Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Christian W. Siebel"'
Autor:
Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, Sabrina Manni, Alessandro Casellato, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle, Odile Filhol, Brigitte Boldyreff, Christian W. Siebel, Antonella Viola, Giorgio Valle, Federica Mainoldi, Stefano Casola, Valeria Cancila, Alessandro Gulino, Claudio Tripodo, Marco Pizzi, Angelo Paolo Dei Tos, Livio Trentin, Gianpietro Semenzato, Francesco Piazza
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first B-cell specific knockout (KO) mouse model of the β regulatory subunit of CK2. CK2βK
Externí odkaz:
https://doaj.org/article/42f0f970a71d4dd7a8b8d6085144b412
Autor:
Nobukatsu Horita, Theresa M. Keeley, Elise S. Hibdon, Elizabeth Delgado, Daniel Lafkas, Christian W. Siebel, Linda C. Samuelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 275-287 (2022)
Background & Aims: Notch pathway signaling maintains gastric epithelial cell homeostasis by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 and NOTCH2 as the key Notch receptors controlling gastric stem cell fu
Externí odkaz:
https://doaj.org/article/c9c7c90acdba43d3b35b4515ca88e447
Autor:
Daniela Gómez Atria, Brian T. Gaudette, Jennifer Londregan, Samantha Kelly, Eric Perkey, Anneka Allman, Bhaskar Srivastava, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Russell J.H. Ryan, Tanner F. Robertson, Janis K. Burkhardt, Warren S. Pear, David Allman, Ivan Maillard
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting the homeostatic proliferation of mature lymphocytes. The molecular mechanisms underlying these responses and their functional conseque
Externí odkaz:
https://doaj.org/article/aa88b4759e6e46808e2bc89a9767c5db
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell
Externí odkaz:
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/515147b47c8045f7a83bb33af1989d17
Autor:
Valeria Yartseva, Leonard D. Goldstein, Julia Rodman, Lance Kates, Mark Z. Chen, Ying-Jiun J. Chen, Oded Foreman, Christian W. Siebel, Zora Modrusan, Andrew S. Peterson, Ana Jovičić
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1491-1503.e6 (2020)
Summary: How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustainable tissue regeneration is not well understood. A major roadblock to understanding satellite cell fate decisions has been the difficulty of
Externí odkaz:
https://doaj.org/article/369f10c9eb574d9880366d27d4b09e96
Autor:
Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therap
Externí odkaz:
https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f
Autor:
Weihuan Wang, Shuiliang Yu, Jay Myers, Yiwei Wang, William W. Xin, Marwah Albakri, Alison W. Xin, Ming Li, Alex Y. Huang, Wei Xin, Christian W. Siebel, Hillard M. Lazarus, Lan Zhou
Publikováno v:
Haematologica, Vol 102, Iss 10 (2017)
Despite use of newer approaches, some patients being considered for autologous hematopoietic cell transplantation (HCT) may only mobilize limited numbers of hematopoietic progenitor cells (HPCs) into blood, precluding use of the procedure, or being p
Externí odkaz:
https://doaj.org/article/da4e8dbab98447239b48053c4b54e9b2
Autor:
Hua Tian, Brian Biehs, Cecilia Chiu, Christian W. Siebel, Yan Wu, Mike Costa, Frederic J. de Sauvage, Ophir D. Klein
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 33-42 (2015)
Proper organ homeostasis requires tight control of adult stem cells and differentiation through the integration of multiple inputs. In the mouse small intestine, Notch and Wnt signaling are required both for stem cell maintenance and for a proper bal
Externí odkaz:
https://doaj.org/article/ae315e37a59046079e29477b41c2bcdc
Autor:
Ryan A. Wilcox, Ivan Maillard, Christian W. Siebel, John Reneau, Luis Taxa, Carlos Barrionuevo, Jaime Montes, Sandro Casavilca-Zambrano, Kedar Inamdar, Nathanael G. Bailey, Noah Brown, Avery Polk, Ashley Wolfe, Maria Sverdlov, Peter Gann, Carlos Murga-Zamalloa, Nermin Kady, Suhaib Abdelrahman, Chenguang Wang, Xin Gao
Peripheral T-cell lymphomas (PTCL) are agressive lymphomas that develop from mature T cells. The most common PTCLs are genetically, molecularly, and clinically diverse and are generally associated with dismal outcomes. While Notch signaling plays a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ff2b04d1381c3bb2600985dd7cc890
https://doi.org/10.1158/0008-5472.c.6514179
https://doi.org/10.1158/0008-5472.c.6514179