Zobrazeno 1 - 10
of 731
pro vyhledávání: '"Christiane D"'
Autor:
Robert A. Eder, Maaike van den Boomen, Salva R. Yurista, Yaiel G. Rodriguez-Aviles, Mohammad Rashedul Islam, Yin-Ching Iris Chen, Lena Trager, Jaume Coll-Font, Leo Cheng, Haobo Li, Anthony Rosenzweig, Christiane D. Wrann, Christopher T. Nguyen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart’s microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes.
Externí odkaz:
https://doaj.org/article/9279bb19fa174069a6527d0d10721a90
Autor:
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic re
Externí odkaz:
https://doaj.org/article/9edc09523ab84bf68816a3ad42d52779
Autor:
Dariush Skowronek, Robin A. Pilz, Loisa Bonde, Ole J. Schamuhn, Janne L. Feldmann, Sabine Hoffjan, Christiane D. Much, Ute Felbor, Matthias Rath
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15639 (2022)
Deletions in the CCM1, CCM2, and CCM3 genes are a common cause of familial cerebral cavernous malformations (CCMs). In current molecular genetic laboratories, targeted next-generation sequencing or multiplex ligation-dependent probe amplification are
Externí odkaz:
https://doaj.org/article/25b2008149f745cca6329272592adb4c
Autor:
Christiane D. Much, Barbara S. Sendtner, Konrad Schwefel, Eric Freund, Sander Bekeschus, Oliver Otto, Axel Pagenstecher, Ute Felbor, Matthias Rath, Stefanie Spiegler
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits. Our unders
Externí odkaz:
https://doaj.org/article/6235fddf84474db1b2750edac3925c4f
Autor:
Robert A. Eder, Maaike van den Boomen, Salva R. Yurista, Yaiel G. Rodriguez-Aviles, Mohammad Rashedul Islam, Yin-Ching Iris Chen, Lena Trager, Jaume Coll-Font, Leo Cheng, Haobo Li, Anthony Rosenzweig, Christiane D. Wrann, Christopher T. Nguyen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/53fbca05ae4e4986aef594f4a666d293
Autor:
Christiane D. Much, Konrad Schwefel, Dariush Skowronek, Loay Shoubash, Felix von Podewils, Miriam Elbracht, Stefanie Spiegler, Ingo Kurth, Agnes Flöel, Henry W. S. Schroeder, Ute Felbor, Matthias Rath
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Autosomal dominant cerebral cavernous malformation (CCM) represents a genetic disorder with a high mutation detection rate given that stringent inclusion criteria are used and copy number variation analyses are part of the diagnostic workflow. Pathog
Externí odkaz:
https://doaj.org/article/aa2a460795ba46208c7cdfca7b23fa83
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 7, Pp n/a-n/a (2019)
Abstract Background The CRISPR/Cas9 system has opened new perspectives to study the molecular basis of cerebral cavernous malformations (CCMs) in personalized disease models. However, precise genome editing in endothelial and other hard‐to‐transf
Externí odkaz:
https://doaj.org/article/e4129c3e1bc240e19044df029e923c5f
Publikováno v:
Anais Brasileiros de Dermatologia, Vol 84, Iss 1, Pp 82-84 (2009)
Lentigo maligno é um melanoma in situ que mais comumente surge em áreas expostas à radiação ultravioleta, nos pacientes idosos. O tratamento é realizado, principalmente, para minimizar o risco de progressão para lentigo maligno melanoma. O pre
Externí odkaz:
https://doaj.org/article/9c2823b148eb4488aaf239b729a8ecaf
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75703 (2013)
BACKGROUND: Obesity is a risk factor for various types of infectious diseases and cancer. The increase in adipose tissue causes alterations in both adipogenesis and the production of adipocyte-secreted proteins (adipokines). Since natural killer (NK)
Externí odkaz:
https://doaj.org/article/fbbc29a2fc8a4267bdc8eeba3683ffe7
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24332 (2011)
The Rab family of Ras-related GTPases are part of a complex signaling circuitry in eukaryotic cells, yet we understand little about the mechanisms that underlie Rab protein participation in such signal transduction networks, or how these networks are
Externí odkaz:
https://doaj.org/article/6f6f20a483de47ce890c723dfb46877c