Intracellular Peptides in Cell Biology and Pharmacology

Autor: Christiane B. de Araujo, Andrea S. Heimann, Ricardo A. Remer, Lilian C. Russo, Alison Colquhoun, Fábio L. Forti, Emer S. Ferro

Publikováno v: Biomolecules, Vol 9, Iss 4, p 150 (2019)

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracel

Externí odkaz: https://doaj.org/article/d3ce3ad7d3864fa293cfb66a60311681

Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms

Autor: Saloe Bispo, Ariel Mariano Silber, José S. L. Patané, M. Carolina Elias, Julia Pinheiro Chagas da Cunha, Christiane B. de Araujo, Alex Ranieri Jerônimo Lima

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Pathogens, Vol 17, Iss 1, p e1009272 (2021)
PLoS Pathogens

Trypanosoma cruzi alternates between replicative and nonreplicative life forms, accompanied by a shift in global transcription levels and by changes in the nuclear architecture, the chromatin proteome and histone posttranslational modifications. To g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48433a39ec4f4f5c46907a62459cc9f1

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

Autor: Christiane B. de Araujo, Andréa Rodrigues Ávila, Marcelo S. Reis, Bruno B. Scholl, Priscila M. Hiraiwa, Gustavo R. Cayres-Silva, Paula A. Marin, Marcela O. Vitarelli, Maria Carolina Elias, Richard McCulloch, Marcelo Santos da Silva

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports

The co-synthesis of DNA and RNA potentially generates conflicts between replication and transcription, which can lead to genomic instability. In trypanosomatids, eukaryotic parasites that perform polycistronic transcription, this phenomenon and its c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b341b8bad9f1b2e346a4ad17e4c83c3
https://doi.org/10.1038/s41598-019-54366-w

Interferon-gamma activity is potentiated by an intracellular peptide derived from the human 19S ATPase regulatory subunit 4 of the proteasome

Autor: Jean Pierre Schatzmann Peron, Lilian C. Russo, Osvaldo A. Sant'Anna, Fabio C. Gozzo, Emer S. Ferro, Christiane B. de Araujo, Elisabete R. do Monte, Cristiano Rossato, Leandro M. Castro, Ricardo Pariona Llanos, Vanessa Rioli

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Hundreds of intracellular peptides that are neither antigens nor neuropeptides are present in mammalian cells and tissues. These peptides correspond to fragments of cytosolic, nuclear or mitochondrial proteins. Proteasome inhibition affects the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ec9367cb30e5a520494e3747859b4
https://doi.org/10.1016/j.jprot.2016.08.003

Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi

Autor: Loyze Paola Oliveira de Lima, Simone Guedes Calderano, Marcelo Santos da Silva, Christiane B. de Araujo, Stenio Perdigão Fragoso, Elton J R Vasconcelos, Claudio A. Pereira, Leo Kei Iwai, M. Carolina Elias

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

DNA polymerase theta (Polθ), a member of the DNA polymerase family A, exhibits a polymerase C-terminal domain, a central domain, and an N-terminal helicase domain. Polθ plays important roles in DNA repair via its polymerase domain, regulating genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6c034d1db1e6ddd787b08e93dba47b
https://eprints.whiterose.ac.uk/146416/1/s41598-019-39348-2.pdf