Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christian Tränkle"'
Autor:
Sebastian Seufert, Roland Coras, Christian Tränkle, Darius P. Zlotos, Ingmar Blümcke, Lars Tatenhorst, Michael T. Heneka, Eric Hahnen
Publikováno v:
PPAR Research, Vol 2008 (2008)
Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which
Externí odkaz:
https://doaj.org/article/2c61bcf6f78a4fd497f37037228a77f4
Autor:
Matthias Irmen, Janine Holze, Michael Kauk, Marcel Bermudez, Marco De Amici, Clelia Dallanoce, Klaus Mohr, Theresa Bödefeld, Gabriele M. König, Andreas Bock, Eva Marie Pfeil, Carsten Hoffmann, Gerhard Wolber, Carlo Matera, Ulrike Holzgrabe, Evi Kostenis, Ramona Schrage, Christian Tränkle
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Allosteric coupling describes a reciprocal process whereby G-protein-coupled receptors (GPCRs) relay ligand-induced conformational changes from the extracellular binding pocket to the intracellular signaling surface. Therefore, GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b5f203c7b3b178ef34fa4414d35cba
https://doi.org/10.1021/acsptsci.0c00069
https://doi.org/10.1021/acsptsci.0c00069
Autor:
Simon Schramm, Matthias Irmen, Christian Tränkle, Michael Decker, Timo Littmann, Hubert Gerwe, Gerhard Wolber, Luca Agnetta, Marcel Bermudez, Janine Holze
Publikováno v:
ChemMedChem. 14:1349-1358
Recently, investigations of the complex mechanisms of allostery have led to a deeper understanding of G protein-coupled receptor (GPCR) activation and signaling processes. In this context, muscarinic acetylcholine receptors (mAChRs) are highly releva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a2e20d3265aa2902aa274db5a4008b
https://doi.org/10.1002/cmdc.201900283
https://doi.org/10.1002/cmdc.201900283
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 391:1037-1052
Firstly, it was determined whether methanthelinium bromide (MB) binds to human M1-M5 (hM1-hM5) muscarinic acetylcholine receptors in comparison to the classical muscarinic antagonist N-methylscopolamine (NMS). [3H]NMS dissociation binding experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d577b3c1e9f36968bf3363d183b512
https://doi.org/10.1007/s00210-018-1525-1
https://doi.org/10.1007/s00210-018-1525-1
Autor:
Carlo Matera, Andreas Bock, Christoph A. Sotriffer, Brian Chirinda, Regina Messerer, Lisa Flammini, Michael Decker, Matthias Irmen, Marco De Amici, Ulrike Holzgrabe, Christian Tränkle, Elisabetta Barocelli, Sarah Wehle, Clelia Dallanoce
Publikováno v:
MedChemComm. 8:1346-1359
A set of hybrid compounds composed of the fragment of allosteric modulators of the muscarinic receptor, i.e. W84 and naphmethonium, and the well-known AChE inhibitor tacrine on the one hand, and the skeletons of the orthosteric muscarinic agonists, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5e32049e4149b6a64811bb9b4ea2f8
https://doi.org/10.1039/c7md00149e
https://doi.org/10.1039/c7md00149e
Autor:
Janine Holze, Dina Manetti, Christian Tränkle, Klaus Mohr, Elisabetta Teodori, Maria Vittoria Martino, Cristina Bellucci, Maria Novella Romanelli, Giulio Vistoli, Jessica Welzel, Silvia Dei, Angelica Mazzolari, Marta Nesi, Ulrike Bartz, Rosanna Matucci
Publikováno v:
European journal of pharmacology. 883
Although agonists and antagonists of muscarinic receptors have been known for long time, there is renewed interest in compounds (such as allosteric or bitopic ligands, or biased agonists) able to differently and selectively modulate these receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88ca14a4fbf7a1acd767dca1e4963fc
https://pubmed.ncbi.nlm.nih.gov/32534072
https://pubmed.ncbi.nlm.nih.gov/32534072
Autor:
Esther Pohl-Rescigno, Julika Borde, Guido Neidhardt, Elisabeth Mangold, Christian Tränkle, Alfons Meindl, Harald Surowy, Norbert Arnold, Jan Hauke, Christian Sutter, Nana Weber-Lassalle, Kristina Klaschik, Gunter Rappl, Christoph Engel, Stefanie Heilmann-Heimbach, Dieter Niederacher, Sandra Schmidt, Eric Hahnen, Rita K. Schmutzler, Barbara Burwinkel, Barbara Wappenschmidt, Corinna Ernst, Konstantin Weber-Lassalle
Publikováno v:
International journal of cancer. 144(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524572ee8c1d212bfdf0e4fefa7733c1
https://pubmed.ncbi.nlm.nih.gov/30474109
https://pubmed.ncbi.nlm.nih.gov/30474109
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 391(10)
Firstly, it was determined whether methanthelinium bromide (MB) binds to human M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d6e59bcc1da206371aaac05f6700ebb
https://pubmed.ncbi.nlm.nih.gov/29938305
https://pubmed.ncbi.nlm.nih.gov/29938305
Autor:
Regina, Messerer, Clelia, Dallanoce, Carlo, Matera, Sarah, Wehle, Lisa, Flammini, Brian, Chirinda, Andreas, Bock, Matthias, Irmen, Christian, Tränkle, Elisabetta, Barocelli, Michael, Decker, Christoph, Sotriffer, Marco, De Amici, Ulrike, Holzgrabe
Hybrids of allosteric modulators of the muscarinic receptor and the AChE inhibitor tacrine and the orthosteric muscarinic agonists iperoxo and isox were synthesized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0b7484fb2067fae53c3cf3de045f96b
https://europepmc.org/articles/PMC6072511/
https://europepmc.org/articles/PMC6072511/
Autor:
Christoph Enzensperger, Christian Tränkle, Christian Fleck, Robert Otto, Dorothea Appenroth, Jochen Lehmann, Thomas Winckler, Friedemann Gaube, Robert Penzis
Publikováno v:
European Journal of Medicinal Chemistry. 87:63-70
Nine novel β- and γ-carboline derivatives bearing either methyl-, propargyl- or phenethyl-residues at the indole nitrogen were synthesized and tested as potential anti-Alzheimer drugs. Antagonism of recombinantly expressed NMDA receptors, inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e390437c1d94743ea2f57043d5a4ca1b
https://doi.org/10.1016/j.ejmech.2014.09.048
https://doi.org/10.1016/j.ejmech.2014.09.048