Výsledky vyhledávání - "Christiane Dresch"

Akademický článek

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization.

Autor: Daniela Giordano, Kevin E Draves, Lucy B Young, Kelsey Roe, Marianne A Bryan, Christiane Dresch, Justin M Richner, Michael S Diamond, Michael Gale, Edward A Clark

Publikováno v: PLoS Pathogens, Vol 13, Iss 11, p e1006743 (2017)

B cell activating factor receptor (BAFFR)-/- mice have a profound reduction in mature B cells, but unlike μMT mice, they have normal numbers of newly formed, immature B cells. Using a West Nile virus (WNV) challenge model that requires antibodies (A

Externí odkaz: https://doaj.org/article/85cf9e3d148944219c2170442d4a53f5

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HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice

Autor: Mabel Berois, Laura Emilia Esteban, Juan Carlos Abdusetir Cerfoglio, Alejandro A. Castello, Graciela Glikmann, Monika Hilbe, Alberto L. Epstein, Michael Seyffert, Nora Mattion, Christiane Dresch, Elisabeth M. Schraner, Juan Arbiza, Mathias Ackermann, Cornel Fraefel, Andrea S. Laimbacher, Alejandra D'Antuono, Marcelo Horacio Argüelles

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy
Molecular Therapy
Molecular Therapy, Cell Press, 2012, 20 (9), pp.1810-20. ⟨10.1038/mt.2012.108⟩

Virus-like particles (VLPs) are promising vaccine candidates because they represent viral antigens in the authentic conformation of the virion and are therefore readily recognized by the immune system. As VLPs do not contain genetic material they are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6886e9bb9fe753ae20f8e4e5fb31d8dc
https://www.ncbi.nlm.nih.gov/pubmed/22713696

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Analysis of two T-cell receptor BV gene segment polymorphisms in caucasoid Brazilian patients with rheumatoid arthritis

Autor: João Carlos Tavares Brenol, José Artur Bogo Chies, Ricardo Machado Xavier, Nance Beyer Nardi, Christiane Dresch

Publikováno v: Immunology Letters. 90:77-80

Considering the role of T-lymphocytes in rheumatoid arthritis (RA) and a possible involvement of the TCR in the pathology of this disease we analyzed allelic and genotypic frequencies of variants of two TCRBV gene segments (TCRBV3S1 and TCRBV18) in R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680daec032562e21c8e5994968b9ee26
https://doi.org/10.1016/s0165-2478(03)00174-3

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TCRBV3S1 and TCRBV18 gene segment polymorphisms in Brazilian Caucasoid and Black populations

Autor: José Artur Bogo Chies, Nance Beyer Nardi, Christiane Dresch

Publikováno v: European Journal of Immunogenetics. 29:11-15

The T-cell receptor (TCR) repertoire plays an important role in shaping specific immune responses. Genetic polymorphisms at the TCR locus, in both constant and variable regions, seem to represent an important mechanism for generating inter-individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc79a6fc55aefc7febe8832488157bdf
https://doi.org/10.1046/j.1365-2370.2002.00267.x

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Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells

Autor: Mathias Ackermann, Bernd Vogt, B de Andrade Pereira, Cornel Fraefel, S Chaudhary, Christiane Dresch, Rebecca Vogel

Publikováno v: Gene therapy. 22(5)

We have recently shown that targeted expression of myelin oligodendrocyte glycoprotein (MOG) to dendritic cells with self-inactivating-lentivirus vectors induces antigen-specific tolerance in naive antigen-specific CD4+ T cells and protects mice from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa923d8bdd9140659b618a2cd345780c
https://pubmed.ncbi.nlm.nih.gov/25739989

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Controlling immune responses by targeting antigens to dendritic cell subsets and B cells

Autor: Christiane Dresch, Craig P. Chappell, Natalia V. Giltiay, Edward A. Clark

Delivering antigens in vivo by coupling them to mAbs specific for unique receptors on antigen-presenting cells (APCs) is a promising approach for modulating immune responses. Antigen delivery to receptors found on myeloid dendritic cell (DC) subsets,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29406270f86372c9196c20380a4424f4
https://europepmc.org/articles/PMC3904668/

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Mature B cell deficient-BAFFR−/− mice can be protected from a lethal WNV-Tx (WNV) infection by vaccination with an anti-CD180 (RP105) antibody - WNVEnv protein conjugate (αCD180-WNVE)

Autor: Daniela Giordano, Kevin E Draves, Marianne A Bryan, Christiane Dresch, Lucy B Young, Kelsey Roe, Justin M Richner, Michael S Diamond, Michael J Gale, Edward A Clark

Publikováno v: The Journal of Immunology. 196:146.13-146.13

BAFFR−/− mice are a model of humoral immunodeficiency since they lack mature B cells. We found that in contrast to WT mice BAFFR−/− mice were highly susceptible to WNV. BAFFR−/− mice infected with 100pfu WNV succumbed to infection between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fc4e95de65ff0d395fb45dde5d802dd
https://doi.org/10.4049/jimmunol.196.supp.146.13

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Development of antigen cross-presentation capacity in dendritic cells

Autor: Yann Leverrier, Christiane Dresch, Jacqueline Marvel, Ken Shortman

Publikováno v: Trends in immunology. 33(8)

Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd49f54e0d8f7135ea671ed25a090b6
https://pubmed.ncbi.nlm.nih.gov/22677187

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Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection

Autor: Matthew D. Weitzman, Michael Seyffert, Nelly Jolinon, Cornel Fraefel, Christiane Dresch, Mathias Ackermann, Anna Paula de Oliveira, Regina Strasser, Rebecca Vogel, Daniel L. Glauser, Anna Salvetti

Publikováno v: Journal of virology. 86(1)

Adeno-associated virus type 2 (AAV2) is a human parvovirus that relies on a helper virus for efficient replication. Herpes simplex virus 1 (HSV-1) supplies helper functions and changes the environment of the cell to promote AAV2 replication. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7158ec27685fecf267d5ee53c33dda4
https://pubmed.ncbi.nlm.nih.gov/22013059

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Thymic but not splenic CD8⁺ DCs can efficiently cross-prime T cells in the absence of licensing factors

Autor: Bernd Vogt, Cornel Fraefel, Ken Shortman, Mathias Ackermann, Christiane Dresch, Bruna de Andrade Pereira

Publikováno v: European journal of immunology. 41(9)

Cross-presentation is an important mechanism to elicit both immune defenses and tolerance. Although only a few DC subsets possess the machinery required for cross-presentation, little is known about differences in cross-presenting capabilities of DCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bdc5231aae9974661e8f3fc9f6b6a7
https://pubmed.ncbi.nlm.nih.gov/21748731

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