Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Christian W, Mandl"'
Autor:
Roland Tschismarov, Raphaël M. Zellweger, Min Jie Koh, Yan Shan Leong, Jenny G. Low, Eng Eong Ooi, Christian W. Mandl, Katrin Ramsauer, Ruklanthi de Alwis
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Chikungunya is a mosquito-borne disease that causes periodic but explosive epidemics of acute disease throughout the tropical world. Vaccine development against chikungunya virus (CHIKV) has been hampered by an inability to conduct efficacy trials du
Externí odkaz:
https://doaj.org/article/af56162da81644c2bd6b091d01c0e266
Autor:
Marco Künzli, Stephen D. O’Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan, Andrew G. Soerens, Clare F. Quarnstrom, Sathi Wijeyesinghe, Yanqi Ye, Justine McPartlan, Jason S. Mitchell, Christian W. Mandl, Richard Vile, Marc K. Jenkins, Rafi Ahmed, Vaiva Vezys, Jasdave Chahal, David Masopust
Respiratory tract resident memory T cells (Trm), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes respiratory Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959e5f9e405bb7978a3afd9fcfa18887
https://doi.org/10.1101/2022.06.02.494574
https://doi.org/10.1101/2022.06.02.494574
Autor:
Terika Spencer, Peter W. Mason, Angelica Medina-Selby, Sumana Chandramouli, Ethan C. Settembre, Christian W. Mandl, Doris Coit, Luis Brito, Gillis R. Otten, Mary Schaefer, Philip R. Dormitzer, Pu Zhang
Publikováno v:
Vaccine. 31:3872-3878
Parvovirus B19 is the causative agent of fifth disease in children, aplastic crisis in those with blood dyscrasias, and hydrops fetalis. Previous parvovirus B19 virus-like-particle (VLP) vaccine candidates were produced by co-infection of insect cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a833448b3b2c53819e09b43d248dcaa
https://doi.org/10.1016/j.vaccine.2013.06.062
https://doi.org/10.1016/j.vaccine.2013.06.062
Publikováno v:
Journal of General Virology. 93:504-515
Mature protein C of tick-borne encephalitis virus (TBEV) is cleaved from the polyprotein precursor by the viral NS2B/3 protease (NS2B/3pro). We showed previously that replacement of the NS2B/3pro cleavage site at the C terminus of protein C by the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a6729d32ecad59d666eec7fd24e1bd
https://doi.org/10.1099/vir.0.038398-0
https://doi.org/10.1099/vir.0.038398-0
Publikováno v:
Nucleic Acids Research
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that play a pivotal role in the regulation of posttranscriptional gene expression in a wide range of eukaryotic organisms. Although DNA viruses have been shown to encode miRNAs and exploit the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c4208353405ab22e7da2c61b472aec
http://europepmc.org/articles/PMC3001059
http://europepmc.org/articles/PMC3001059
Autor:
Regina M. Kofler, Christian W. Mandl, Christian Taucher, Eszter Nagy, Beate Schittl, Petra Schlick, Andreas Meinke
Publikováno v:
Vaccine. 28:5903-5909
Protein C deletion mutants of West Nile virus (WNV) were evaluated for their potential use as live virus vaccine candidates in vivo. Double and triple mutants carrying small deletions and second-site point mutations, as well as mutants with large del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74bb563e8d7014832dfabf1fdd4747b
https://doi.org/10.1016/j.vaccine.2010.06.045
https://doi.org/10.1016/j.vaccine.2010.06.045
Publikováno v:
Journal of Virology. 84:599-611
Intermolecular recombination between the genomes of closely related RNA viruses can result in the emergence of novel strains with altered pathogenic potential and antigenicity. Although recombination between flavivirus genomes has never been demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20126a182e58dc9b267fcef588939a62
https://doi.org/10.1128/jvi.01063-09
https://doi.org/10.1128/jvi.01063-09
Publikováno v:
Journal of Virology. 83:11201-11210
The translation of flaviviral RNA genomes yields a single polyprotein that is processed into the mature proteins by viral and host cell proteases. Mature capsid protein C is freed from the polyprotein by the viral NS2B/3 protease, cleaving in the C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1536548240679a213e673efefc7d7a67
https://doi.org/10.1128/jvi.01025-09
https://doi.org/10.1128/jvi.01025-09
Publikováno v:
Journal of Virology. 82:8272-8282
The infectivity of flavivirus particles depends on a maturation process that is triggered by the proteolytic cleavage of the precursor of the M protein (prM). This activation cleavage is naturally performed by ubiquitous cellular proteases of the fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab8a7e2b760d674326a82bdce4a0e8c
https://doi.org/10.1128/jvi.00587-08
https://doi.org/10.1128/jvi.00587-08
Autor:
Verena M. Hoenninger, Christian W. Mandl, Regina M. Kofler, Klaus K. Orlinger, Franz X. Heinz
Publikováno v:
Journal of Virology. 81:12619-12629
Flaviviruses have a positive-stranded RNA genome, which simultaneously serves as an mRNA for translation of the viral proteins. All of the structural and nonstructural proteins are translated from a cap-dependent cistron as a single polyprotein precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d37406c3414d4586eafa6b25055ab98
https://doi.org/10.1128/jvi.01017-07
https://doi.org/10.1128/jvi.01017-07