Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine

Autor: Christian Zaugg, Sandra Sanders-van Wijk, Nasser Davarzani, Micha T. Maeder, Joël Karel, Dirk Block, Matthias Pfisterer, Evgueni Smirnov, Peter Rickenbacher, Ralf Peeters, Hans-Peter Brunner-La Rocca, Thomas M. Suter, Vinzent Rolny, Rudolf A. de Boer

Publikováno v: The EPMA Journal, 9(2), 161-173. Springer
Epma journal, 9(2), 161-173. Springer International Publishing AG
The EPMA Journal

Background It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods This analysis included 499 patients from the Trial of Inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4497533df759f15731aa05ebaf62ff0
https://hdl.handle.net/11370/44288a60-caf4-47b8-9f2e-501cc8b9685a

Prognostic Utility of a Modified HEART Score in Chest Pain Patients in the Emergency Department

Autor: James McCord, Rafael Cabrera, Bertil Lindahl, Evangelos Giannitsis, Kaleigh Evans, Richard Nowak, Tiberio Frisoli, Richard Body, Michael Christ, Christopher R. deFilippi, Robert H. Christenson, Gordon Jacobsen, Aitor Alquezar, Mauro Panteghini, Dina Melki, Mario Plebani, Franck Verschuren, John French, Garnet Bendig, Silvia Weiser, Christian Mueller, Raphael Twerenbold, Hugo A. Katus, Steffen Popp, Jorge Ordóñez-Llanos, Miquel Santalo-Bel, Daniel Horner, Alberto Dolci, Tomas Jernberg, Martina Zaninotto, Alessandro Manara, Carina Dinkel, Sylvie Menassanch-Volker, Jochen Jarausch, Christian Zaugg

Publikováno v: Circulation-Cardiovascular Quality and Outcomes
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Circulation. Cardiovascular Quality and Outcomes, Vol. 10, no. 2, p. e003101 [1-8] (2017)

Background— The TRAPID-AMI trial study (High-Sensitivity Troponin-T Assay for Rapid Rule-Out of Acute Myocardial Infarction) evaluated high-sensitivity cardiac troponin-T (hs-cTnT) in a 1-hour acute myocardial infarction (AMI) exclusion algorithm.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4139e0e111319f03818ad0a61c96769f
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6684

The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers

Autor: Michelle Zaharik, Christian Zaugg, Kirsten Jakobsen, Fred S. Apple, David A. Morrow, John J. Blackwood, David Hickey

Publikováno v: Clinical Chemistry. 58:31-38

Cardiac troponins I (cTnI)8 and T (cTnT) have been internationally recognized as the standard biomarkers for the detection of myocardial injury, the diagnosis of myocardial infarction (MI), and risk stratification of patients presenting with symptoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff24344a5929c291273830c70855864
https://doi.org/10.1373/clinchem.2011.165860

Troponin Testing for Detection of Acute Myocardial Infarction in Skeletal Muscle Disease Patients

Autor: André Ziegler, Sylvie Menassanch-Volker, Christian Zaugg

Publikováno v: Journal of the American College of Cardiology. 62:941-943

In a recent letter to the editor of the Journal [(1)][1], Rittoo describes what he calls a “fundamental error” in the guidance documents on the diagnosis of acute myocardial infarction (AMI), namely, in the universal definition of AMI [(2)][2] an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ca080a3d4b1367c16c4436324395bf
https://doi.org/10.1016/j.jacc.2013.04.074

Losartan but not enalaprilat acutely reduces reperfusion ventricular tachyarrhythmias in hypertrophied rat hearts after low-flow ischaemia

Autor: Christian Zaugg, Konstantin Beier, Peter Buser, Silvia Butz, Sergey Driamov, Andrea Remondino, Mohamed Bellahcene, André Ziegler

Publikováno v: Journal of Pharmacy and Pharmacology. 56:521-528

Based on clinical and experimental studies, angiotensin II receptor blockers and angiotensin converting enzyme inhibitors have been proposed to exert acute anti-arrhythmic effects in heart failure patients. Therefore, the goal of this study was to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7de77646f19e120678fe46e3d4837bc
https://doi.org/10.1211/0022357023178