Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christian Wuchter"'
Publikováno v:
International Journal of Cancer. 119:1291-1297
Survivin, a member of the inhibitor of apoptosis protein family, is expressed in most human cancers, but undetectable in normal differentiated adult tissue in vivo. Because of this cancer-related expression, survivin is a promising target for cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724b7b3f381f461294aaa39c0218cdc6
https://doi.org/10.1002/ijc.21995
https://doi.org/10.1002/ijc.21995
Autor:
Doreen Oltersdorf, Ursula Creutzig, Ingo Tamm, Wolf-Dieter Ludwig, Stephan Richter, Frank Scholz, Christian Wuchter, Leonid Karawajew, Jochen Harbott
Publikováno v:
Clinical Cancer Research. 10:3737-3744
Purpose: Apoptosis-related proteins are important molecules for predicting chemotherapy response and prognosis in adult acute myeloid leukemia (AML). However, data on the expression and prognostic impact of these molecules in childhood AML are rare.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a006b399d32ac5b69c12b5a3564a8c3b
https://doi.org/10.1158/1078-0432.ccr-03-0642
https://doi.org/10.1158/1078-0432.ccr-03-0642
Autor:
Richard Ratei, Susanne Schnittger, Wolfgang Hiddemann, Claudia Schoch, Alexander Kohlmann, Wolfgang Kern, Wolf-Dieter Ludwig, Susanne Mergenthaler, Christian Wuchter, Torsten Haferlach
Publikováno v:
Cytometry. :29-36
Background Flow cytometry (FC) is a standard method for diagnosing and subclassifying acute myeloid (AML) and acute lymphoblastic (ALL) leukemias and allows the analysis of cell surface and intracellular proteins. In the future, diagnostic procedures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebd487e8027c40faad0a78f4f2760e6
https://doi.org/10.1002/cyto.b.10025
https://doi.org/10.1002/cyto.b.10025
Autor:
S. Pils, Gritta Janka-Schaub, Martin Zimmermann, Susanne Viehmann, Martin Stanulla, Jochen Harbott, Christian Wuchter, Martin Schrappe, Andrea Teigler-Schlegel, Wolf-Dieter Ludwig, Arndt Borkhardt
Publikováno v:
Leukemia. 16:1685-1690
We used karyotyping, fluorescence in situ hybridization (FISH), Southern blotting, and RT-PCR in order to analyze prospectively 77 infants (less than 1 year of age) with acute lymphoblastic leukemia for the occurrence of 11q23/MLL rearrangements and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc646e56cf59d4ccbb31ca90803706b0
https://doi.org/10.1038/sj.leu.2402595
https://doi.org/10.1038/sj.leu.2402595
Autor:
Wolf-Dieter Ludwig, V. Ruppert, Leonid Karawajew, Martin Schrappe, Annett Kösser, Bernd Dörken, Christian Wuchter
Publikováno v:
Blood. 96:297-306
In normal T-cell development, IL-7 plays a nonredundant role as an antiapoptic factor by regulating Bcl-2 expression in pro-T cells. In the current study, we addressed the roles of IL-7 and related cytokines as apoptosis-modulating factors in precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7d509f16a5e0d3982316db39d69acb
https://doi.org/10.1182/blood.v96.1.297
https://doi.org/10.1182/blood.v96.1.297
Autor:
Leonid Karawajew, Bernd Dörken, V. Ruppert, Jochen Harbott, Martin Schrappe, Wolf-Dieter Ludwig, Christian Wuchter, Richard Ratei
Publikováno v:
British Journal of Haematology. 110:154-160
CD95 (Fas/APO-1) expression and function and Bcl-2 expression, as well as spontaneous apoptosis in vitro, have been shown to be predictive markers for the in vivo response to chemotherapy in acute myeloid leukaemia (AML). To determine the clinical si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e362fdad9bedf4472e400afa5334873
https://doi.org/10.1046/j.1365-2141.2000.02147.x
https://doi.org/10.1046/j.1365-2141.2000.02147.x
Autor:
V. Ruppert, Claudia Schoch, Torsten Haferlach, Wolf-Dieter Ludwig, Leonid Karawajew, Th. Büchner, Richard Ratei, Bernd Dörken, Christian Wuchter
Publikováno v:
Leukemia. 13:1943-1953
Resistance to chemotherapy-induced apoptosis and a multidrug-resistance (MDR) phenotype, mainly mediated by P-glycoprotein (P-gp), contribute to chemotherapy failure in hematologic malignancies. To study apoptosis-regulating factors in acute myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24754aa71a7b926cd8021af36e0a7690
https://doi.org/10.1038/sj.leu.2401605
https://doi.org/10.1038/sj.leu.2401605
Autor:
H.-J. Gruss, Hans G. Drexler, Bernd Dörken, Wolf-Dieter Ludwig, V. Ruppert, Leonid Karawajew, Christian Wuchter
Publikováno v:
Leukemia. 11:1245-1252
CD95 (Fas/APO-1) is a cell surface receptor able to trigger apoptosis in a variety of cell types. The expression and function of the CD95 antigen on leukemic blasts from 42 patients with B lineage and 53 patients with T lineage acute lymphoblastic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa9d2546d364b617db5cec910929f45
https://doi.org/10.1038/sj.leu.2400746
https://doi.org/10.1038/sj.leu.2400746
Autor:
Frank Scholz, Torsten Haferlach, Doreen Oltersdorf, Leonid Karawajew, Wolf-Dieter Ludwig, Claudia Schoch, Karin Schmelz, Stephan Richter, Christian Wuchter, Ingo Tamm
Publikováno v:
The hematology journal : the official journal of the European Haematology Association. 5(6)
Antiapoptotic proteins like the inhibitor of apoptosis proteins (IAPs) are molecular markers potentially useful for the characterization of acute myeloid leukemia (AML). We screened 92 adults with de novo AML for the protein expression of various IAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5facd67f3c19c19fa2aba8bfb80be3f
https://pubmed.ncbi.nlm.nih.gov/15570290
https://pubmed.ncbi.nlm.nih.gov/15570290
Autor:
Christian, Wuchter, Stephan, Richter, Doreen, Oltersdorf, Leonid, Karawajew, Wolf-Dieter, Ludwig, Ingo, Tamm
Publikováno v:
Haematologica. 89(3)
Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9350925cbc04aa1eeb66d42470b08aa2
https://pubmed.ncbi.nlm.nih.gov/15020280
https://pubmed.ncbi.nlm.nih.gov/15020280