Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christian W Johnson"'
RAS GTPases are proto-oncoproteins that regulate cell growth, proliferation, and differentiation in response to extracellular signals. The signaling functions of RAS, and other small GTPases, are dependent on their ability to cycle between GDP-bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e2501c6889a8d92cc76711aec9673f6
https://doi.org/10.1101/2023.05.29.542740
https://doi.org/10.1101/2023.05.29.542740
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Proteomics data from human cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426b866d556530901ce4ab6f469c7a7
https://doi.org/10.1158/2159-8290.22532587
https://doi.org/10.1158/2159-8290.22532587
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Supplementary Figures S1-S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea23cd43399e8b35ccc18f1cea0e40ed
https://doi.org/10.1158/2159-8290.22532605
https://doi.org/10.1158/2159-8290.22532605
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Data collection and refinement statistics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8366377fb78585b44b56e2021cd08
https://doi.org/10.1158/2159-8290.22532602
https://doi.org/10.1158/2159-8290.22532602
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 423-427 (2016)
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases (Tyrosine phosphorylation of RAS by ABL allosterically enhances effe
Externí odkaz:
https://doaj.org/article/e1f4c5fa290c4bfebc66c15af6809fb9
Autor:
Moon Hee Yang, Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Timothy J. Waybright, Jonathan A. Nowak, Andrew G. Stephen, Dhirendra K. Simanshu, Kevin M. Haigis
Ras proteins are GTPases that regulate a wide range of cellular processes. The activity of Ras is dependent on its nucleotide-binding status, which is modulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34f4256b91986c6fbf6653a67d7cb0aa
https://doi.org/10.1101/2022.09.20.508702
https://doi.org/10.1101/2022.09.20.508702
Autor:
KleinJan F, Gasmi-Seabrook Gmc, Kijun Song, Lakhani J, Ezekiel A. Geffken, Christian W. Johnson, Christopher B. Marshall, Teklab Gebregiworgis, Joao A. Paulo, Olesja Popow, Hyuk-Soo Seo, Kevin M. Haigis, Elizabeth M. Terrell, Deborah K. Morrison, Mitsuhiko Ikura, Carla Mattos, Andrew Bo Liu, Sirano Dhe-Paganon
SUMMARYA unifying feature of the RAS superfamily is a functionally conserved GTPase cycle that proteins use to transition between active and inactive states. Here, we demonstrate that active site autophosphorylation of some small GTPases is an intrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21a5e25ed3359cf636e46a0147800e9
https://doi.org/10.1101/2021.06.23.449327
https://doi.org/10.1101/2021.06.23.449327
Autor:
Christian W. Johnson, Hyuk-Soo Seo, Elizabeth M. Terrell, Moon-Hee Yang, Fenneke KleinJan, Teklab Gebregiworgis, Genevieve M.C. Gasmi-Seabrook, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Puspalata Bashyal, Olesja Popow, Joao A. Paulo, Andrea Liu, Carla Mattos, Christopher B. Marshall, Mitsuhiko Ikura, Deborah K. Morrison, Sirano Dhe-Paganon, Kevin M. Haigis
Publikováno v:
Mol Cell
A unifying feature of the RAS superfamily is a conserved GTPase cycle by which these proteins transition between active and inactive states. We demonstrate that autophosphorylation of some GTPases is an intrinsic regulatory mechanism that reduces nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7484f8740b33d67a4e92ca475419fc4
https://doi.org/10.1016/j.molcel.2022.02.011
https://doi.org/10.1016/j.molcel.2022.02.011
Autor:
Kevin M. Haigis, Elizabeth M. Terrell, Deborah K. Morrison, Christin E. Burd, Christian W. Johnson
Publikováno v:
Cancer Research. 81:84-84
The Kirsten rat sarcoma (KRAS) proto-oncogene regulates signaling pathways that control proliferation (e.g. MAPK pathway), metabolism and survival (e.g. AKT pathway), and apoptosis (e.g. Hippo pathway). Mutations in KRAS are found in 40% of colorecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4edbcc1a1d6c31695a4eb16883c24e8c
https://doi.org/10.1158/1538-7445.am2021-84
https://doi.org/10.1158/1538-7445.am2021-84
Autor:
Christian W. Johnson, Pedro A. Perez-Mancera, Steven P. Gygi, Joshua Cook, Benjamin S. Braun, Jessica J. Gierut, Samantha Dale Strasser, Douglas K. Brubaker, Jonathan A. Nowak, Brian A. Joughin, Rebecca A. Destefanis, Kenneth D. Westover, John R. Engen, Lana Bogdanova, Kevin M. Haigis, Carolina Morales, Emily J. Poulin, Jia Lu, Yi Jang Lin, Phaedra C. Ghazi, Asim K. Bera, Joao A. Paulo, Yina Li, Thomas E. Wales, Wei Yan, Sudershan R. Gondi, Roxana E. Iacob, Tannie Q. Huang, Douglas A. Lauffenburger
Publikováno v:
Cancer Discov
CANCER DISCOVERY
PMC
CANCER DISCOVERY
PMC
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f87a5e50f6b926f0042b2b594d2960
https://europepmc.org/articles/PMC6548671/
https://europepmc.org/articles/PMC6548671/