Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter

Autor: Spyros, Batzios, Galit, Tal, Andrew T, DiStasio, Yanyan, Peng, Christiana, Charalambous, Paola, Nicolaides, Erik-Jan, Kamsteeg, Stanley H, Korman, Hanna, Mandel, Peter J, Steinbach, Ling, Yi, Summer R, Fair, Mark E, Hester, Anthi, Drousiotou, Stephen G, Kaler

Publikováno v: Human Molecular Genetics. 31:4121-4130

The high-affinity copper transporter CTR1 is encoded by CTR1 (SLC31A1), a gene locus for which no detailed genotype–phenotype correlations have previously been reported. We describe identical twin male infants homozygous for a novel missense varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b746f24ea60c92475c8e98970568515
https://doi.org/10.1093/hmg/ddac156

LC-HRMS/MS phytochemical profiling of Vernonia kotschyana Sch. Bip. ex Walp.: Potential involvement of highly-oxygenated stigmastane-type saponins in cancer cell viability, apoptosis and intracellular ROS production

Autor: Alexandru Vasincu, Anca Miron, Krystyna Skalicka-Woźniak, Christiana M. Neophytou, Simon Vlad Luca, Christiana Charalambous

Publikováno v: South African Journal of Botany. 144:83-91

Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) is a traditional African medicinal plant used to treat gastritis, gastroduodenal ulcers, tuberculosis, arthritis, headaches and wounds. The aim of this study was to evaluate the effect of different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8680f213f5795d9cf2a0047adc9b718
https://doi.org/10.1016/j.sajb.2021.09.003

Joint modelling of longitudinal measurements and survival times via a multivariate copula approach

Autor: Zili Zhang, Christiana Charalambous, Peter Foster

Publikováno v: Zhang, Z, Charalambous, C & Foster, P 2022, ' Joint modelling of longitudinal measurements and survival times via a multivariate copula approach ', Journal of Applied Statistics . https://doi.org/10.1080/02664763.2022.2081965

Joint modelling of longitudinal and time-to-event data is usually described by a joint model which uses shared or correlated latent effects to capture associations between the two processes. Under this framework, the joint distribution of the two pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7ac23c39975010c227d4ffbe673d58
https://pure.manchester.ac.uk/ws/files/250553577/Joint_modelling_of_longitudinal_measurements_and_survival_times_via_a_multivariate_copula_approach.pdf

A Gaussian copula joint model for longitudinal and time-to-event data with random effects

Autor: Zili Zhang, Christiana Charalambous, Peter Foster

Publikováno v: Zhang, Z, Charalambous, C & Foster, P 2023, ' A Gaussian copula joint model for longitudinal and time-to-event data with random effects ', Computational Statistics & Data Analysis, vol. 181, 107685 . https://doi.org/10.1016/j.csda.2022.107685

Longitudinal and survival sub-models are two building blocks for joint modelling of longitudinal and time to event data. Extensive research indicates separate analysis of these two processes could result in biased outputs due to their associations. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa183738ede702c16dd0bcaba86dc65
https://doi.org/10.1016/j.csda.2022.107685

Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols

Autor: Dimitrios Kanakis, Constantina Constantinou, Christiana Charalambous

Publikováno v: European Journal of Nutrition. 59:845-857

Despite significant advances in the diagnosis and treatment of cancer, the latter still remains a fatal disease due to the lack of prevention, early diagnosis, and effective drugs. Radiotherapy, chemotherapy, and surgery are not only expensive but pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be6602dae501557f6917f733b2a0884
https://doi.org/10.1007/s00394-019-01962-1