SLP-2 is required for stress-induced mitochondrial hyperfusion

Autor: Christiane Alexander, Carsten Merkwirth, Sandrine Da Cruz, Stéphanie Grandemange, David C. Chan, Frank Krause, Sarah Ehses, Yves Benoît Mattenberger, Sébastien Herzig, Ines Raschke, Thomas Langer, Daniel Tondera, Pascaline Clerc, Alexis A. Jourdain, Jean-Claude Martinou, Mariusz Karbowski, Christoph Ruediger Bauer, Richard J. Youle

Publikováno v: EMBO Journal, Vol. 28, No 11 (2009) pp. 1589-600
EMBO Journal
EMBO Journal, EMBO Press, 2009, 28 (11), pp.1589-1600. ⟨10.1038/emboj.2009.89⟩
EMBO J

International audience; Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin‐related GTPases, the mitofusins (MFN1 and 2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03537545079b9a066668b7ff7ec45a41
https://archive-ouverte.unige.ch/unige:18589

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Autor: Hsiuchen Chen, Maja Fiket, Zhiyin Song, David C. Chan, Christiane Alexander

Publikováno v: The Journal of Cell Biology

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) spl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89339d27c90cf6ec112b2951975d381e
https://resolver.caltech.edu/CaltechAUTHORS:SONjcb07

OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance

Autor: Bernhard Jurklies, Ulrich Kellner, Eckart Apfelstedt-Sylla, Beate Leo-Kottler, Simone Mayer, Christiane Alexander, Bernd Wissinger, Eberhart Zrenner, Ulrike E.A. Pesch

Publikováno v: Human molecular genetics. 10(13)

We and others have shown recently that mutations in the OPA1 gene encoding a dynamin-related mitochondrial protein cause autosomal dominant optic atrophy (ADOA) linked to chromosome 3q28-q29. Here we report screening of the OPA1 gene in a sample of 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37b308752d0c992168942cf195ea55f
https://pubmed.ncbi.nlm.nih.gov/11440988

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

Autor: Ulrike E.A. Pesch, Ulrich Kellner, Georg Auburger, Dawn L. Thiselton, Christiane Alexander, Marcela Votruba, Bernd Wissinger, Miguel Rodríguez, Shomi S. Bhattacharya, Anthony T. Moore, Beate Leo-Kottler, Simone Mayer

Publikováno v: Nature genetics. 26(2)

Autosomal dominant optic atrophy (ADOA) is the most prevalent hereditary optic neuropathy resulting in progressive loss of visual acuity, centrocoecal scotoma and bilateral temporal atrophy of the optic nerve with an onset within the first two decade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78c7413e61c2e0da3a1dfdc89ad8d0a
https://pubmed.ncbi.nlm.nih.gov/11017080

Identification of the physiological promoter for spinocerebellar ataxia 2 gene reveals a CpG island for promoter activity situated into the exon 1 of this gene and provides data about the origin of the nonmethylated state of these types of islands

Autor: Joachim Nowok, Jorge Aguiar, Wolfgang Schulz, Suzana Gispert, Christiane Alexander, Doda Rudnicki, Georg Auburger, Simon Santurlidis

Publikováno v: Biochemical and biophysical research communications. 254(2)

In order to further use the spinocerebellar ataxia 2 (SCA2) promoter for transgenic mice models of “CAG repeat” neurodegeneration, different fragments of this 5′ end were ligated into pGL3-Luc plasmid to obtain the better promoter-activity of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117266917f21ca1c255366b373bbe857
https://pubmed.ncbi.nlm.nih.gov/9918835