Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christian Vaccarin"'
Autor:
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expressi
Externí odkaz:
https://doaj.org/article/ad4f974295474f0392325fbd07ff6ab8
Autor:
Christian Vaccarin, Ana Katrina Mapanao, Luisa M. Deberle, Anna E. Becker, Francesca Borgna, Giovanni Marzaro, Roger Schibli, Cristina Müller
Publikováno v:
Cancers, Vol 16, Iss 7, p 1262 (2024)
Transthyretin binders have previously been used to improve the pharmacokinetic properties of small-molecule drug conjugates and could, thus, be utilized for radiopharmaceuticals as an alternative to the widely explored “albumin binder concept”. I
Externí odkaz:
https://doaj.org/article/82b9b6b5f2b14d19b577b25b9afd33e6
Autor:
Sarah D. Busslinger, Anna E. Becker, Christian Vaccarin, Luisa M. Deberle, Marie-Luise Renz, Viola Groehn, Roger Schibli, Cristina Müller
Publikováno v:
Cancers, Vol 15, Iss 17, p 4259 (2023)
Introducing an albumin-binding entity into otherwise short-lived radiopharmaceuticals can be an effective means to improve their pharmacokinetic properties due to enhanced blood residence time. In the current study, DOTA-derivatized albumin binders b
Externí odkaz:
https://doaj.org/article/b7c86f49b5e34d3d965997da2d4edc40
Autor:
Chiara Tupini, Adriana Chilin, Alice Rossi, Ida De Fino, Alessandra Bragonzi, Elisabetta D’Aversa, Lucia Carmela Cosenza, Christian Vaccarin, Gianni Sacchetti, Monica Borgatti, Anna Tamanini, Maria Cristina Dechecchi, Francesca Sanvito, Roberto Gambari, Giulio Cabrini, Ilaria Lampronti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14483 (2022)
A series of new-generation TMA (4,6,4′-trimethyl angelicin) analogues was projected and synthetized in order to ameliorate anti-inflammatory activity, with reduced or absent toxicity. Since the NF-κB transcription factor (TF) plays a critical role
Externí odkaz:
https://doaj.org/article/44a522bed2fa4ba4a4fa5511e2829d0f
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
Autor:
Christian Vaccarin, Daniela Gabbia, Erica Franceschinis, Sara De Martin, Marco Roverso, Sara Bogialli, Gianni Sacchetti, Chiara Tupini, Ilaria Lampronti, Roberto Gambari, Giulio Cabrini, Maria Cristina Dechecchi, Anna Tamanini, Giovanni Marzaro, Adriana Chilin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11528 (2022)
A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising agent for the treatment of cystic fibrosis. To prevent photoreactions with DNA, hindered sub
Externí odkaz:
https://doaj.org/article/ac4097f0c602425aa4b1f0e52423b399
Autor:
Erica Franceschinis, Marco Roverso, Daniela Gabbia, Sara De Martin, Matteo Brusegan, Christian Vaccarin, Sara Bogialli, Adriana Chilin
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1806 (2022)
4,6,4′-trimethylangelicin (TMA) is a promising pharmacological option for the treatment of cystic fibrosis (CF) due to its triple-acting behavior toward the function of the CF transmembrane conductance regulator. It is a poorly water-soluble drug,
Externí odkaz:
https://doaj.org/article/c6324eab598142c9ad87a0b77ebfc284
Autor:
Rosa Di Liddo, Marco Verona, Christian Vaccarin, Laura Acquasaliente, Sandra Schrenk, Monica Piccione, Carola Cenzi, Michele De Franco, Matteo Dal Prà, Giovanni Ribaudo, Maria Grazia Ferlin, Maria Teresa Conconi, Adriana Chilin, Valentina Gandin, Giovanni Marzaro
Publikováno v:
Cancers, Vol 14, Iss 15, p 3647 (2022)
The Epidermal Growth Factor Receptor (EGFR) is a transmembrane glycoprotein belonging to the protein kinase superfamily. It is composed of an extracellular domain, a transmembrane anchoring region and a cytoplasmic region endowed with tyrosine kinase
Externí odkaz:
https://doaj.org/article/382ab9732dbf427baffa260d7010d4d1
Autor:
Onofrio Laselva, Giovanni Marzaro, Christian Vaccarin, Ilaria Lampronti, Anna Tamanini, Giuseppe Lippi, Roberto Gambari, Giulio Cabrini, Christine E. Bear, Adriana Chilin, Maria C. Dechecchi
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The psoralen-related compound, 4,6,4′-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del muta
Externí odkaz:
https://doaj.org/article/9e9c443145484db0a001af967a9d8976
Autor:
Marco Roverso, Giovanni Marzaro, Marco Verona, Paolo Caliceti, Francesca Mastrotto, Daniela Gabbia, Valentina Gandin, Stefano Salmaso, Sara Bogialli, Sara De Martin, Adriana Chilin, Michele De Franco, Christian Vaccarin
Publikováno v:
Journal of Controlled Release. 340:318-330
Tyrosine kinase inhibitors (TKIs) represent one of the most advanced class of therapeutics for cancer treatment. Most of them are also cytochrome P450 (CYP) inhibitors and/or substrates thereof. Accordingly, their efficacy and/or toxicity can be affe
Publikováno v:
J Cyst Fibros
Trikafta, the combination of elexacaftor (VX-445), tezacaftor (VX-661) and ivacaftor (VX-770), was approved for therapy of cystic fibrosis (CF) patients with at least one allele of the CFTR mutation F508del. While the corrector function of VX-445 is