Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Christian Stockmann"'
Autor:
Zheng Fan, Mara Karakone, Shunmugam Nagarajan, Nadine Nagy, Wiebke Mildenberger, Ekaterina Petrova, Laura Catharina Hinte, Mitchell Bijnen, Philipp Häne, Eric Nelius, Jing Chen, Irina Ferapontova, Ferdinand von Meyenn, Francesco Trepiccione, Mesut Berber, David Penton Ribas, Anne Eichmann, Maria-Christina Zennaro, Norihiko Takeda, Jens W. Fischer, Ariadni Spyroglou, Martin Reincke, Felix Beuschlein, Johannes Loffing, Melanie Greter, Christian Stockmann
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114395- (2024)
Summary: Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preser
Externí odkaz:
https://doaj.org/article/02b69b219d364673aaf81f6bfedf2bb0
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Autor:
Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, Veronika Matei-Rascu, Rémi Fiancette, Caroline Nordenvall, Ulrik Lindforss, Syed Murtuza Baker, Christian Stockmann, Veronika Sexl, Scott A. Hammond, Simon J. Dovedi, Jenny Mjösberg, Matthew R. Hepworth, Gianluca Carlesso, Menna R. Clatworthy, David R. Withers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mecha
Externí odkaz:
https://doaj.org/article/27d36aa7031e441daba36d10fc106a98
Autor:
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadège Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Obesity and inflammation have been associated to cancer progression. Here, the authors show that high fat and cholesterol diet, in a non-obese context, promotes tumourigenesis through increasing inflammatory monocytes and myeloid-derived pro-angiogen
Externí odkaz:
https://doaj.org/article/9d1b5cbfa4cd4a4690d9acceffb058b5
Autor:
Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Annette Audigé, Khanh Huỳnh, Julian Zacharjasz, Julien Debbache, Yann Kerdiles, Dagmar Gotthardt, Norihiko Takeda, Joachim Fandrey, Lukas Sommer, Veronika Sexl, Christian Stockmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can
Externí odkaz:
https://doaj.org/article/95b70bae74314a89afad5e46b3247257
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate Lymphoid Cells (ILCs) are the innate counterpart of adaptive lymphoid T cells. They are key players in the regulation of tissues homeostasis and early inflammatory host responses. ILCs are divided into three groups, and further subdivided into
Externí odkaz:
https://doaj.org/article/1d46264c29514f438086c052e87d9adf
Autor:
João Paulo Figueiró Longo, Luis Alexandre Muehlmann, Marcelo Calderón, Christian Stockmann, Ricardo Bentes Azevedo
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/0a252474a8ca429c81acec674143e589
Autor:
Hajime Abe, Norihiko Takeda, Takayuki Isagawa, Hiroaki Semba, Satoshi Nishimura, Masaki Suimye Morioka, Yu Nakagama, Tatsuyuki Sato, Katsura Soma, Katsuhiro Koyama, Masaki Wake, Manami Katoh, Masataka Asagiri, Michael L. Neugent, Jung-whan Kim, Christian Stockmann, Tomo Yonezawa, Ryo Inuzuka, Yasushi Hirota, Koji Maemura, Takeshi Yamashita, Kinya Otsu, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardia
Externí odkaz:
https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b9
Autor:
Ewelina Krzywinska, Chahrazade Kantari-Mimoun, Yann Kerdiles, Michal Sobecki, Takayuki Isagawa, Dagmar Gotthardt, Magali Castells, Johannes Haubold, Corinne Millien, Thomas Viel, Bertrand Tavitian, Norihiko Takeda, Joachim Fandrey, Eric Vivier, Veronika Sexl, Christian Stockmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic
Externí odkaz:
https://doaj.org/article/9fad3e202ec447b8825aaed0e43794af
Autor:
Ralph Klose, Ewelina Krzywinska, Magali Castells, Dagmar Gotthardt, Eva Maria Putz, Chahrazade Kantari-Mimoun, Naima Chikdene, Anna-Katharina Meinecke, Katrin Schrödter, Iris Helfrich, Joachim Fandrey, Veronika Sexl, Christian Stockmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent
Externí odkaz:
https://doaj.org/article/26b59077ba8c4ef5af5427b06f0a12dc
Autor:
Johannes Vogel, Cora Sandra Thiel, Svantje Tauber, Christian Stockmann, Max Gassmann, Oliver Ullrich
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 436 (2019)
Immune system deterioration in space represents a major risk, which has to be mitigated for exploration-class missions into the solar system. Altered gravitational forces have been shown to regulate adaptation processes in cells of the immune system,
Externí odkaz:
https://doaj.org/article/bd4caf7514814bf0bc5386e5d74a5a26