Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Christiane E. Wobus"'
Autor:
Elena N. Atochina-Vasserman, Lisa C. Lindesmith, Carmen Mirabelli, Nathan A. Ona, Erin K. Reagan, Paul D. Brewer-Jensen, Xiomara Mercado-Lopez, Hamna Shahnawaz, Jaclynn A. Meshanni, Ishana Baboo, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Barbara L. Mui, Ying K. Tam, Christiane E. Wobus, Ralph S. Baric, Drew Weissman
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Nucleoside-modified mRNA-LNP vaccines have revolutionized vaccine development against infectious pathogens due to their ability to elicit potent humoral and cellular immune responses. In this article, we present the results of the first noro
Externí odkaz:
https://doaj.org/article/edc4158664a44a999625dbd69f0184a0
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Autor:
Alexa N. Roth, Emily W. Helm, Carmen Mirabelli, Erin Kirsche, Jonathan C. Smith, Laura B. Eurell, Sourish Ghosh, Nihal Altan-Bonnet, Christiane E. Wobus, Stephanie M. Karst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising
Externí odkaz:
https://doaj.org/article/9a6932ec89e94268872ca25929c2bda7
Autor:
Anna-Lisa E. Lawrence, Basel H. Abuaita, Ryan P. Berger, David R. Hill, Sha Huang, Veda K. Yadagiri, Brooke Bons, Courtney Fields, Christiane E. Wobus, Jason R. Spence, Vincent B. Young, Mary X. O’Riordan
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Salmonella entericaS
Externí odkaz:
https://doaj.org/article/03f9d926e18e4f8f85620941b17d954e
Autor:
Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet co
Externí odkaz:
https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1
Autor:
Jesse W. Wotring, Sean M. McCarty, Khadija Shafiq, Charles J. Zhang, Theophilus Nguyen, Sophia R. Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C. Clasby, Christiane E. Wobus, Matthew J. O’Meara, Jonathan Z. Sexton
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1284 (2022)
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro, generating
Externí odkaz:
https://doaj.org/article/487964f7eb2346369351c8a5aaae5f65
Publikováno v:
Molecules, Vol 27, Iss 12, p 3815 (2022)
The severity of the COVID-19 pandemic and the pace of its global spread have motivated researchers to opt for repurposing existing drugs against SARS-CoV-2 rather than discover or develop novel ones. For reasons of speed, throughput, and cost-effecti
Externí odkaz:
https://doaj.org/article/c9931350cf1f44f294c48c3463505e70
Autor:
Michael B. Sherman, Alexis N. Williams, Hong Q. Smith, B. Montgomery Pettitt, Christiane E. Wobus, Thomas J. Smith
Publikováno v:
Viruses, Vol 13, Iss 11, p 2162 (2021)
Noroviruses are responsible for almost a fifth of all cases of gastroenteritis worldwide. The calicivirus capsid is composed of 180 copies of VP1 with a molecular weight of ~58 kDa. This coat protein is divided into the N-terminus (N), the shell (S)
Externí odkaz:
https://doaj.org/article/05de2b4e581245df82b16756955a039b
Publikováno v:
Viruses, Vol 13, Iss 6, p 1059 (2021)
Acute gastroenteritis (AGE) has a significant disease burden on society. Noroviruses, rotaviruses, and astroviruses are important viral causes of AGE but are relatively understudied enteric pathogens. Recent developments in novel biomimetic human mod
Externí odkaz:
https://doaj.org/article/f4584369b0494c01a6d83c1ea3fa5f65
Autor:
Karla D. Passalacqua, Jia Lu, Ian Goodfellow, Abimbola O. Kolawole, Jacob R. Arche, Robert J. Maddox, Kelly E. Carnahan, Mary X. D. O’Riordan, Christiane E. Wobus
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated by some viruses to favor infection. Howe
Externí odkaz:
https://doaj.org/article/816f72c400f1417ea2ea221faebff586