Investigating the association between osteopenia and bowel perforation through a multicenter radiologic analysis

Autor: Sebastian Sanduleanu, Koray Ersahin, Jonathan Kottlors, Johannes Bremm, Narmin Talibova, Tim Damer, Merve Erdogan, Nils Groβe Hokamp, Lukas Goertz, Nijat Nasirov, Vilayat Valiyev, Christiane Bruns, David Maintz, Nuran Abdullayev

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)

Abstract Anecdotal evidence from preliminary observations has noted multiple instances where osteoporosis is present in elderly patients before the clinical detection of bowel disease, even in the absence of overt gastrointestinal symptoms. However,

Externí odkaz: https://doaj.org/article/83aa2898aaf44f3dba2b13667b7e6592

Impact of FAPI-46/dual-tracer PET/CT imaging on radiotherapeutic management in esophageal cancer

Autor: Simone Wegen, Karina Claus, Philipp Linde, Johannes Rosenbrock, Maike Trommer, Thomas Zander, Armin Tuchscherer, Christiane Bruns, Hans Anton Schlößer, Wolfgang Schröder, Marie-Lisa Eich, Thomas Fischer, Klaus Schomäcker, Alexander Drzezga, Carsten Kobe, Katrin Sabine Roth, Jasmin Josefine Weindler

Publikováno v: Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)

Abstract Background Fibroblast activation protein (FAP) is expressed in the tumor microenvironment (TME) of various cancers. In our analysis, we describe the impact of dual-tracer imaging with Gallium-68-radiolabeled inhibitors of FAP (FAPI-46-PET/CT

Externí odkaz: https://doaj.org/article/ce5d14ae5759413998c9bebf6d8a92b5

Type of calcineurin inhibitor and long-term outcomes following liver transplantation in patients with primary biliary cholangitis – an ELTR study

Autor: Maria C. van Hooff, Rozanne C. de Veer, Vincent Karam, Rene Adam, Pavel Taimr, Wojciech G. Polak, Hasina Pashtoun, Sarwa Darwish Murad, Christophe Corpechot, Darius Mirza, Michael Heneghan, Peter Lodge, Gabriel C. Oniscu, Douglas Thorburn, Michael Allison, Herold J. Metselaar, Caroline M. den Hoed, Adriaan J. van der Meer, Gabriel Oniscu, Johann Pratschke, Derek Manas, William Bennet, Pal-Dag Line, Emir Hot, Krzysztof Zieniewicz, Bo Goran Ericzon, Jiri Fronek, Jurgen L. Klempnauer, Allan Rasmussen, Renato Romagnoli, Petr Nemec, Arno Nordin, Andreas Paul, Paolo De Simone, R.J. Porte, Gabriela Berlakovich, Daniel Cherqui, Jacques Pirenne, Etienne Sokal, Giorgio Rossi, Daniel Candinas, Philippe Bachellier, Oleg Rummo, Karim Boudjema, Anna Mrzljak, Olivier Soubrane, Herold Metselaar, Stefan Schneeberger, Francis Navarro, Thierry Berney, Christophe Duvoux, Michele Colledan, Luciano De Carlis, Olivier Boillot, Jean Hardwigsen, Francois Rene Pruvot, Bertrand Suc, Marco Vivarelli, Pierre Alain Clavien, Hauke Lang, Maciej Kosieradzki, Frederik Berrevoet, Bruno Heyd, Matteo Cescon, Laurence Chiche, Eberhard Kochs, Umberto Baccarani, Olivier Detry, Michael Bartels, Massimo Rossi, Olivier Scatton, Vasileios Papanikolaou, Ian Alwayn, Peter Schemmer, N. Senninger, Christian Ducerf, Fabrizio Di Benedetto, Giuseppe Tisone, Silvio Nadalin, Zoltan Mathe, Marija Ribnikar, Utz Settmacher, Thomas Becker, Nuno Silva, Jorge Daniel, Irinel Popescu, Valerio Lucidi, Wolf O. Bechstein, Thomas Decaens, Jean Gugenheim, Salvatore Gruttadauria, Frausto Zamboni, Murat Zeytunlu, Jorg C. Kalff, Toomas Vali, Yaman Tokat, Ernst Klar, Julius Janek, Murat Kilic, Krum Katzarov, Lutz Fisher, Emmanuel Buc, Marco Castagneto, Tarkan Unek, Lubomir Spassov, Dirk Stippel, Christiane Bruns, Hans Schlitt, Ephrem Salame, Piotr Kalicinski, Koray Acarli

Publikováno v: JHEP Reports, Vol 6, Iss 8, Pp 101100- (2024)

Background & Aims: Tacrolimus has been associated with recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT), which in turn may reduce survival. This study aimed to assess the association between the type of calcineurin inh

Externí odkaz: https://doaj.org/article/c0595d19bc354a8797ef79da5ed77889

LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

Autor: Alexander F. vom Stein, Rocio Rebollido-Rios, Anna Lukas, Maximilian Koch, Anton von Lom, Sebastian Reinartz, Daniel Bachurski, France Rose, Katarzyna Bozek, Ali T. Abdallah, Viktoria Kohlhas, Julia Saggau, Rebekka Zölzer, Yue Zhao, Christiane Bruns, Paul J. Bröckelmann, Philipp Lohneis, Reinhard Büttner, Björn Häupl, Thomas Oellerich, Phuong-Hien Nguyen, Michael Hallek

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

The survival of chronic lymphocytic leukemia cells strongly depends on the presence of a supportive microenvironment. Here, the authors show that LYN kinase is essential for the reprogramming of stromal cells towards a leukemia-supportive phenotype t

Externí odkaz: https://doaj.org/article/5884daf4f87c4769b8607b371a457bb5

Integrin beta1 (ITGB1) as a prognostic marker in esophageal adenocarcinoma

Autor: Alexander I. Damanakis, Isabell Wahler, Hans Fuchs, Heike Löser, Wolfgang Schröder, Thomas Zander, Seung-Hun Chon, Christiane Bruns, Alexander Quaas, Florian Gebauer

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)

Abstract Today, individual prognosis in patients with adenocarcinoma of the esophagus (EAC) is based on post-surgical TNM staging and valid biomarkers are still not implemented. Integrin beta1 (ITGB1) is widely expressed in epithelial cells and promo

Externí odkaz: https://doaj.org/article/8a80e0a2b5c84f779a30dbf7d1d4a1cf