Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian Spick"'
Autor:
Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-cytokine fusions targeted against tumor-associated antigens (TAAs) are promising cancer immunotherapy agents, with many such molecules currently undergoing clinical trials. However, due to the limited number of tumor-specific targets
Externí odkaz:
https://doaj.org/article/ee329adfb2144539ad1e235379420104
Autor:
Anja Schrade, Alexander Bujotzek, Christian Spick, Martina Wagner, Johannes Goerl, Xenia Wezler, Guy Georges, Roland E. Kontermann, Ulrich Brinkmann
Publikováno v:
Antibodies, Vol 8, Iss 3, p 45 (2019)
Bispecific antibodies (bsAbs) with avidity-enhanced specificity can be used to address target cells with increased specificity, ideally binding efficiently to cells that express two cognate antigens, yet not to cells that express only one of those. B
Externí odkaz:
https://doaj.org/article/a9c44bbc4a8840b5941f96c57d32a5bc
Autor:
Michael J. E. Marshall, Alexander Knaupp, Christian Spick, Ilker Koese, Maria Maier, Mark S. Cragg, Florian Cymer, Tilman Schlothauer
Publikováno v:
The Journal of Immunology. 210:1837-1848
The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1574a9059fe0899ece0e0eeac38b47c5
https://doi.org/10.4049/jimmunol.2100370
https://doi.org/10.4049/jimmunol.2100370
Autor:
Steffen Lippold, Michaela Hook, Christian Spick, Alexander Knaupp, Kevin Whang, Fabian Ruperti, Lance Cadang, Nisana Andersen, Annette Vogt, Michael Grote, Dietmar Reusch, Markus Haberger, Feng Yang, Tilman Schlothauer
Publikováno v:
Analytical Chemistry. 95:2260-2268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4f53e3f3a5ec666eb586b8553e20c3
https://doi.org/10.1021/acs.analchem.2c03827
https://doi.org/10.1021/acs.analchem.2c03827
Autor:
Xenia Wezler, Roland E. Kontermann, Alexander Bujotzek, Martina Wagner, Guy Georges, Ulrich Brinkmann, Johannes Goerl, Anja Schrade, Christian Spick
Publikováno v:
Antibodies, Vol 8, Iss 3, p 45 (2019)
Antibodies
Volume 8
Issue 3
Antibodies
Volume 8
Issue 3
Bispecific antibodies (bsAbs) with avidity-enhanced specificity can be used to address target cells with increased specificity, ideally binding efficiently to cells that express two cognate antigens, yet not to cells that express only one of those. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395d68c0292ac9c8cee620c0cd614163
https://www.mdpi.com/2073-4468/8/3/45
https://www.mdpi.com/2073-4468/8/3/45
Autor:
Stefan Seeber, Jerome Egli, Antonio Iglesias, Thomas Singer, Alex Odermatt, Tilman Schlothauer, Christian Spick
Publikováno v:
Pharmaceutical Research
Purpose The Göttingen minipig is a relevant non-rodent species for regulatory toxicological studies. Yet, its use with therapeutic antibodies has been limited by the unknown binding properties of human immunoglobulins (huIgG) to porcine Fc gamma rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bf2caeccce250d62c2f6caa2aaec82
https://doi.org/10.1007/s11095-019-2574-y
https://doi.org/10.1007/s11095-019-2574-y
Autor:
Philippe Ringler, Matthias E. Lauer, Peter Kern, Ulrich Brinkmann, Christian Spick, Steffen Dickopf
Publikováno v:
Biological chemistryReferences. 400(3)
A novel bispecific antibody format was applied to generate T cell-engaging antibodies. The TriFab format is a trivalent IgG-shaped entity composed of two Fab arms that bind to antigens on the surface of tumor cells, which are linked via flexible pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8085c91087f607f6ac8a7b16402ecd6f
https://pubmed.ncbi.nlm.nih.gov/30763031
https://pubmed.ncbi.nlm.nih.gov/30763031
Autor:
Ulrike Reiff, Alexander Knaupp, Hubert Hertenberger, Lothar Kling, Andreas Wolfert, Petra Rueger, Christian Spick, Georg Drabner, Jan Olaf Stracke, Hans Koll, Thomas Emrich, Wilma Lau, Tilman Schlothauer, Apollon Papadimitriou
Publikováno v:
mAbs
Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical development. Oxidation of Fc methionines Met252 and Met428 is frequently observed, which leads to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fd155c1a4fa90162b31bf404998258
https://doi.org/10.4161/mabs.29601
https://doi.org/10.4161/mabs.29601
Autor:
Jochen Felix Kepert, Tilman Schlothauer, Christian Spick, Hermann Beck, Brigitte Hienz, Patrick Bulau, Dietmar Reusch, Michaela Hook, Katrin Bomans, Jana Gassner, Philipp Metzger, Adrian Zwick, Markus Haberger, Katharina Diepold, Michael Wiedmann, Michael Molhoj, Constanze Knoblich, Ulla Grauschopf
Publikováno v:
mAbs
Modifications like asparagine deamidation, aspartate isomerization, methionine oxidation, and lysine glycation are typical degradations for recombinant antibodies. For the identification and functional evaluation of antibody critical quality attribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce821cdeb9d7ebff1154620ee09dffa
https://doi.org/10.4161/mabs.27876
https://doi.org/10.4161/mabs.27876
Autor:
Sandra Grau-Richards, Christian Spick, Tilman Schlothauer, Manfred Kubbies, Claudia Ferrara Koller, Sylvia Herter, Ekkehard Mössner, Christian Klein, Pablo Umana, Virginie Steinhart
Publikováno v:
Protein engineering, designselection : PEDS. 29(10)
Recombinant human IgG antibodies (hIgGs) completely devoid of binding to Fcγ receptors (FcγRs) and complement protein C1q, and thus with abolished immune effector functions, are of use for various therapeutic applications in order to reduce FcγR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de9fd4ad363088a805370de6176920d
https://pubmed.ncbi.nlm.nih.gov/27578889
https://pubmed.ncbi.nlm.nih.gov/27578889