Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christian Vaccarin"'
Autor:
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expressi
Externí odkaz:
https://doaj.org/article/ad4f974295474f0392325fbd07ff6ab8
Autor:
Erica Franceschinis, Marco Roverso, Daniela Gabbia, Sara De Martin, Matteo Brusegan, Christian Vaccarin, Sara Bogialli, Adriana Chilin
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1806 (2022)
4,6,4′-trimethylangelicin (TMA) is a promising pharmacological option for the treatment of cystic fibrosis (CF) due to its triple-acting behavior toward the function of the CF transmembrane conductance regulator. It is a poorly water-soluble drug,
Externí odkaz:
https://doaj.org/article/c6324eab598142c9ad87a0b77ebfc284
Autor:
Onofrio Laselva, Giovanni Marzaro, Christian Vaccarin, Ilaria Lampronti, Anna Tamanini, Giuseppe Lippi, Roberto Gambari, Giulio Cabrini, Christine E. Bear, Adriana Chilin, Maria C. Dechecchi
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The psoralen-related compound, 4,6,4′-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del muta
Externí odkaz:
https://doaj.org/article/9e9c443145484db0a001af967a9d8976
Autor:
Marco Roverso, Giovanni Marzaro, Marco Verona, Paolo Caliceti, Francesca Mastrotto, Daniela Gabbia, Valentina Gandin, Stefano Salmaso, Sara Bogialli, Sara De Martin, Adriana Chilin, Michele De Franco, Christian Vaccarin
Publikováno v:
Journal of Controlled Release. 340:318-330
Tyrosine kinase inhibitors (TKIs) represent one of the most advanced class of therapeutics for cancer treatment. Most of them are also cytochrome P450 (CYP) inhibitors and/or substrates thereof. Accordingly, their efficacy and/or toxicity can be affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d2c3811c45879474b08649ca2e262e
https://doi.org/10.1016/j.jconrel.2021.11.006
https://doi.org/10.1016/j.jconrel.2021.11.006
Publikováno v:
J Cyst Fibros
Trikafta, the combination of elexacaftor (VX-445), tezacaftor (VX-661) and ivacaftor (VX-770), was approved for therapy of cystic fibrosis (CF) patients with at least one allele of the CFTR mutation F508del. While the corrector function of VX-445 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147e1acee48ccdc48d1943b192a6efc7
https://doi.org/10.1016/j.jcf.2021.03.011
https://doi.org/10.1016/j.jcf.2021.03.011
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
Autor:
Christian Vaccarin, Daniela Gabbia, Erica Franceschinis, Sara De Martin, Marco Roverso, Sara Bogialli, Gianni Sacchetti, Chiara Tupini, Ilaria Lampronti, Roberto Gambari, Giulio Cabrini, Maria Cristina Dechecchi, Anna Tamanini, Giovanni Marzaro, Adriana Chilin
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11528
A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising agent for the treatment of cystic fibrosis. To prevent photoreactions with DNA, hindered sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59603fee04b1f3b3a95737385282d546
https://pubmed.ncbi.nlm.nih.gov/36232826
https://pubmed.ncbi.nlm.nih.gov/36232826
Autor:
Sonia Nardella, Marco Dalla Tiezza, André Alker, Marianna Tosato, Nóra V. May, Valerio Di Marco, Helmut Mäcke, Paolo Pastore, Christian Vaccarin, Laura Orian, Marco Verona, Abdirisak Ahmed Isse
Publikováno v:
Inorganic Chemistry
The Cu2+ complexes formed by a series of cyclen derivatives bearing sulfur pendant arms, 1,4,7,10-tetrakis[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO4S), 1,4,7-tris[2-(methylsulfanyl)ethyl]-1,4,7,10-tetraazacyclododecane (DO3S), 1,4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139a5761f5bb298a73b2db1943353cf9
http://europepmc.org/articles/PMC8389837
http://europepmc.org/articles/PMC8389837
Autor:
Chiara Tupini, Adriana Chilin, Alice Rossi, Ida De Fino, Alessandra Bragonzi, Elisabetta D’Aversa, Lucia Carmela Cosenza, Christian Vaccarin, Gianni Sacchetti, Monica Borgatti, Anna Tamanini, Maria Cristina Dechecchi, Francesca Sanvito, Roberto Gambari, Giulio Cabrini, Ilaria Lampronti
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14483
A series of new-generation TMA (4,6,4′-trimethyl angelicin) analogues was projected and synthetized in order to ameliorate anti-inflammatory activity, with reduced or absent toxicity. Since the NF-κB transcription factor (TF) plays a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3db973aa8689aa0a74a0e8cb011462
https://hdl.handle.net/11562/1079851
https://hdl.handle.net/11562/1079851
Autor:
Rosa Di Liddo, Marco Verona, Christian Vaccarin, Laura Acquasaliente, Sandra Schrenk, Monica Piccione, Carola Cenzi, Michele De Franco, Matteo Dal Prà, Giovanni Ribaudo, Maria Grazia Ferlin, Maria Teresa Conconi, Adriana Chilin, Valentina Gandin, Giovanni Marzaro
Publikováno v:
Cancers, 14 (15)
Simple Summary The Epidermal Growth Factor Receptor (EGFR) is a receptor protein involved in many types of cancers. EGFR can be inhibited by monoclonal antibodies (protein drugs acting on the extracellular domain of the protein) or by ATP-mimic compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9b330b50e84a06e3ac8870d5bfa410
http://hdl.handle.net/11577/3455167
http://hdl.handle.net/11577/3455167
Autor:
Elisabetta D'Aversa, Gianni Sacchetti, Giovanni Marzaro, Ilaria Lampronti, Christian Vaccarin, Giulio Cabrini, Roberto Gambari, Giorgia Miolo, Maria Cristina Dechecchi, Adriana Chilin
Publikováno v:
European Journal of Medicinal Chemistry. 151:285-293
A series of trimethylangelicin (TMA) derivatives were designed and synthesized to overcome the unwanted effects of TMA, promising agent for treatment of inflammation-related diseases and other pathologies, such as cystic fibrosis. The new generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e0733c8a083ff008ee24d0b26896b8
https://doi.org/10.1016/j.ejmech.2018.03.080
https://doi.org/10.1016/j.ejmech.2018.03.080