a structural and functional reorganization of the impaired tissue occurs, which is often accompanied by a re-expression of developmental genes. During brain development, embryonic splice variants of the GAB
Externí odkaz:
https://doaj.org/article/4efa2dad9edd40b1a8e5350776ef7034
Autor:
Angélica Hernández-Arriaga, Anja Baumann, Otto W. Witte, Christiane Frahm, Ina Bergheim, Amélia Camarinha-Silva
Publikováno v:
Microorganisms, Vol 7, Iss 9, p 283 (2019)
The mouth is an important niche for bacterial colonization. Previous research used mouth microbiota to predict diseases like colon cancer and inflammatory bowel disease (IBD). It is still unclear how the sampling methodology influences microbial char
Externí odkaz:
https://doaj.org/article/98c875aa8c1d4c60ba3172994a8159ae