Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christian Weikert"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45351 (2012)
A canalized genotype is robust to environmental or genetic perturbations. Canalization is expected to result from stabilizing selection on a well-adapted phenotype. Decanalization, the loss of robustness, might follow periods of directional selection
Externí odkaz:
https://doaj.org/article/fb3d43dd42734e69ae29e43fb71c434f
Autor:
Christian Weikert, Andreas Wagner
Publikováno v:
The Open Evolution Journal
Covarying phenotypic traits can limit natural selection's ability to modify these traits. Most evolutionary stud- ies on trait covariation use the comparative method to study complex traits of multicellular organisms. Simpler traits have the advantag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a98a838711c25ae3dc9dc193e17a4e
Publikováno v:
Journal of Evolutionary Biology. 24:1135-1153
Most laboratory evolution studies that characterize evolutionary adaptation genomically focus on genetically simple traits that can be altered by one or few mutations. Such traits are important, but they are few compared with complex, polygenic trait
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc632b07cbf47aeff489f1e54b7d6354
https://doi.org/10.1111/j.1420-9101.2011.02249.x
https://doi.org/10.1111/j.1420-9101.2011.02249.x
Autor:
Jukka Takala, Hendrik Bracht, Luzius B. Hiltebrand, Mario Beck, Stephan M. Jakob, Francesca Porta, Sebastian Brandt, Christian Weikert
Publikováno v:
Porta, Francesca; Bracht, Hendrik; Weikert, Christian; Beck, Mario; Takala, Jukka; Brandt, Sebastian; Hiltebrand, Luzius B; Jakob, Stephan M (2009). Effects of endotoxin and catecholamines on hepatic mitochondrial respiration. Inflammation, 32(5), pp. 315-21. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s10753-009-9138-y
Catecholamines are frequently used in sepsis, but their interaction with mitochondrial function is controversial. We incubated isolated native and endotoxin-exposed swine liver mitochondria with either dopamine, dobutamine, noradrenaline or placebo f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773ecac71f54e5e38782bb21250b022a
https://doi.org/10.1007/s10753-009-9138-y
https://doi.org/10.1007/s10753-009-9138-y
Autor:
Jean-François Dufour, Nadia Corazza, Adrian Keogh, Jan A. Plock, Thomas Brunner, Christian Weikert, Erick Ayuni, Deborah Stroka, Dominique Erni, Sonja Bisch-Knaden, Daniel Candinas, Steffen Frese, Stephan M. Jakob
Publikováno v:
Journal of Hepatology. 47:538-545
Background/Aims:We investigated the molecular response of a non-ischemic hypoxic stress in the liver, in particular, to distinguish its hepatoprotective potential.Methods:The livers of mice were subjected to non-ischemic hypoxia by clamping the hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42324233efd3af35cf40a6b53a153fd6
https://doi.org/10.1016/j.jhep.2007.04.016
https://doi.org/10.1016/j.jhep.2007.04.016
Autor:
Christian Weikert, Jukka Takala, Stephan Krähenbühl, Stephan M. Jakob, Priska Kaufmann, Francesca Porta
Publikováno v:
Journal of Endotoxin Research. 12:358-366
INTRODUCTION: Mitochondrial respiration is impaired during endotoxemia. While catecholamines are frequently used in sepsis, their effects on mitochondrial function are controversial. We assessed effects of dobutamine and dopamine endotoxin on isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b0e59c9321bf7c7801c3c571872c8a
https://doi.org/10.1179/096805106x153952
https://doi.org/10.1179/096805106x153952
Autor:
Lionel Wightman, Christian Weikert, Daniel A. Dätwyler, Ernst Wagner, Hans M. Eppenberger, Josef P. Magyar
Publikováno v:
Cells Tissues Organs. 175:61-71
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities. To get a better understanding of the cardiac cell cycle and its regulation, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5709fca78e667939d0a3cf12565ab5ae
https://doi.org/10.1159/000073750
https://doi.org/10.1159/000073750
Autor:
M. Stöckle, Thomas Otto, M. Hack, Christian Doehn, Kurt Miller, H. Huland, Andre Nagy, Susanne Krege, Christian Weikert, John Groffen, Stefan Siemer, Daniel A. Dätwyler, Margitta Retz, Nora Heisterkamp, Herbert Rübben, Vesa Kaartinen, Ignacio Gonzalez-Gomez, J. Noldus, Lionel Wightman, D. Jocham, D. Rohde, Karen Leung, Josef P. Magyar, J. Suhr, Hans M. Eppenberger, Jan Lehmann, Ernst Wagner
Publikováno v:
Oncology Research and Treatment. 26:III-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2083b50032354b5554d89e69c1af0a01
https://doi.org/10.1159/000073801
https://doi.org/10.1159/000073801
Autor:
Lionel Wightman, Christian Weikert, Margitta Retz, M. Hack, Jan Lehmann, J. Suhr, Hans M. Eppenberger, Thomas Otto, Vesa Kaartinen, Nora Heisterkamp, Ernst Wagner, Stefan Siemer, Josef P. Magyar, Christian Doehn, M. Stöckle, Karen Leung, D. Jocham, D. Rohde, Ignacio Gonzalez-Gomez, J. Noldus, Herbert Rübben, Daniel A. Dätwyler, Susanne Krege, H. Huland, Andre Nagy, John Groffen, Kurt Miller
Publikováno v:
Oncology Research and Treatment. 26:1-57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ef0ec5d21d287e2267ed9f85005ca9
https://doi.org/10.1159/000073802
https://doi.org/10.1159/000073802
Autor:
Kurt Miller, Christian Doehn, Thomas Otto, Vesa Kaartinen, Hans M. Eppenberger, Stefan Siemer, Karen Leung, M. Stöckle, Ernst Wagner, Herbert Rübben, Christian Weikert, J. Suhr, Ignacio Gonzalez-Gomez, H. Huland, Andre Nagy, J. Noldus, Lionel Wightman, Daniel A. Dätwyler, Margitta Retz, Nora Heisterkamp, Jan Lehmann, M. Hack, D. Jocham, John Groffen, Josef P. Magyar, D. Rohde, Susanne Krege
Publikováno v:
Oncology Research and Treatment. 26:236-247
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e528b18a9c8d9b5c10ce19b662cf3ea7
https://doi.org/10.1159/000073806
https://doi.org/10.1159/000073806