Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christian Zechel"'
Publikováno v:
International Journal of Peptide and Protein Research. 32:468-475
The synthetic glucagon analogues [Glu21]glucagon, 2, and [Lys17,18,Glu21]glucagon, 3, were designed using Chou-Fasman calculations for the purpose of enhancing the probability for the formation of a C-terminal amphipathic alpha-helical conformation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26485c72b51eb9de2059a04329bc29da
https://doi.org/10.1111/j.1399-3011.1988.tb01377.x
https://doi.org/10.1111/j.1399-3011.1988.tb01377.x
Publikováno v:
International Journal of Peptide and Protein Research. 25:267-279
Four conformationally restricted cyclic enkephalin analogs of the type Tyr-cyclo(-Nω -Xxx-Gly-Phe-Leu-) with Xxx = l-Orn, d-Orn, l-Lys and d-Lys have been synthesized by conventional methods and the conformation of the Bocprotected, the deprotected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5947a2712737fdb3bbdb8f1db443a5f
https://doi.org/10.1111/j.1399-3011.1985.tb02174.x
https://doi.org/10.1111/j.1399-3011.1985.tb02174.x
Autor:
Jürgen Delzer, Wilfried Hornberger, Christian Zechel, Gisela Backfisch, Thomas Subkowski, Andreas Kling, Werner Seitz, Claudia Isabella Graef, Udo E.W Lange, Hervé Geneste, Arnulf Lauterbach
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:165-169
Solid-phase synthesis and SAR of alpha(V)beta(3)-receptor antagonists based on a N(1)-substituted 4-amino-1H-pyrimidin-2-one scaffold are described. The most potent compounds exhibited IC(50) values towards alpha(V)beta(3) in the nano- to subnanomola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46b389f02a87c71234e971349a430b0
https://doi.org/10.1016/s0960-894x(02)00931-9
https://doi.org/10.1016/s0960-894x(02)00931-9
Autor:
Udo Lange, Claudia Isabella Graef, Thomas Subkowski, Gisela Backfisch, Wilfried Hornberger, Arnulf Lauterbach, Hervé Geneste, Christian Zechel, Jürgen Delzer, Andreas Kling
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1379-1382
Solid-phase synthesis and SAR of integrin alpha(V)beta3-receptor antagonists containing a urea moiety as non-basic guanidine mimetic are described. The most potent compounds exhibited IC(50) values towards alpha(V)beta3 in the nanomolar range and hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b393589d11872f1bdc969f5187bc92fb
https://doi.org/10.1016/s0960-894x(02)00161-0
https://doi.org/10.1016/s0960-894x(02)00161-0
Publikováno v:
Angewandte Chemie International Edition in English. 35:2288-2337
Combinatorial synthesis has developed within a few years from a laboratory curiosity to a method that is taken seriously in drug research. Rapid progress in molecular biology and the resulting ability to determine the activity of new substances extre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646343a23842904c661dd174fbe19bda
https://doi.org/10.1002/anie.199622881
https://doi.org/10.1002/anie.199622881
Autor:
Christian Zechel, Udo Lange
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1571-1573
A newly developed convergent solid-phase synthesis provides efficient access to thrombin inhibitors of the D-Phe-Pro-Arg type. Members of the synthesized libraries inhibited thrombin with IC(50)s in the nanomolar range.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcacd569404fe3fb7e86fc687290ee52
https://doi.org/10.1016/s0960-894x(02)00251-2
https://doi.org/10.1016/s0960-894x(02)00251-2
Autor:
Anne Scannell‐Lansky, Christian Zechel
Publikováno v:
Combinatorial Chemistry: A Practical Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a8ba82be1f02b6d8a57c70dcefae3c
https://doi.org/10.1002/9783527614141.ch08
https://doi.org/10.1002/9783527614141.ch08
Autor:
Andre Boelke, Emily Jane Canada, Brian Morgan Watson, Valentine J. Klimkowski, Michael Mohr, Qing Shi, David E. Timm, Shon Roland Pulley, Andreas Gerhard Weichert, Hans-Juergen Mest, J. Michael Kalbfleisch, Elizabeth A. Dingess-Hammond, Johann-Christian Zechel, Gerd Ruehter, Brandon J. Margolis, Soenke Petersen, Michael Robert Wiley, Graham N. Wishart, Annick J. Cauvin, Beatrice Renson, Stephen Parsons, Larry C. Blaszczak, Dirk Hankotius, Britta Evers, Scott Martin Sheehan
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(6)
A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1ec483258876005ba2cb852d33fbf0
https://pubmed.ncbi.nlm.nih.gov/17239592
https://pubmed.ncbi.nlm.nih.gov/17239592
Autor:
Anne Scannell-Lansky, Christian Zechel
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaecfc4ea4479849f4760bfc78e9eefe
https://doi.org/10.1002/chin.200309239
https://doi.org/10.1002/chin.200309239
Autor:
Christian Zechel
Publikováno v:
Combinatorial Chemistry: From Theory to Application, Volume 26, Second Revised Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb90581487781c30c75661d6fe4c0c8a
https://doi.org/10.1002/chin.200307265
https://doi.org/10.1002/chin.200307265