Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian Zwingelstein"'
Autor:
Gail Thomas, Shiao-Pei Weathers, Vinay K. Puduvalli, Christian Zwingelstein, Julie Rood-Breithaupt, John de Groot, W. K. Alfred Yung, Marianna Manfrini, Marta Penas-Prado
Publikováno v:
Neuro-oncology Advances
Background There is an urgent need for additional therapies to treat recurrent glioblastoma (GBM). Preclinical studies suggest that high dose macitentan, an oral dual endothelin receptor antagonist, enhances the cytotoxic effects of temozolomide (TMZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e74965a99b166c957b0bd137b90a018
https://doi.org/10.1093/noajnl/vdab141
https://doi.org/10.1093/noajnl/vdab141
Autor:
Richard W. D. Welford, Jasper Dingemanse, Daniel Oder, Nicolas Guérard, Christian Zwingelstein, Peter Nordbeck, Olivier Morand, Christoph Wanner
Publikováno v:
Clinical pharmacology and therapeutics. 103(4)
Lucerastat is a glucosylceramide synthase inhibitor aimed at reducing production of glycosphingolipids (GSLs), including those accumulating in Fabry disease. The safety, tolerability, pharmacodynamics, and pharmacokinetics of oral lucerastat were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d18d5ba0ae35e7e6546c9875a94644
https://pubmed.ncbi.nlm.nih.gov/28699267
https://pubmed.ncbi.nlm.nih.gov/28699267
Publikováno v:
Basicclinical pharmacologytoxicology. 118(5)
Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-20442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47a53ba1698df6b88c2d145946641eb
https://pubmed.ncbi.nlm.nih.gov/26525450
https://pubmed.ncbi.nlm.nih.gov/26525450
Strategies for the NMR-Based Identification and Optimization of Allosteric Protein Kinase Inhibitors
Autor:
Christian Zwingelstein, Marcel J. J. Blommers, Wolfgang Jahnke, César Fernández, René Amstutz
Publikováno v:
ChemBioChem. 6:1607-1610
Protein kinases are important drug targets, but kinase inhibitors ought to be selective and specific in order to avoid side effects in the clinic. Kinase inhibitors that do not target the highly conserved ATP-binding site, but that target an alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6cdb3b7e4f4715461506581542fc70
https://doi.org/10.1002/cbic.200500100
https://doi.org/10.1002/cbic.200500100
Publikováno v:
Molecular Genetics and Metabolism. 120:S59
Lucerastat, an inhibitor of glucosylceramide synthase, has the potential for substrate reduction therapy in glycosphingolipid storage disorders such as Fabry disease. In pharmacokinetic studies in rats, dogs, and healthy subjects, the main route of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26680e643ef6fffaefc0cea92422004
https://doi.org/10.1016/j.ymgme.2016.11.131
https://doi.org/10.1016/j.ymgme.2016.11.131
Autor:
Philipp Krastel, Srinivasa P. S. Rao, Douglas Jeffery, Luis R. Camacho, Christian Zwingelstein, Pornwaratt Niyomrattanakit, Jun Zheng, Kevin Pethe, Christian G. Noble, Vivian Lim, Silvio Roggo, Melvin Au, David Beer, Vasan K. Sambandamurthy, Esther K. Schmitt, Meliana Riwanto, Charlotte Miault
Publikováno v:
Angewandte Chemie. 123:6011-6013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5270e01c0de9bd72a2694f8984e1d
https://doi.org/10.1002/ange.201101740
https://doi.org/10.1002/ange.201101740
Autor:
Claus Peckelsen, James C. Stolzenbach, Ville Pettilä, Vincent Shu, Stuart Simon, Abla A. Creasey, Christopher J. Doig, Edward Abraham, Russell Postier, Bruce Light, Konrad Reinhart, Judy Stone, Herbert Spapen, Charles L. Sprung, Petr Svoboda, Lona Poole, Jeffrey Tobias, Sandra Percell, Steven M. Opal, Ignace Demeyer, Cathy De Deyne, Allan Seibert, Christian Zwingelstein, Antonio Artigas, Pierre-François Laterre, Angel López Rodriguez, Richard Beale
Publikováno v:
JAMA. 290(2)
Context The expression and release of tissue factor is a major trigger for the activation of coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa3ec05bc299e6b9e5c9b054ef61ede
https://pubmed.ncbi.nlm.nih.gov/12851282
https://pubmed.ncbi.nlm.nih.gov/12851282
Autor:
Konrad Reinhart, Thomas Butler, Christian Zwingelstein, Sandra Percell, Abla A. Creasey, Petr Svoboda, Anthony R. Dal Nogare, Derk Olthoff, Gunter Hempelmann, Allan Seibert, Russell Postier, Anton Leighton, Eike Martin, Edward Abraham, Vincent Shu
Publikováno v:
Critical care medicine. 29(11)
To identify a safe and potentially effective recombinant tissue factor pathway inhibitor (rTFPI) dose for further clinical evaluation in patients with severe sepsis.Prospective, randomized, single-blind, placebo-controlled, dose escalation, multicent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b37770e206ab23de8439b15c089636
https://pubmed.ncbi.nlm.nih.gov/11700399
https://pubmed.ncbi.nlm.nih.gov/11700399
Autor:
Thomas Butler, Christian Zwingelstein, Ellis H. Tobin, Werner Lesslauer, Hajo A. Bruining, Kenneth A. Kudsk, Michel P. Glauser, Jorge Garbino, Edward Abraham, Anton Leighton, Charles W. Otto, Pierre F. Laterre, David Gelmont
Publikováno v:
JAMA-Journal of the American Medical Association, 277(19), 1531-1538. American Medical Association
Objective. —To evaluate the safety and efficacy of p55 tumor necrosis factor receptor fusion protein, a recombinant chimeric protein of human p55 (type I) tumor necrosis factor receptor (CD120a) extracellular domain and lgG1 sequences (referred to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd3f798a82e1c2a5075dc6e44fd6a4a
https://doi.org/10.1001/jama.1997.03540430043031
https://doi.org/10.1001/jama.1997.03540430043031
Autor:
Wolfgang Jahnke, Marcel J. J. Blommers, César Fernández, Christian Zwingelstein, René Amstutz
Publikováno v:
ChemBioChem; Sep2005, Vol. 6 Issue 9, p1607-1610, 4p