PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.

Autor: Maude Rolland, Xiaojun Li, Yann Sellier, Hélène Martin, Teresa Perez-Berezo, Benjamin Rauwel, Alexandra Benchoua, Bettina Bessières, Jacqueline Aziza, Nicolas Cenac, Minhua Luo, Charlotte Casper, Marc Peschanski, Daniel Gonzalez-Dunia, Marianne Leruez-Ville, Christian Davrinche, Stéphane Chavanas

Publikováno v: PLoS Pathogens, Vol 12, Iss 4, p e1005547 (2016)

Congenital infection by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae of the central nervous system, including sensorineural deafness, cerebral palsies or devastating neurodevelopmental abnormalities (0.1% of all births). To g

Externí odkaz: https://doaj.org/article/edcbfbf893b7443abcdf787f705e6267

Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures.

Autor: Kaoutar Leghmar, Nicolas Cenac, Maude Rolland, Hélène Martin, Benjamin Rauwel, Justine Bertrand-Michel, Pauline Le Faouder, Mélinda Bénard, Charlotte Casper, Christian Davrinche, Thierry Fournier, Stéphane Chavanas

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132627 (2015)

Congenital infection by human cytomegalovirus (HCMV) is a leading cause of congenital abnormalities of the central nervous system. Placenta infection by HCMV allows for viral spread to fetus and may result in intrauterine growth restriction, preeclam

Externí odkaz: https://doaj.org/article/9f1035d0dba346f4af46e56915e9b74e

Comprehensive analysis of human cytomegalovirus microRNA expression during lytic and quiescent infection.

Autor: Zhang-Zhou Shen, Xing Pan, Ling-Feng Miao, Han-Qing Ye, Stéphane Chavanas, Christian Davrinche, Michael McVoy, Min-Hua Luo

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88531 (2014)

BackgroundHuman cytomegalovirus (HCMV) encodes microRNAs (miRNAs) that function as post-transcriptional regulators of gene expression during lytic infection in permissive cells. Some miRNAs have been shown to suppress virus replication, which could h

Externí odkaz: https://doaj.org/article/e8b24b9da1bb4d6281887e493409ffac

MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a

Autor: Simon Rayner, Min-Hua Luo, Edward S. Mocarski, Michael A. McVoy, Guan-Hua Qiao, Bo Yang, Xi-Juan Liu, Zhang-Zhou Shen, Han-Qing Ye, Qiyi Tang, Cong-Cong Wu, Ling-Feng Miao, Jiafu Li, Xiao-Jun Li, Christian Davrinche, William J. Britt, Stéphane Chavanas, Ya-Ru Fu

Publikováno v: Journal of Virology. 89:1070-1082

Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological disorders. HCMV infection alters expression of cellular microRNAs (miRs) and induces cell cycle arrest, which in turn modifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f460e4076365d70e29b21a7d9d60c56
https://doi.org/10.1128/jvi.01740-14

Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells

Autor: Suzanne Peyrottes, Eric Champagne, Charline Daguzan, Christian Davrinche, Morgane Moulin, Hanna Kulyk-Barbier

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 196 (5), pp.2219-2229. ⟨10.4049/jimmunol.1501661⟩
Journal of Immunology, 2016, 196 (5), pp.2219-2229. ⟨10.4049/jimmunol.1501661⟩

Human V gamma 9V delta 2 T cells are activated through their TCR by neighboring cells producing phosphoantigens. Zoledronate (ZOL) treatment induces intracellular accumulation of the phosphoantigens isopentenyl pyrophosphate and ApppI. Few attempts h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb90cf91f93a97be4d52664ed4c92bf
https://hal.archives-ouvertes.fr/hal-02408121