The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

Autor: Nicolas Jonckheere, Nicolas Skrypek, Johann Merlin, Anne Frédérique Dessein, Patrick Dumont, Emmanuelle Leteurtre, Ann Harris, Jean-Luc Desseyn, Christiane Susini, Frédéric Frénois, Isabelle Van Seuningen

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32232 (2012)

The mucin MUC4 and its membrane partner the ErbB2 oncogenic receptor are potential interacting partners in human pancreatic tumour development. However, the way they function is still largely unknown. In this work, we aimed to identify the cellular m

Externí odkaz: https://doaj.org/article/48bab8a579ea4254aca33411acbebd92

Current Scientific Rationale for the Use of Somatostatin Analogs and mTOR Inhibitors in Neuroendocrine Tumor Therapy

Autor: Siham Moatassim Billah, Mounira Chalabi, Stéphane Pyronnet, Delphine Vezzosi, Corinne Bousquet, Philippe Caron, Charline Lasfargues, Christiane Susini

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 97:727-737

Context: Among the innovative molecules used to manage neuroendocrine tumors, there is growing interest in combining the somatostatin analogs octreotide or pasireotide (SOM230) and everolimus (RAD001), an inhibitor that targets the protein kinase mam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a4ccbe5781fe4166070caef93b31587
https://doi.org/10.1210/jc.2011-2088

Juvenile hormone binding protein traffic — Interaction with ATP synthase and lipid transfer proteins

Autor: Agata Kochman, Andrzej Ożyhar, Frédéric Lopez, Marian Kochman, Marta Zalewska, Karima Chaoui, Jean-Pierre Estève, Christiane Susini

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2009, epub ahead of print. ⟨10.1016/j.bbamem.2009.04.022⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2009, epub ahead of print. ⟨10.1016/j.bbamem.2009.04.022⟩

International audience; Juvenile hormone (JH) controls insect development, metamorphosis and reproduction. In insect hemolymph a significant proportion of JH is bound to juvenile hormone binding protein (JHBP), which serves as a carrier supplying the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c68362ae1b75e7c786d9793e58641e4

Indium-111–Pentetreotide Scintigraphy and Somatostatin Receptor Subtype 2 Expression: New Prognostic Factors for Malignant Well-Differentiated Endocrine Tumors

Autor: Rosine Guimbaud, Amani Asnacios, Eric Bauvin, Philippe Rochaix, Frédéric Courbon, Valérie Cances-Lauwers, Louis Buscail, Andrée Boneu, Stefan Schulz, Christiane Susini

Publikováno v: Journal of Clinical Oncology. 26:963-970

Purpose Well-differentiated metastatic endocrine carcinomas are difficult to manage because of variable disease outcome. New prognostic factors are required. These tumors overexpress somatostatin receptors (sst), implying the use of somatostatin anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cc68417c424b60b5149c794f2286d7
https://doi.org/10.1200/jco.2007.12.7431

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

Autor: Corinne Bousquet, Lucien Pradayrol, Bernard Monsarrat, Elodie Archer-Lahlou, Christiane Susini, Daniel Fourmy, Marjorie Fanjul, Jean-Pierre Estève, Carole Pichereaux, Julie Guillermet-Guibert, Frédéric Lopez, Nathalie Saint-Laurent, Audrey Ferrand

Publikováno v: The EMBO Journal. 25:3943-3954

Phosphatidylinositol 3-kinase (PI3K) regulates many cellular functions including growth and survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through its G protein-coupled receptor (GPCR) sst2, has potent proapoptot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655ab99a39d3bba0ae4fa7f3abd81af8
https://doi.org/10.1038/sj.emboj.7601279