Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christian Steinkuhler"'
Autor:
Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni, Stella Gagliardi, Maria Garofalo, Gabriele Antonio Zingale, Irene Pandino, Diego Sbardella, Lina Cipolla, Simone Sabbioneda, Antonella Farsetti, Chiara Ripamonti, Gianluca Fossati, Christian Steinkühler, Carlo Gaetano, Sandra Atlante
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynam
Externí odkaz:
https://doaj.org/article/1aee7acab3d541f682bf1fe58ec3c016
Autor:
Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni, Christian Steinkühler
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract Background In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectories in mice and hum
Externí odkaz:
https://doaj.org/article/0f356416b1154c7383749c0960a74fa8
Autor:
Chiara Ripamonti, Valeria Spadotto, Pietro Pozzi, Andrea Stevenazzi, Barbara Vergani, Mattia Marchini, Giovanni Sandrone, Emanuele Bonetti, Luca Mazzarella, Saverio Minucci, Christian Steinkühler, Gianluca Fossati
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The COVID-19 pandemic has had a devastating impact worldwide and has been a great challenge for the scientific community. Vaccines against SARS-CoV-2 are now efficiently lessening COVID-19 mortality, although finding a cure for this infection is stil
Externí odkaz:
https://doaj.org/article/0c1ff99d0fea4886888c9748e6955d52
Autor:
Samuele Cazzamalli, Eduard Figueras, Lilla Pethő, Adina Borbély, Christian Steinkühler, Dario Neri, Norbert Sewald
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 14726-14731 (2018)
Externí odkaz:
https://doaj.org/article/1dbd508179914e53a63876afc1a200a8
Autor:
Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional
Externí odkaz:
https://doaj.org/article/83d2e7378e224af4803dfe205aa1bd4a
Autor:
Ivan Ranđelović, Sabine Schuster, Bence Kapuvári, Gianluca Fossati, Christian Steinkühler, Gábor Mező, József Tóvári
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4763 (2019)
Among various homing devices, gonadotropin-releasing hormone-III (GnRH-III) peptide represents a suitable targeting moiety for drug delivery systems. The anti-tumor activity of the previously developed GnRH-III-[4Lys(Bu),8Lys(Dau=Aoa)] conjugate and
Externí odkaz:
https://doaj.org/article/e4e2f6ede81f4c35a1b48ece35bfd1d8
Autor:
Eduard Figueras, Ana Martins, Adina Borbély, Vadim Le Joncour, Paola Cordella, Raffaella Perego, Daniela Modena, Paolo Pagani, Simone Esposito, Giulio Auciello, Marcel Frese, Paola Gallinari, Pirjo Laakkonen, Christian Steinkühler, Norbert Sewald
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 220 (2019)
Tumor targeting has emerged as an advantageous approach to improving the efficacy and safety of cytotoxic agents or radiolabeled ligands that do not preferentially accumulate in the tumor tissue. The somatostatin receptors (SSTRs) belong to the G-pro
Externí odkaz:
https://doaj.org/article/04c4cbe3d3224ffab4063a1f948b8f66
Autor:
Adina Borbély, Eduard Figueras, Ana Martins, Simone Esposito, Giulio Auciello, Edith Monteagudo, Annalise Di Marco, Vincenzo Summa, Paola Cordella, Raffaella Perego, Isabell Kemker, Marcel Frese, Paola Gallinari, Christian Steinkühler, Norbert Sewald
Publikováno v:
Pharmaceutics, Vol 11, Iss 4, p 151 (2019)
Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52
Externí odkaz:
https://doaj.org/article/8e55442c453b47dfb515e3a4632fb51a
Autor:
Genesio Di Muro, Rosa Catalano, Donatella Treppiedi, Anna Maria Barbieri, Federica Mangili, Giusy Marra, Sonia Di Bari, Emanuela Esposito, Emma Nozza, Andrea G. Lania, Emanuele Ferrante, Marco Locatelli, Daniela Modena, Christian Steinkuhler, Erika Peverelli, Giovanna Mantovani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3606 (2024)
Somatostatin receptor ligands (SRLs) with high affinity for somatostatin receptors 2 and 5 (SSTR2 and SSTR5) are poorly efficacious in NF-PitNETs, expressing high levels of SSTR3. ITF2984 is a pan-SSTR ligand with high affinity for SSTR3, able to ind
Externí odkaz:
https://doaj.org/article/65798267d72c4d5a8c411f340b90bd74
Autor:
Daniela Modena, Moras Maria Luisa, Giovanni Sandrone, Andrea Stevenazzi, Barbara Vergani, Pooja Dasgupta, Andrea Kliewer, Sebastian Gulde, Mathias Schillmaier, Raul M. Luque, Stefan Schulz, Natalia Pellegata, Christian Steinkuhler
Publikováno v:
Endocrine Abstracts.