Výsledky vyhledávání - "Christiane Guguen-Guillouzo"

Akademický článek

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

Autor: Audrey Burban, Ahmad Sharanek, Romain Hüe, Marion Gay, Sylvain Routier, André Guillouzo, Christiane Guguen-Guillouzo

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Abstract The penicillinase-resistant antibiotics (PRAs), especially the highly prescribed flucloxacillin, caused frequent liver injury via mechanisms that remain largely non-elucidated. We first showed that flucloxacillin, independently of cytotoxici

Externí odkaz: https://doaj.org/article/b1289589be8c461f93dd1eb5e8e48493

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Akademický článek

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Autor: Georg Tascher, Audrey Burban, Sandrine Camus, Marine Plumel, Stéphanie Chanon, Remy Le Guevel, Valery Shevchenko, Alain Van Dorsselaer, Etienne Lefai, Christiane Guguen-Guillouzo, Fabrice Bertile

Publikováno v: Cells, Vol 8, Iss 2, p 192 (2019)

Of the hepatic cell lines developed for in vitro studies of hepatic functions as alternatives to primary human hepatocytes, many have lost major liver-like functions, but not HepaRG cells. The increasing use of the latter worldwide raises the need fo

Externí odkaz: https://doaj.org/article/bf6ee72a9e84431a80f1e7b1a3047602

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Antibiotics-induced oxidative stress

Autor: Christiane Guguen-Guillouzo, André Guillouzo

Publikováno v: Current Opinion in Toxicology
Current Opinion in Toxicology, 2020, 20-21, pp.23-28. ⟨10.1016/j.cotox.2020.03.004⟩
Current Opinion in Toxicology, [Amsterdam] : Elsevier B.V., [2016]-, 2020, 20-21, pp.23-28. ⟨10.1016/j.cotox.2020.03.004⟩

This review comes from a themed issue on Oxidative Toxicology; Edited by Yvonne Will, Moorthy Bhagavatula, Martin van den Berg and Jose Manautou; International audience; Around one hundred drugs of our modern pharmacopeia are efficacious and useable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bd2a3e010896473841c326f33e2cff
https://univ-rennes.hal.science/hal-02569990

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Akademický článek

Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices

Autor: Francis Finot, Régis Masson, Fabienne Desmots, Catherine Ribault, Nicole Bichet, Joan A. Vericat, Patricia Lafouge, Christiane Guguen-Guillouzo, Pascal Loyer

Publikováno v: International Journal of Hepatology, Vol 2012 (2012)

The culture liver slices are mainly used to investigate drug metabolism and xenobiotic-mediated liver injuries while apoptosis and proliferation remain unexplored in this culture model. Here, we show a transient increase in LDH release and caspase ac

Externí odkaz: https://doaj.org/article/faeeaa5398634ad9b5bd3441fc534ab1

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Akademický článek

Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment.

Autor: Ludovic Donaghy, Florian Cabillic, Anne Corlu, Octavie Rostan, Olivier Toutirais, Christiane Guguen-Guillouzo, Claude Guiguen, Jean-Pierre Gangneux

Publikováno v: PLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e703 (2010)

BACKGROUND: Recent advances demonstrated that liver dendritic cells (DCs) promote immunologic hyporesponsiveness that may contribute to hepatic tolerance. Although there has been significant work on the phenotypic and functional roles of such DCs, th

Externí odkaz: https://doaj.org/article/d6073ba4af774d28b05ed80e97b5bc87

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From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

Autor: Ahmad Sharanek, Audrey Burban, Matthew Burbank, Richard J. Weaver, Hervé Mialanne, Hélène Aerts, Christiane Guguen-Guillouzo, André Guillouzo

Publikováno v: Toxicological Sciences
Toxicological Sciences, 2017, 157 (2), pp.451-464. ⟨10.1093/toxsci/kfx062⟩
Toxicological Sciences, Oxford University Press (OUP), 2017, 157 (2), pp.451-464. ⟨10.1093/toxsci/kfx062⟩

Impacell; International audience; Several endothelin receptor antagonists (ERAs) have been developed for the treatment of pulmonary arterial hypertension (PAH). Some of them have been related to clinical cases of hepatocellular injury (sitaxentan [SI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a43c1a1c62a7d368edde03e1fb538f
https://doi.org/10.1093/toxsci/kfx062

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Setup and Use of HepaRG Cells in Cholestasis Research

Autor: Christiane, Guguen-Guillouzo, André, Guillouzo

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1981

Since HepaRG cells can differentiate into well-polarized mature hepatocyte-like cells that synthesize, conjugate, and secrete bile acids, they represent an appropriate surrogate to primary human hepatocytes for investigations on drug-induced cholesta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a516c0f219d3a16123d666741fed053a
https://pubmed.ncbi.nlm.nih.gov/31016662

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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Autor: Alain Van Dorsselaer, Etienne Lefai, Georg Tascher, Valery Shevchenko, Christiane Guguen-Guillouzo, Stéphanie Chanon, Sandrine Camus, Marine Plumel, Fabrice Bertile, Audrey Burban, Rémy Le Guével

Publikováno v: Cells
Volume 8
Issue 2
Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩
Cells, MDPI, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩
Cells, Vol 8, Iss 2, p 192 (2019)
Cells 2 (8), 1-25. (2019)

International audience; Of the hepatic cell lines developed for in vitro studies of hepatic functions as alternatives to primary human hepatocytes, many have lost major liver-like functions, but not HepaRG cells. The increasing use of the latter worl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1800427da035d0d84d82d0e71ec1e1

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Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential

Autor: Audrey Burban, Lydie Humbert, Thibaut Eguether, Christiane Guguen-Guillouzo, Ahmad Sharanek, André Guillouzo, Dominique Rainteau

Publikováno v: Toxicological Sciences
Toxicological Sciences, 2019, 168 (2), pp.474-485. ⟨10.1093/toxsci/kfz009⟩
Toxicological Sciences, Oxford University Press (OUP), 2019, 168 (2), pp.474-485. ⟨10.1093/toxsci/kfz009⟩

Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile acids (BAs) in hepatocytes. However, little information exists on first changes in BA content

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62039b07f80126188d090c1a05aeb965
https://pubmed.ncbi.nlm.nih.gov/30629237

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Setup and use of HepaRG cells in cholestasis research

Autor: André Guillouzo, Christiane Guguen-Guillouzo

Publikováno v: Experimental Cholestasis Research
Experimental Cholestasis Research, 1981, Humana Press Inc., pp.291-312, 2019, ⟨10.1007/978-1-4939-9420-5_19⟩
Methods in Molecular Biology ISBN: 9781493994199

International audience; Since HepaRG cells can differentiate into well-polarized mature hepatocyte-like cells that synthesize, conjugate, and secrete bile acids, they represent an appropriate surrogate to primary human hepatocytes for investigations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa85a92ca7613f2c8cea9b0ec739858
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02161939

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